Notre Dame vs. Louisville odds, spread, line: 2024 college football picks, Week 5 predictions by proven model

A Top 25 showdown is set to take center stage on Saturday when the No. 16 Notre Dame Fighting Irish host the No. 15 Louisville Cardinals . The Fighting Irish are coming off a 28-3 victory over Miami (OH), while the Cardinals secured a 31-19 win over Georgia Tech in their last outing. Notre Dame has won 13 of its last 15 meetings against an opponent from the ACC, while Louisville is 8-0 in its last eight games played in September.

Kickoff at Notre Dame Stadium is set for 3:30 p.m. ET. The Fighting Irish are 6.5-point favorites in the latest Louisville vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 46. Before making any Notre Dame vs. Louisville picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model .

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, the model has set its sights on Notre Dame vs. Louisville . You can head to SportsLine to see its picks . Here are several college football betting lines on the spread , money line and over/under for Louisville vs. Notre Dame:

• Louisville vs. Notre Dame spread: Notre Dame -6.5
• Louisville vs. Notre Dame over/under: 46 points
• Louisville vs. Notre Dame money line: Notre Dame -265, Louisville +211
• Louisville vs. Notre Dame picks: See picks at SportsLine

Why Notre Dame can cover

The Fighting Irish are led by their stifling defense. Notre Dame is giving up just 9.75 points per game this season, which ranks 10th in the nation. Defensive lineman Boubacar Traore has already racked up three sacks, one interception and one touchdown this season. In last week's victory over Miami (OH), Notre Dame gave up only three points and held RedHawks quarterback Brett Gabbert to just 119 passing yards.

Offensively, the Fighting Irish feature one of the nation's most dynamic rushing attacks. Running back Jeremiyah Love leads the team with 339 rushing yards. He's averaging a whopping 7.4 yards per carry and has scored four rushing touchdowns this season. Notre Dame averages 238.2 rushing yards per game, the 18th-best mark in college football. See which team to pick here .

Why Louisville can cover

The Cardinals are extremely explosive on offense, averaging 47.3 points per game, which ranks 12th in the country. Louisville is led by quarterback Tyler Shough , who's completing 68.4% of his passes for 850 yards, eight touchdowns and zero interceptions. In last week's win over Georgia Tech, Shough completed 13 of 19 passes for 269 yards and two touchdowns.

Defensively, Louisville has been tough to break down. The Cardinals are giving up just 268.7 yards per game on average, which ranks 22nd in college football. In addition, Louisville secured a 33-20 victory over the Fighting Irish in 2023, so the Cardinals will be confident they can pull off the upset on Saturday. See which team to pick here .

How to make Louisville vs. Notre Dame picks

The model has simulated Notre Dame vs. Louisville 10,000 times and the results are in. The model is leaning Over the total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine .

So who wins Louisville vs. Notre Dame, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced computer model that's up over $2,000 on its top-rated college football spread picks since its inception , and find out.