Yair Lotan, MD, discusses factors informing treatment selection for patients with BCG-unresponsive non-muscle invasive bladder cancer. Yair Lotan, MD, professor, urology, chief, Urologic Oncology; Jane and John Justin Distinguished Chair in Urology, UT Southwestern Medical Center; medical director, Urology Clinic, UT Southwestern, Parkland Health and Hospital System, discusses factors informing treatment selection for patients with Bacillus Calmette–Guérin (BCG)–unresponsive non-muscle invasive bladder cancer (NMIBC).