Florida State vs. Clemson odds, spread, line: 2024 college football picks, Week 6 predictions from top model

The No. 15 Clemson Tigers (3-1) will play their first true road game of the season when they face the Florida State Seminoles (1-4) on Saturday night. Clemson opened the campaign with a blowout loss to Georgia, but it has responded with a three-game winning streak. Florida State is amid a disastrous campaign, dropping four of its first five games. The Seminoles have lost two of those games by double digits, including a 42-16 setback at SMU last week.

Kickoff is set for 7 p.m. ET on Saturday at Bobby Bowden Field at Doak Campbell Stadium. Clemson is favored by 14.5 points in the latest Florida State vs. Clemson odds, while the over/under is 46.5 points, per SportsLine consensus. Before entering any Clemson vs. Florida State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread . It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

The model has set its sights on Clemson vs. FSU . You can head to SportsLine to see its picks. Here are several college football betting lines for the spread , money line and over/under :

• Florida State vs. Clemson spread: Clemson -14.5
• Florida State vs. Clemson over/under: 46.5 points
• Florida State vs. Clemson money line: Clemson -671, FSU +471
• Florida State vs. Clemson picks: See picks here
• Florida State vs. Clemson streaming: FuboTV (Try for free)

Why Florida State can cover

Florida State has been competitive in its last two home games, losing to Memphis by eight points before beating California . The Seminoles covered the spread as 2.5-point favorites, as senior running back Lawrance Toafili rushed for 80 yards and a touchdown. They struggled on the road in their ensuing game,  but it came on the road against a high-scoring opponent.

Seminoles quarterback DJ Uiagalelei has been a major disappointment this season, so perhaps a new quarterback will give the team a jolt. Sophomore Brock Glenn is expected to make his first start of the season, as Uiagalelei suffered a broken finger on his throwing hand and is likely to miss multiple games. Florida State has won 10 of its last 12 home games. See which team to pick here.

Why Clemson can cover

Clemson has completely turned its season around following its blowout loss to Georgia, winning three straight games in dominant fashion. The Tigers covered the spread in all three of those contests, including their 40-14 win over Stanford last week. Junior quarterback Cade Klubnik had 255 passing yards and five total touchdowns in that game.

He now has 984 passing yards and 12 passing touchdowns, throwing at least three scores in each of his last three games. Senior running back Phil Mafah has 43 carries for 342 rushing yards and two touchdowns, averaging 8.0 yards per carry. The Tigers have covered the spread in seven of their last nine games, and they have covered in five of the last six meetings between these teams. See which team to pick here.

How to make Florida State vs. Clemson picks

The model has simulated Clemson vs. Florida State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Florida State vs. Clemson, and which side of the spread is hitting 60% of the time? Visit SportsLine now to see which side of the Clemson vs. Florida State spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception , and find out.