The Conversation UK

Scientists in America have developed a nasal spray that can remove proteins in the brain associated with Alzheimer’s disease – at least, in mice. There are two proteins implicated in Alzheimer’s: amyloid and tau. Most of the drugs – included those recently approved by the US Food and Drug Administration (FDA) – focus on removing amyloid. To date, though, there has been little focus on removing tau “tangles”. However, the new nasal spray, developed by researchers at the University of Texas Medical Branch, focuses on this protein.

Nasal spray clears proteins linked to Alzheimer’s – new study

A study reveals that brain inflammation leads to the release of a protein that impairs muscle function, suggesting potential treatments for related muscle fatigue in diseases like Alzheimer’s and long COVID. Infections and neurodegenerative diseases are known to cause brain inflammation. However, patients with brain inflammation often develop muscle...

Hidden Connection Discovered: New Research Links Brain Inflammation to Muscle Fatigue

Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges. Despite advancements in medical research, late-stage HCC patients have a dismal five-year survival rate of less than 20%. The complexity of liver cancer development involves an intricate interplay of genetic and environmental factors. Among these, mitochondrial alterations and mutations in mitochondrial DNA (mtDNA) are increasingly recognized as critical contributors to cancer pathogenesis. These changes not only impair cellular bioenergetics but also influence tumor suppressors and oncogenic proteins, exacerbating the malignancy. Consequently, targeting mitochondrial dysfunction and mtDNA mutations has emerged as a promising therapeutic strategy.

Deciphering the role of mitochondrial DNA targeted therapy in hepatic cell carcinoma

The liver has a remarkable ability to regenerate. This property is crucial for maintaining organ function and recovery after injury or surgery. Scientists from the University of Leipzig Medical Center, the Max Planck Institute for Evolutionary Anthropology, TU Dresden and ETH Zurich have used clinical samples to investigate how cell types in the liver change before and after regeneration. They have created a cell atlas from recent study data and published their research in Nature Communications.

Researchers create a cell atlas of the regenerating liver

Neurologists diagnose cognitive impairment with a clinical exam of memory and thinking skills. To determine whether Alzheimer’s disease is the cause of the cognitive impairment, evidence of the specific brain changes that characterize Alzheimer’s must be obtained, typically via a brain scan or spinal tap. Identifying people whose cognitive symptoms are due to Alzheimer’s disease is critical now that new Alzheimer’s therapies are available that could change the course of the illness.

Accuracy of diagnostic blood tests for Alzheimer’s disease varies

Researchers at the Institute for Systems Biology (ISB) have found significant correlations between age, sex, and BMI, and the frequency of bowel movements. Everybody poops, but not every day. New research from the Institute for Systems Biology (ISB) indicates that the frequency of bowel movements is connected to long-term health.

New Research Indicates That How Often You Poop Could Predict Your Health – Are You in the “Goldilocks Zone”?

Serving tech enthusiasts for over 25 years. Something to look forward to: Cancer has proven to be an extremely elusive target, with tumors developing resistance that allows them to sidestep drugs designed to treat them. However, a group of scientists has now devised a clever new strategy that turns cancer cells suicidal, forcing them to turn against each other.

Scientists trick cancer cells into self-destructing through genetic editing

San Francisco, CA

UCSF and UC Davis researchers identified a new hormone, CCN3, that strengthens bones in breastfeeding women and could treat osteoporosis and enhance fracture healing. Researchers from UCSF and UC Davis have resolved a longstanding mystery about how breastfeeding women maintain strong bones despite losing calcium to milk production. A newly...

Long-Standing Puzzle Solved: Scientists Discover a New Hormone That Can Double Bone Mass

Imagine tiny fists punching their way through your body. For some cancer patients, this may be the reality. Melanoma cells can mechanically tunnel their way through tissue using fleshy membrane protrusions without the need for chemicals that chew up the environment, researchers report June 12 in Developmental Cell. Cells have...

