Notre Dame vs. Purdue odds, line, picks, bets: 2024 college football Week 3 predictions from proven model

The biggest upset of the 2024 college football season up to this point occurred last weekend when Notre Dame lost to Northern Illinois, 16-14, in South Bend. Notre Dame was favored by more than four touchdowns in that contest. Notre Dame dropped from No. 5 to No. 18 in the country as the Fighting Irish look to return to their winning ways against the Purdue Boilermakers on Saturday. Purdue defeated Indiana State, 49-0, on August 31 in its only game of the season.

Kickoff is scheduled for 3:30 p.m. ET on Saturday at Purdue's Ross-Ade Stadium in Indiana. Notre Dame is a 9.5-point favorite in the latest Notre Dame vs. Purdue odds via SportsLine consensus, while the over/under for total points scored is 47.5. Before making any Purdue vs. Notre Dame picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model .

Saturday's game can be seen live on CBS and streamed live on Paramount+ , which you can now get for 50% off your first year plus a 7-day free trial (valid through 9/22/24).

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

Now, the model has dialed in on Notre Dame vs. Purdue and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks . Here are the college football odds and trends for Purdue vs. Notre Dame:

• Notre Dame vs. Purdue spread: Fighting Irish -9.5
• Notre Dame vs. Purdue over/under: 47.5 points
• Notre Dame vs. Purdue money line: Notre Dame -362, Purdue +284
• Notre Dame vs. Purdue picks: See picks here
  
• Notre Dame vs. Purdue streaming: Paramount+ (get 50% off first year of annual plan now through 9/22/24)

Why Notre Dame can cover

Despite last weekend's upset loss, Notre Dame opened the season with a 23-13 victory over No. 20 Texas A&M at College Station. Notre Dame was 10-1 over its last 11 games against unranked teams coming into last weekend, winning those 10 games by an average of 32.9 points. The Fighting Irish last played Purdue in 2021 and won 27-13 at home and Notre Dame has won six straight games against Purdue by an average of 12.4 points.

The Fighting Irish have one of the most dominant defenses in the country, allowing just 14.5 points per game this season. Notre Dame forced two turnovers in the win over Texas A&M. Although Notre Dame is averaging just 18.5 points per game this season, that's no fault of sophomore running back Jeremiyah Love , who has rushed for 170 yards on 6.8 yards per carry over Notre Dame's first two games. See picks at SportsLine .

Why Purdue can cover

Purdue had a dominant opening showing in its 49-0 victory over Indiana State, an FCS school. Returning starting quarterback Hudson Card had a near-perfect performance in Week 1 of the season. He completed 24 of 25 passes for 273 yards and four touchdowns in the victory. The fifth-year senior threw for 2,387 yards and 15 touchdowns with eight interceptions last year after spending his first three years at Texas . The Purdue defense matched the offense's efficiency, allowing just 154 total yards in the shutout.

Purdue has had ample time to scout and game plan for Notre Dame. They scheduled a weaker first opponent and followed it with a bye last week in hopes of knocking off Notre Dame for the first time since 2007. But Notre Dame showed offensive deficiencies last week against Northern Illinois with a passing attack still developing chemistry with quarterback Riley Leonard transferring in from Duke. Leonard hasn't thrown a touchdown in either of his first two games and if the Purdue defense can frustrate him, the Boilermakers can cover the number on Saturday. See picks at SportsLine .

How to make Notre Dame vs. Purdue picks

SportsLine's model is leaning Over on the total, projecting 51 combined points. It also says one side of the spread hits well over 50% of the time. You can see the model's pick at SportsLine .

So who wins Purdue vs. Notre Dame, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception , and find out, and don't forget to stream on Paramount+ .