<body><div><img src="https://img.particlenews.com/image.php?type=thumbnail_580x000&amp;url=2ofWvj_0wPwvG5D00" alt="https://img.particlenews.com/image.php?url=2ofWvj_0wPwvG5D00" width="2000" height="1133" >BOSTON—Laryngeal angioedema can occur in patients with hereditary angioedema with normal C1 inhibitor, reported an e-poster presentation at the 2024 American College of Allergy, Asthma and Immunology Annual Scientific Meeting.The case series presentation was inspired, in part, by an insurer’s refusal to cover prophylactic therapy for patients with normal C1 inhibitor, citing a lack of literature on laryngeal events in patients.“Hence we aim to describe severe laryngeal angioedema events as common in our cohort and in fact the presenting angioedema event,” wrote an author team from Grand Rapids, Michigan, in the abstract.The case series, which also aimed to inform treating clinicians, described a family with HAE with normal c1 inhibitor secondary to plasminogen gene defect. The abstract focused on 2 adult patients—son and father—whose primary presentation was laryngeal angioedema requiring intubation.Read more about the etiology of hereditary angioedemaThe son had 4 laryngeal angioedema events that required intubation when he was 37 years old. The father presented at 64 years old with 1 severe laryngeal angioedema event that required intubation, the authors reported. Neither had experienced any previous angioedema.Both patients’ lab workups were consistent with HAE with normal C1 inhibitor, and genetic testing confirmed a plasminogen gene defect.“Hereditary angioedema with normal c1 inhibitor secondary to plasminogen defect,” the authors concluded, “can have a delayed primary presentation of laryngeal angioedema.”</div></body>

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Laryngeal Angioedema Possible With Normal C1 Inhibitor

BOSTON—Laryngeal angioedema can occur in patients with hereditary angioedema with normal C1 inhibitor, reported an e-poster presentation at the 2024 American College of Allergy, Asthma and Immunology Annual Scientific Meeting. The case series presentation was inspired, in part, by an insurer’s refusal to cover prophylactic therapy for patients with...