Columbus, OH

The advent of gene therapies for spinal muscular atrophy (SMA) has allowed some patients reach developmental milestones when treated as newborns, but the long-term durability of these treatments is unknown. Researchers recently tested a new approach in mice that combines both gene supplementation and genome editing to increase the likelihood of medical intervention lasting longer.

Combining Gene Therapy and Gene Editing Techniques to Bolster SMA Treatment

A range of conditions, including alcohol or medication overuse, nonalcoholic fatty liver disease (NAFLD), and chronic infections, can damage your liver. However, the early signs of liver damage are subtle, and the initial stages of liver disease are "silent," or asymptomatic. By the time you recognize symptoms, your liver is already significantly damaged.

Signs of Liver Damage and Ways to Tell

Denver, CO

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David Heitz

More dangerous substances are entering the Denver drug supply, Harm Reduction Action Center warned in a newsletter this week. “The Iron Law of Prohibition posits that as law enforcement becomes more intense, the potency of prohibited substances increases,” HRAC Executive Director Lisa Raville wrote in the newsletter. That is exactly what is happening, she said.

Dangerous substances entering Denver drug supply

South Carolina State

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Colleton County, SC

Explore Beaufort SC

Some beachgoers were in for a surprise this week when a bizarre looking prehistoric fish washed ashore in Colleton County along Edisto Beach at Edisto Beach State Park. It turned out to be an atlantic sturgeon.

Rare Atlantic sturgeon washes ashore on South Carolina beach

New York City, NY

TechSpot

Serving tech enthusiasts for over 25 years. What just happened? While there are many therapies available to treat diabetes, none have proven to completely reverse this disease. That may change as research from the Mount Sinai Health System and the City of Hope continues to progress. Researchers from these institutions have demonstrated a treatment that increases human insulin-producing beta cells in vivo for the first time, normalizing glucose levels in diabetic mice models. "It's very exciting to be close to seeing this novel treatment used in patients," said one of the researchers. "There is nothing like this available to patients right now."

New drug reverses diabetes in mice, boosting insulin-making cells by 700%

Kentucky State

Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

Interesting Engineering

Patients experienced a significant reduction in pain, improved their quality of life, and even showed signs of cartilage regrowth.

Stem cell shot reverses osteoarthritis, repairs knee cartilage, cuts pain by 58%

Multiple sclerosis (MS) is a disease that damages the nerves of the central nervous system. This damage disrupts nerve impulses and can lead to ataxia — a condition that affects coordination, balance, and speech. This article outlines the symptoms of ataxia. It also considers the prevalence of this condition...

What to know about ataxia in multiple sclerosis

The Conversation UK

Scientists in America have developed a nasal spray that can remove proteins in the brain associated with Alzheimer’s disease – at least, in mice. There are two proteins implicated in Alzheimer’s: amyloid and tau. Most of the drugs – included those recently approved by the US Food and Drug Administration (FDA) – focus on removing amyloid. To date, though, there has been little focus on removing tau “tangles”. However, the new nasal spray, developed by researchers at the University of Texas Medical Branch, focuses on this protein.

Nasal spray clears proteins linked to Alzheimer’s – new study

shefinds

Parkinson’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Characterized by tremors, stiffness, and difficulty with balance and coordination, the disease is primarily caused by the loss of dopamine-prod...

3 Supplements A Neuroscientist Swears By To Prevent Parkinson’s Disease: ‘Gives Your Brain The Raw Materials To Repair Itself’

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

Researchers found that adults with overweight or obesity lost more weight with tirzepatide than semaglutide in a head-to-head comparison of the medications using electronic medical records data. Results showed that a weight loss of 15% or higher was achieved by 42.3% of the tirzepatide group vs. 18.1% of the semaglutide...

Top in endocrinology: Tirzepatide vs. semaglutide; FDA rejects icodec for diabetes

The Lens

This year’s area of low oxygen in the Gulf of Mexico is larger than average, the National Oceanic and Atmospheric Administration (NOAA) announced on Thursday. The “dead zone” is approximately 6,705 square miles , as measured last week. Within NOAA’s 38 years of measuring the dead zone, this year’s assessment marks the 12th-largest area of low to no oxygen, which can kill fish and marine life.

Gulf ‘dead zone’ larger than average, larger than expected for 2024, scientists announce

Months after actor and comedian Robin Williams took his own life in August 2014, autopsy results revealed he had a devastating disease: Lewy body dementia (LBD). Unlike Alzheimer's disease and even frontotemporal dementia, this brain disorder has tended to hide in the shadows. But work is underway to change that, says Dr. Stephen Gomperts, an assistant professor of neurology at Harvard Medical School and director of the Lewy Body Dementia Unit at Harvard-affiliated Massachusetts General Hospital.

What is Lewy body dementia?

Colorado State

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Herbie J Pilato

Hollywood child stardom has taken its toll on many actors through the decades. Lani O'Grady, for one, found fame in the 1970s on the TV family series, Eight is Enough. O'Grady followed in the footsteps of her brother, actor Don Grady, an original Mouseketeer and member of another popular TV family show: My Three Sons. Their mother, Mary B. Grady, was a talent agent who represented several child actors. But Lani, who would also eventually become an agent, died in 2001 just one week before what would have been her 47th birthday.

TV's 'Eight is Enough' Star Lani O'Grady Found Fame Early in Life but Died a Tragic Death

Researchers at Nagoya University have developed a novel compound that could revolutionize the treatment of lipid disorders. The drug, named ZTA-261, targets the thyroid hormone receptor beta (THRβ) with unprecedented selectivity, potentially offering a safer and more effective approach to managing conditions like dyslipidemia. A Targeted Approach to Lipid...

New Thyroid Hormone Drug Shows Promise for Treating Lipid Disorders with Fewer Side Effects

This marks the first approval of a systemic therapy for patients with grade 2 astrocytoma or oligodendroglioma with an IDH1 or IDH2 mutation. The FDA approved vorasidenib (Voranigo) for the treatment of adult and pediatric patients aged 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation who have undergoing biopsy, subtotal resection, or gross total resection.

FDA Approves Vorasidenib to Treat Grade 2 Astrocytoma, Oligodendroglioma With IDH1, IDH2 Mutations

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

A study reveals that brain inflammation leads to the release of a protein that impairs muscle function, suggesting potential treatments for related muscle fatigue in diseases like Alzheimer’s and long COVID. Infections and neurodegenerative diseases are known to cause brain inflammation. However, patients with brain inflammation often develop muscle...

Hidden Connection Discovered: New Research Links Brain Inflammation to Muscle Fatigue

NewsBreak

Double gene therapy leads to lasting benefits in SMA mouse model

A combination genetic therapy approach designed to restore more normal activity of the SMN1 gene improved motor function and prolonged survival in a spinal muscular atrophy...

Double gene therapy leads to lasting benefits in SMA mouse model

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