The Sisterhood stages their takeover in the epic trailer for Dune: Prophecy, HBO’s upcoming sci-fi prequel series to Dune. Set 10,000 years before Paul Atreides’ rise to power, Dune: Prophecy stars Emily Watson as Valya Harkonnen, the leader of the Sisterhood. Olivia Williams plays Tula Harkonnen, Valya’s sister. Together, the Harkonnen sisters fight to save the future of humankind and establish the powerful sect that will become known as the Bene Gesserit.