Curcuma-containing supplements are thought to work through inhibition of the classical and alternate pathway on complement inhibition. Click image to enlarge. JAMA Ophthalmology has published exciting research about a possible way to prevent age-related macular degeneration (AMD). The plant Curcuma longa, from which the spice turmeric derives, is sometimes used as a remedy for various ailments throughout South Asia. Over-the-counter dietary supplements that contain curcuma have been touted as a way to combat numerous age-related diseases due to its natural anti-inflammatory and antioxidant agents. Recently, researchers investigated curcuma-based nutritional supplements (CBNS) to see if these properties may have any association with risk of development or progression of AMD.