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The Buffalo Bills take on the New York Jets in East Rutherford, New Jersey, but will be without star running back James Cook in this Week 6 matchup. This is going to have a significant impact on the game as the Buffalo Bills depend on him to help take pressure off quarterback Josh Allen. Plus, with the lead of the AFC East on the line, this game means a lot in terms of the standings. Let's take a look at exactly what this means for the Buffalo Bills as they get ready for the game kicking off in less than 90 minutes.

James Cook Out with Toe Injury

ESPN's Adam Schefter is reporting that the Buffalo Bills are going to be without running back James Cook as he is dealing with a toe injury. The Buffalo Bills are going to take a massive hit in their running game as James Cook has 70 carries for 309 yards (4.4 yards per attempt) with four rushing touchdowns on the year. He also has been a steady pass-catcher out of the backfield as he has 11 receptions for 123 yards (11.2 yards per catch) and a receiving touchdown.

This is the first game of James Cook's three-year NFL career that he is missing due to injury and this will put more pressure on Josh Allen as a result. Cook leads the team in rushing and Josh Allen is the only other player on the roster with at least 80 rushing yards this year. The New York Jets are second in the sport with 255.8 yards per game allowed and with interim coach Jeff Ulbrich being a defensive-minded coach, this will be an interesting test for the Buffalo Bills to move the ball without their top running back.

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Article originally written by Vincent Pensabene