Self-learning AI releases NFL against the spread, over-under, money-line picks for each 2024 Week 2 game

The Dallas Cowboys and New Orleans Saints cruised to blowout wins in their season-openers, setting up a showdown on Sunday during the Week 2 NFL schedule. New Orleans is playing under new offensive coordinator Klint Kubiak, who engineered a game plan that resulted in a 47-10 win over Carolina last week. However, the Saints are 6.5-point underdogs against the Cowboys in the Week 2 NFL odds. Should you back the NFL underdogs in that game with your Week 2 NFL best bets? There are five other Week 2 NFL spreads that are larger than six points, with the Ravens (-8.5 vs. Raiders) the heaviest favorites of the week.

Baltimore had extra time to prepare for this game after losing to Kansas City to open the season, while Las Vegas managed just 10 points in its loss to the Chargers. Before you make any Week 2 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI .

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 2, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 2 NFL schedule here .

Top Week 2 NFL AI picks

After analyzing every game in Week 2, the AI PickBot says the Jaguars cover as three-point favorites at home against the Browns . Cleveland was without a pair of starting offensive linemen in Jedrick Wills Jr. (knee) and Jack Conklin (knee) in a season-opening loss to Dallas, and they are both questionable for this game. The Browns struggled to protect quarterback Deshaun Watson, who threw for one touchdown and two interceptions with a 53.3% completion rate.

Watson did not complete any of his 10 pass attempts of 15-plus yards, which was the worst performance by any quarterback since air yards started getting tracked in 2006. Jacksonville has more offensive weapons than Cleveland, as quarterback Trevor Lawrence has some elite new targets in Gabe Davis and Brian Thomas Jr. The AI PickBot expects Jacksonville to come up with some key plays on Sunday, ultimately covering the spread against the struggling Cleveland offense. See its other Week 2 football predictions and football picks at SportsLine .

How to make Week 2 NFL picks

In addition, the AI PickBot has generated five A-rated picks for Week 2. You need to see the AI PickBot's picks before making any Week 1 NFL bets of your own. You can only see it at SportsLine .

Who wins and covers each Week 2 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season .