Big Ten Week 6 College Football Predictions, Schedule, and Odds

The Big Ten college football weekend starts in Eugene with a fun game of green between Michigan State and Oregon, and closes out with USC making a trip to Minneapolis to deal with a plucky Minnesota win that desperately needs a win.

In between it's all Big Ten all the time.

Rutgers going to Nebraska might actually be the most interesting game of the weekend, but Iowa at Ohio State will be an interesting test for the Buckeyes, and there's a national championship rematch when Michigan goes to Washington.

Here's the Week 6 slate of Big Ten games along with the latest lines, where to watch, and game previews.

Big Ten Week 6

Friday, October 4, 2024

Michigan State at Oregon

9:00 pm ET, FOX
Line: Oregon -24, o/u: 52.5
Game Preview & Prediction

Saturday, October 5, 2024

UCLA at Penn State

12:00 pm ET, FOX
Line: Penn State -28, o/u: 46.5
Game Preview & Prediction

Purdue at Wisconsin

12:00 pm ET, BTN
Line: Wisconsin -14, o/u: 46.5
Game Preview & Prediction

Iowa at Ohio State

3:30 pm ET, CBS
Line: Ohio State —20.5, o/u: 44.5
Game Preview & Prediction

Indiana at Northwestern

3:30 pm ET, BTN
Line: Indiana -13.5, o/u: 41.5
Game Preview & Prediction

Rutgers at Nebraska

4:00 pm ET, FS1
Line: Nebraska -7, o/u: 41.5
Game Preview & Prediction

Michigan at Washington

7:30 pm ET, NBC
Line: Washington -2.5, o/u: 41.5
Game Preview & Prediction

USC at Minnesota

7:30 pm ET, BTN
Line: USC -8.5, o/u: 51.5
Game Preview & Prediction

Week 6 CFN Expert Picks
Texas St at Troy | Sam Houston at UTEP
Houston at TCU | Michigan St at Oregon
Syracuse at UNLV | UCLA at Penn State
Missouri at Texas A&M | SMU at Louisville
Iowa at Ohio State | Auburn at Georgia
Ole Miss at So Carolina | Rutgers at Neb
Clemson at Florida St | Tenn at Arkansas
Michigan at Washington | Miami at Cal
Texas Tech at Arizona