Caitlin Costello, MD, presents the case of a 60-year-old woman with later relapsed/refractory multiple myeloma and discusses how the treatment landscape has evolved, highlighting remaining unmet needs. Case: A 60-Year-Old Woman with Later Relapsed/Refractory Multiple Myeloma. Clinical Presentation:. A 60-year-old woman who was previously diagnosed 3 years ago with R-ISS...

Patient Profile: A 60-Year-Old Woman with Later Relapsed/Refractory Multiple Myeloma

On July 30, the U.S. Food and Drug Administration (FDA) approved daratumumab and hyaluronidase-fihj (Darzalex Faspro) in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for induction and consolidation in patients with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant (ASCT). PERSEUS. Efficacy was evaluated in PERSEUS...

FDA Approves Daratumumab and Hyaluronidase-fihj With VRd for Multiple Myeloma

A healthy 38-year-old who began struggling to finish a half-marathon and experienced night sweats, body aches, and COVID-like symptoms learned he was facing stage 4 non-Hodgkin lymphoma. Despite the shocking diagnosis, he plans to remain positive while he fights the cancer. Lymphoma is a blood cancer, specifically of the immune...

Fit, Healthy Man, 38, With Swollen Knee Felt Covid-Like Symptoms for a Month Before Learning He Had Stage 4 Non-Hodgkin Lymphoma

Chronic lymphocytic leukemia (CLL) is a type of cancer affecting a type of white blood cell in the blood and bone marrow. It often progresses slowly and is diagnosed most often during routine blood testing. Understanding the stages of CLL—from stage 0 to 4—can help you navigate a CLL diagnosis....

Stages of Chronic Lymphocytic Leukemia (CLL)

Thermo Fisher Scientific announced that it has received an extended 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its Optilite Freelite assays for evaluating monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma. MGUS is a lifelong condition characterized by the presence of abnormal...

Thermo Fisher Scientific gets FDA 510(k) clearance for multiple myeloma precursor assays

On the heels of game-changing trial results presented at last year's American Society of Hematology meeting, Johnson & Johnson is introducing what it calls a "foundational frontline therapy" in multiple myeloma and at the same time expanding its already impressive presence in the field. Late Tuesday, the company said the...

J&J touts new 'foundational' frontline multiple myeloma treatment as Darzalex Faspro nabs quadruplet FDA nod

The Food and Drug Administration has given the go-ahead for a late-stage clinical trial of an injectable stem cell product that could give new hope to millions of patients suffering from lower back pain caused by degenerative disc disease (DDD). Up to 400 patients with mild to moderate DDD are expected to enroll in the Phase 3 study later this year.

FDA Approves Stem Cell Study for Degenerative Disc Disease

Doctors monitor lymphocyte and other blood cell levels to predict how your lymphoma will progress. Low lymphocyte counts may suggest that cancer has spread to your bone marrow, or it can be a side effect of treatments. Lymphoma is a group of cancers that develop in your lymphocytes. These white...

Understanding Lymphocyte Levels in Lymphoma: Uses and Significance

102.5 The Bone

Patients now have a new option for colorectal cancer detection. The Food and Drug Administration approved a blood test that can detect colorectal cancer, CBS News reported. It’s called Shield and was developed by Guardant Health Inc. The test was approved by the FDA for adults aged 45 and...

FDA approves colorectal cancer blood test

Virginia State

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

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Cheryl E Preston

Jessica Serfitay flips the script on her previous statement. Virginia soap fans, Soap Opera News reports that Jessica Serfitay (ex Sloan Petersen) on Days of Our Lives posted on social media that her billionaire fiancé had abused her. The actress now says they argued as families do, and she never should have posted anything.

Days of Our Lives alum Jessica Serfitay retracts her statement that her fiance abused her

Omar Nadeem, MD, clinical director, Myeloma Cellular Therapies, Dana-Farber Cancer Institute, discussed GPRC5D-targeted CAR-T, BMS-986393. BMS-986393, a GPRC5D-targeted chimeric antigen receptor (CAR) T-cell therapy, was well-tolerated and yielded responses in patients with relapsed/refractory multiple myeloma and 1-to-3 lines of prior therapy, according to initial data from the phase 1 CC95266MM001 study (NCT04674813).

Assessing CAR T-Cell Therapy With Novel Targets for R/R Multiple Myeloma

Newark, NJ

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

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Morristown Minute

NEWARK, N.J. – An Essex County man has been charged with numerous offenses related to narcotics distribution and firearms trafficking. Kyrell Domnie, 39, of Irvington, known by the alias "Fly Ky," was charged by complaint and appeared before U.S. Magistrate Judge Cathy L. Waldor in Newark federal court on July 17, 2024. He remains detained following the hearing.

Convicted Felon Faces Multiple Narcotics and Firearms Charges

A multicenter, randomized, double-blind, placebo-controlled trial done performed in the the United Kingdom June 2014 to October 2017), enrolled 207 adult patients with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months, after an inadequate response to analgesic medications.

Pain Reduction with Methotrexate in Knee Osteoarthritis

Levels of glial fibrillary acidic protein (GFAP), a marker of damage to specific neuron-supporting cells, in the fluid surrounding the brain and spinal cord increase with the progression of Huntington’s disease, a study showed. Higher GFAP levels in the cerebrospinal fluid (CSF) were also significantly associated with more severe...

GFAP may be Huntington’s disease progression biomarker: Study

“Patients did great” with a four-drug regimen for multiple myeloma, an expert told CURE®. Patients with newly diagnosed multiple myeloma treated with the four-drug combination of Sarclisa (isatuximab), Kyprolis (carfilzomib), Revlimid (lenalidomide) and dexamethasone (a regimen known as Isa-KRd) experienced what researchers described as “deep and durable” responses, according to study findings.

Isa-KRd Elicits Responses in Some With Newly Diagnosed Multiple Myeloma

Colorado State

David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Arizona State

Arizona Luminaria

Kari Lake appears to have won the Republican primary for U.S. Senate with about two thirds of votes counted. She will face Democrat Ruben Gallego in the general election. In the Republican primary for U.S. House of Representatives District 6 — a swing district with a history of close elections that includes parts of Pima, Pinal, Cochise, Graham and Greenlee counties — incumbent Juan Ciscomani defeated challenger Kathleen Winn.

Live Arizona election results: Kari Lake and Juan Ciscomani win primaries

Results suggest cholesterol absorption inhibitors are linked to a lower risk of liver cancer, but no association was observed for other nonstatins like fibrates, omega-3 fatty acids, and niacin. Findings from a recent study are providing clinicians with an overview of the association between nonstatin cholesterol-lowering medications and the risk...

Cholesterol Absorption Inhibitors Linked to Reduced Liver Cancer Risk

The NCCN has updated its guidelines to recommend imetelstat as a top treatment for symptomatic anemia in lower-risk MDS, following its FDA approval based on encouraging phase 3 trial results. The National Comprehensive Cancer Network (NCCN) has revised its clinical practice guidelines in oncology for treating myelodysplastic syndromes (MDS). The...

NCCN Updates Guidelines to Recommend Imetelstat for Lower-Risk MDS Anemia Treatment

Denver, CO

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

NewsBreak

FDA Approves Daratumumab Plus VRd in Newly Diagnosed Multiple Myeloma

Findings from the phase 3 PERSEUS study support the approval of subcutaneous daratumumab and bortezomib, lenalidomide, and dexamethasone in this patient population. Daratumumab and hyaluronidase-fihj regimen...

FDA Approves Daratumumab Plus VRd in Newly Diagnosed Multiple Myeloma

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