San Francisco 49ers vs. Minnesota Vikings: Week 2 preview and predictions

The Minnesota Vikings are looking for their first 2-0 start since 2016 as they take on the San Francisco 49ers on Sunday afternoon . They are also looking to keep another streak as the Vikings are looking for their eighth-consecutive win against the 49ers in the state of Minnesota.

As we look toward the game on Sunday, the Vikings will be without wide receiver Jordan Addison and the 49ers will be without running back Christian McCaffrey. Despite the injuries, both teams have offenses that can gash you for chunk plays and put points up on the board.

Going into Sunday, here is our ultimate preview of the game.

Preview content

Injuries shaping Vikings
Broadcast map
Aaron Jones and the SKOL chant
Justin Jefferson on Jalen Nailor
Vikings' keys to the game
Vikings' injury report
How Vikings will deal without Jordan Addison
49ers to be without star player
Sam Darnold bulletin board material
49ers questions

Game information

Kickoff : 12 p.m. CT

Location : U.S. Bank Stadium, Minneapolis, MN

Weather : Indoors

Keys for the Minnesota Vikings

• Establish the running game
• Get Jalen Nailor involved
• Stop the run to minimize play-action
• Don't miss tackles

Keys for the San Francisco 49ers

Get Jordan Mason involved early
Play-action needs to be a priority
Get pressure on Sam Darnold

Betting odds via DraftKings Sportsbook

Spread : 49ers -4.5

Over/under : 46.0

Moneyline : Vikings +180, Giants -218

Prediction

What are the Vikings in their current iteration? We saw Darnold look to begin a renaissance but was that a one-week aberration? The 49ers look to be a complete team with weapons galore to attack the Vikings defense. This game will be close but the Vikings come up just short.

Prediction : 49ers 24, Vikings 20

Related: San Francisco 49ers defender trash talks Sam Darnold, gives Minnesota Vikings bulletin board material