Kirk Herbstreit Predicts Major Top 15 College Football Upset in Week 6

No. 12 Ole Miss (4-1) will take on South Carolina (3-1) on Saturday afternoon for an SEC battle.

Lane Kiffin's Rebels are looking to bounce back following a dismal showing against Kentucky last week in Oxford. Ole Miss and star quarterback Jaxson Dart struggled to move the ball against the stout Wildcats defense, scoring just 17 points to fall 20-17 as the No. 6 team in the country.

On the other side, the Gamecocks are coming off a dominant showing against Akron. Auburn transfer quarterback Robby Ashford threw for 243 yards and two touchdowns in his first start at South Carolina.

The Rebels are currently listed as 10-point favorites over the Gamecocks, per ESPN Bet. But ESPN "College GameDay" host Kirk Herbstreit sees an upset on the horizon in Columbia.

Herbstreit predicted Ole Miss to fall to South Carolina when making his picks on Saturday morning, calling for the Rebels to lose twice in as many weeks.

If the Gamecocks are able to pull off the upset, it would be a major blow to Kiffin and company. Already having an SEC loss, another conference blemish would likely end SEC championship hopes in Oxford with teams like No. 13 LSU and No. 5 Georgia still on the upcoming slate.

South Carolina and head coach Shane Beamer came close to upsetting LSU in Week 3. The Gamecocks had a fourth quarter lead before allowing a late comeback by the Tigers. The question against the Rebels is who will be under center, as LaNorris Sellers is listed as probable ahead of kickoff.

The game is set for 3:30 p.m. ET on ESPN at Williams-Brice Stadium.

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