In patients with muscle-invasive bladder cancer (MIBC), neoadjuvant durvalumab combined with neoadjuvant cisplatin-based chemotherapy outperformed neoadjuvant chemotherapy alone in the phase 3 NIAGARA trial. Neoadjuvant chemotherapy followed by radical cystectomy improves overall survival (OS) versus cystectomy alone in patients with MIBC and has been recommended for the past 40 years1....