Columbus, OH

A multicenter, randomized, double-blind, placebo-controlled trial done performed in the the United Kingdom June 2014 to October 2017), enrolled 207 adult patients with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months, after an inadequate response to analgesic medications.

Pain Reduction with Methotrexate in Knee Osteoarthritis

Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. It can progress slowly and may not cause many symptoms. Although it is treatable, it’s not considered to be curable. In the early stages, CLL often doesn't require treatment immediately, as studies have...

Chronic Lymphocytic Leukemia (CLL): When to Treat Cancer or Hold Off

Patients with inflammatory arthritis experiencing “long COVID” reported significantly worse disease activity. COVID-19 has demonstrated a substantial impact on patients with inflammatory arthritis, with those experiencing “long COVID” showing a significantly worse disease activity in addition to worse disability, pain, fatigue, and quality of life. Additionally, even those without long COVID had worse disease control when compared with patients without a history of a prior COVID-19 diagnosis.1.

Long COVID Linked to Significantly Worse Rheumatic Disease Activity

The Food and Drug Administration has given the go-ahead for a late-stage clinical trial of an injectable stem cell product that could give new hope to millions of patients suffering from lower back pain caused by degenerative disc disease (DDD). Up to 400 patients with mild to moderate DDD are expected to enroll in the Phase 3 study later this year.

FDA Approves Stem Cell Study for Degenerative Disc Disease

Healthline

Combining GLP-1 drugs like Ozempic with SGLT2 diabetes medications may help reduce the risk of heart attacks, stroke, and kidney disease, new research suggests.

Pairing Drugs Like Ozempic with SGLT2 Meds May Help Reduce Heart Attack, Stroke Risks

Results from the PERSEUS study led to the FDA approval of Darzalex Faspro in patients with newly diagnosed multiple myeloma who are eligible for an autologous stem cell transplant. The FDA has approved Johnson & Johnson’s (J&J) Darzalex Faspro in combination with bortezomib, lenalidomide, and dexamethasone (D-VRd) for patients with...

FDA Approves Johnson & Johnson’s Darzalex Faspro in Combination with Bortezomib, Lenalidomide, and Dexamethasone for Newly Diagnosed Multiple Myeloma

In the previous two columns, I discussed aneurysms that occur in the aorta situated in the chest cavity. In this article, I will explain the various types of treatment options available for those thoracic aortic aneurysms. In general, outcomes favor endovascular repair over open repair as open repair is associated...

3 Options for Thoracic Aortic Aneurysm Management

Treatment-induced neuropathy of diabetes (TIND) is a rare but potentially painful complication of diabetes caused by high blood sugar and nerve damage. Treatment-induced neuropathy of diabetes (TIND) is a little-known complication of diabetes that may affect up to 10% of individuals with diabetes. This acute condition occurs due to aggressive...

What to Know About Treatment-Induced Neuropathy of Diabetes (TIND)

The US Sun

A MAN diagnosed with a rare liver disease and inflammatory bowel disease (IBD) is receiving weekly poo transplants to treat the conditions in a world first. Rick Dallaway, from Birmingham, is the first person recruited in a trial testing whether faecal microbiota transplantation (FMT) can ease liver disease symptoms. Known...

Man becomes first in the world to receive weekly poo transplants to treat liver disease and IBD in ‘cutting edge’ trial

Denver, CO

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

contributor

David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

Interesting Engineering

Patients experienced a significant reduction in pain, improved their quality of life, and even showed signs of cartilage regrowth.

Stem cell shot reverses osteoarthritis, repairs knee cartilage, cuts pain by 58%

Cleveland, OH

Four months out from the actual surgery, the United States' first robot-assisted dual kidney transplant has been deemed a resounding success. The patient's health and comfort after the procedure lend robot-assisted transplant surgery an extra dose of credibility among those sitting on organ waiting lists. Joanne Kukula, a 70-year-old Ohio...