Some melanoma cancer cells may punch their way through the body

Interesting Engineering

This discovery offers a new target for therapeutic development.

Scientists finally discover DNA key to fight deadly pancreatic cancer

shefinds

When it comes to maintaining optimal health, supplements can often be a great addition to your diet. However, it’s important to exercise caution; some supplements may pose significant risks. While supplements are often marketed as natural and beneficial, excessive or improper use can lead to serious health consequences. This is oftentimes especially true when it comes to the health of your liver and kidneys.

6 Unexpected Supplements That May Actually Be Leading To Kidney & Liver Damage, According To Experts: Green Tea Extract & More

Hard palate cancer is a rare oral cancer that forms on the roof of your mouth. While the exact cause may be unclear, some of the most common risk factors include tobacco and alcohol use. This form of cancer often appears as a bump or sore in your mouth that...

What to Know About Hard Palate Cancer

IFLScience

It’s also shaped like a butterfly (if you squint).

This Small Organ Is Very Important, But You Might Not Know Much About It

A recent study in mice finds that a two-drug combination may effectively reverse diabetes. The drugs work by ‘regrowing’ the cells in the pancreas that produce insulin. In just 3 months, these cells increased in number by up to 700%. While much more research is needed, the results...

Could an experimental drug fight diabetes by regenerating insulin-producing cells?

A research team led by University of Liège scientists has published a groundbreaking study on malignant catarrhal fever (MCF). This disease is caused by the alcelaphine gammaherpesvirus 1 (AlHV-1), which infects its natural host, the wildebeest. This study sheds light on the mechanisms by which this virus, which is asymptomatic and latent in the wildebeest, causes an oligoclonal expansion of CD8+ T lymphocytes in cattle, leading to the development of MCF.

New progress in research into malignant catarrhal fever in cattle

A study reveals a new mechanism where proteins released during migraine auras are transported to sensory nerves, triggering migraines, which could lead to innovative treatments. This discovery explains the one-sided nature of migraines and identifies potential new protein targets for therapies. A new study has uncovered a previously unidentified process...

Breakthrough Study Reveals Hidden Mechanism Behind Migraines

A team of researchers at NYU Abu Dhabi, led by Professor Sehamuddin Galadari, has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cell death called ferroptosis in human glioblastoma – the most common and aggressive type of brain tumor – while sparing healthy cells. This new understanding has the potential to inform the development of novel treatments for various hard-to-treat cancers and neurodegenerative diseases.

Tumor Suppressor Protein Triggers Unique Death Pathway in Cancer Cells

UNSW Sydney researchers have made new discoveries of fundamental differences in biological processes between males and females—by interrogating the unique and diverse sex chromosome systems of the platypus and the chicken. The findings, published today in Proceedings of the National Academy of Sciences (PNAS), are a surprise in the...

Platypus and chicken reveal how chromosomes balance between the sexes

German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Glioblastomas are highly aggressive, usually incurable brain tumors. If all therapeutic options are exhausted, patients have an average life expectancy of less than two years. Now researchers from the German Cancer Consortium (DKTK) at the West German Tumor Center Essen have made a surprising discovery: in the vicinity of glioblastomas, they found islands of highly potent immune cells in the neighboring bone marrow of the skull, which play a central role in defending against cancer. The new data may open up prospects for innovative therapies. On the other hand, they cast a shadow over conventional strategies.

Surprising finding in glioblastomas:

Kentucky State

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Northern Kentucky Tribune

Gov. Andy Beshear sent a letter to Anne Milgram, administrator for the U.S. Drug Enforcement Administration (DEA) on Wednesday, expressing his support of the U.S. Department of Health and Human Services’ recommendation that the DEA ease restrictions on marijuana.

Gov. Andy Beshear pens letter to DEA in support of easing federal restrictions on marijuana

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Researchers decipher new molecular mechanisms related to biological tissue regeneration

A study lead by the University of Barcelona opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses...

Researchers decipher new molecular mechanisms related to biological tissue regeneration

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