First look: Louisville at Clemson odds and lines

The Louisville Cardinals (5-3, 3-2 ACC) visit the 8th-ranked Clemson Tigers (6-1, 5-0) Saturday night. Kickoff from Memorial Stadium is scheduled for 7:30 p.m. ET (ESPN). Below, we look at Louisville vs. Clemson odds from BetMGM Sportsbook's college football odds before making our expert college football picks and predictions later in the week.

Louisville got back in the win column Saturday with a 31-27 win at Boston College, but the Cardinals failed to cover as 7-point road favorites. QB Tyler Shough went 28 of 38 for 332 passing yards with 2 TDs and 2 interceptions in the win.

Clemson is coming off a bye week after extending its winning streak to 6 games with a 48-31 victory over Virginia Oct. 19th, while failing to cover as a 20.5-piont home favorite. QB Cade Klubnik went 23 of 35 for 308 yards with 3 TDs and an interception in the win.

- Rankings : US LBM Coaches Poll , conducted by the American Football Coaches Association and USA TODAY Sports

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Louisville at Clemson odds

Provided by BetMGM Sportsbook ; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds . Lines last updated Tuesday at 3:30 a.m. ET.

• Moneyline (ML) : Louisville +310 (bet $100 to win $310) | Clemson -400 (bet $400 to win $100)
• Against the spread (ATS) : Louisville +10.5 (-110) | Clemson -10.5 (-110)
• Over/Under (O/U) : 61.5 (O: -110 | U: -110)

2024 betting stats

• ML : Louisville 5-3 | Clemson 6-1
• ATS : Louisville 3-5 | Clemson 4-3
• O/U : Louisville 6-2 | Clemson 3-4

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Louisville vs. Clemson head-to-head

Louisville and Clemson have faced off 8 times in program history dating back to 2014 with Clemson dominating the series 8-0.

The last time the teams played was in November 2022 with Clemson taking down Louisville 31-16 and covering as a 7-point home favorite. The Under (52) narrowly hit with both teams combining for 839 yards of total offense -- Clemson 439, Louisville 400.

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This article originally appeared on USA Today Sportsbookwire: First look: Louisville at Clemson odds and lines