First Robot-Assisted Dual Kidney Transplant in the US Deemed a Success

When assessing optic nerve damage for detecting glaucoma, peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) are among the quintessential biomarkers. However, a new study published in Journal of Clinical Medicine considered the differences in OCTA-derived macular vessel density (VD) biomarkers in early to moderate primary open-angle glaucoma patients. They discovered a significantly reduced global, hemispheric and quadrant superficial capillary plexus (SCP) VD in the whole image, parafovea and perifovea, signaling that this metric may be just as useful in early detection of POAG as RNFL and GCC thickness.

SCP Macular Vessel Density as Accurate as RNFL, GCC Thickness in Diagnosing POAG

Reuters

(Reuters) -Trial results show Eli Lilly's weight loss drug Zepbound reduces the risk of hospitalization, death and other outcomes for obese adults with a common type of heart failure, the company said on Thursday as it continues to build a case for the medication's wider health benefits.

Lilly says weight loss drug cuts heart failure risk by 38% in trial

This extended-release injectable suspension for schizophrenia and schizoaffective disorder is approved as a monotherapy and as an adjunct to mood stabilizers or antidepressants. Luye Pharma Group announced on July 29, 2024, that the US Food and Drug Administration (FDA) approved paliperidone palmitate (ERZOFRI), an extended-release injectable suspension for the treatment...

FDA Approves Paliperidone Palmitate for Schizophrenia, Schizoaffective Disorder

Salt Lake City, UT

In advance of this year’s American Society for Preventive Cardiology (ASPC) 2024 Congress on CVD Prevention, we spoke with ASPC President-Elect Michael Shapiro, DO, FASPC, about the many can't-miss sessions at this year's record-breaking event. In advance of this year’s American Society for Preventive Cardiology (ASPC) 2024 Congress on...

ASPC Congress to Highlight Innovations in CVD Prevention

"The CF for 2025 is proposed to decrease to $32.36 from $33.29 in 2024. This is a decrease of 2.80%," write Jonathan Rubenstein, MD, and Mark Painter. On July 10, 2024, the Centers for Medicare & Medicaid Services (CMS) released the Calendar Year (CY) 2025 Medicare Physician Fee Schedule Proposed Rule. It outlines CMS’ proposed updates for payments and policies starting January 1, 2025. As always, there is a comment period after which CMS must respond and react to the comments received, which will be published in the Final Rule that is typically released in November. Comments can be posted online by going to the following website and submitting a formal comment. Please refer to file code CMS-1807-P and go to https://www.regulations.gov and follow the “Submit a comment” instructions. Below are some of the most notable proposed rules that may interest urologists and urology practices.

How the 2025 Medicare proposed rule may affect urology

A post hoc analysis of PHOTON showed the utility of aflibercept 8 mg in patients with DME, irrespective of baseline visual acuity. A post hoc analysis of the Phase 2/3 PHOTON trial demonstrated the visual and anatomic benefit of aflibercept 8 mg in patients with diabetic macular edema (DME), regardless of baseline best-corrected visual acuity (BCVA).

Diana Do, MD: Impact of Baseline BCVA on Aflibercept 8 mg Outcomes in DME

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

writer

Fareeha Arshad

Scientists are interested in the expanding use of Ozempic as its benefits extend beyond its original role as a diabetes treatment. Recent findings highlight its potential advantages for heart and kidney health, particularly in patients with type 2 diabetes and chronic kidney disease.

Ozempic May Lower Risk of Kidney and Heart Events in High-Risk Patients

AstraZeneca’s CALQUENCE (acalabrutinib) in combination with venetoclax, with or without obinutuzumab achieved the significant and clinically meaningful improvement in the AMPLIFY Phase III trial. AstraZeneca has shared positive, interim results from the AMPLIFY Phase III trial (NCT03836261) evaluating its CALQUENCE (acalabrutinib) in combination with venetoclax, with or without obinutuzumab...

Emerging Phase III Results Show CALQUENCE Regimen Significantly Improved Progression-free Survival in Leukemia Patients

NewsBreak

ATEV Meets Primary Endpoints in Phase 3 Trial for Arteriovenous Access in Hemodialysis

The acellular tissue engineered vessel met co-primary endpoints for function and patency at 6 and 12 months compared to autogenous fistula in patients on hemodialysis. Humacyte...

ATEV Meets Primary Endpoints in Phase 3 Trial for Arteriovenous Access in Hemodialysis

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