Dr Sekeres discusses how he approaches second-line therapy selection in ESA-refractory, transfusion-dependent lower-risk MDS (LR-MDS) patients, specifically with imetelstat. Please discuss how you approach second-line therapy selection in ESA-refractory, transfusion-dependent lower-risk MDS (LR-MDS) patients. (IMETELSTAT)

Second-Line Therapy for ESA-Refractory, Transfusion Dependent Lower-Risk MDS: Imetelstat

A multicenter, randomized, double-blind, placebo-controlled trial done performed in the the United Kingdom June 2014 to October 2017), enrolled 207 adult patients with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months, after an inadequate response to analgesic medications.

Pain Reduction with Methotrexate in Knee Osteoarthritis

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Ohio State

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The Lantern

On Tuesday, licensed Ohio dispensaries began legally selling non-medical marijuana to consumers; however, the drug’s possession, growth and/or usage are still prohibited on Ohio State’s campus. Credit: Jefferee Woo/Tampa Bay Times/TNS [Original caption: Four citizen-led petitions with proposals to update Dallas’ charter hit the 20,000 valid signature threshold to make it on the Nov. 5 election ballot, including one that would ban police officers from arresting or citing people carrying less than four ounces of marijuana.] As of Tuesday, students 21 and older can now legally purchase marijuana in Ohio.

Dispensary sales of recreational marijuana began Tuesday; possession and usage still prohibited on Ohio State’s campus

Raleigh, NC

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Town Talks

Big cities are known for their hustle and bustle, drawing people in who crave excitement, variety, and entertainment. But bigger isn’t always better, or at least not for Raleigh, North Carolina.

North Carolina City Named The Most Boring Town in the State

WEDNESDAY, Aug. 7, 2024 (HealthDay News) — For patients with preoperative iron deficiency anemia (IDA), intravenous (IV) iron treatment is associated with a significant reduction in 30-day postoperative mortality and morbidity compared with red blood cell (RBC) transfusion, according to research published online July 22 in Anesthesia & Analgesia.

Preoperative IV Iron Treatment Better for Iron Deficiency Anemia

Weston, FL

Akeena

If Mangia & Bevi Pizzeria Napoletana in Weston has been on your radar, you might want to know about some recent hiccups they’ve encountered. The pizzeria was ordered to close on July 29, and here’s what the health inspectors found:

Florida Pizzeria closed for 14 Violations- Employee touching ready-to-eat food with their bare hands

According to experts at the Cleveland Clinic, “When it comes to testosterone levels, odds are you don’t measure up to your father. Studies show that age-specific testosterone levels in men have been in a slow and consistent decline for several decades.”. In other words, the average level of...

3 health conditions that steal your testosterone

South Carolina State

Explore Beaufort SC

The mantis shrimp is one tough customer. Beautiful and deadly are two words you don’t typically use to describe shrimp, but the mantis shrimp is definitely in a class of its own; earning a reputation as the ‘savage boxer of the sea’ and one of the most fearsome creatures in the ocean. And, they're right at home here in South Carolina.

Savage Boxer of the Sea: The Deadly Beauty of Mantis Shrimp

Denver, CO

David Heitz

More dangerous substances are entering the Denver drug supply, Harm Reduction Action Center warned in a newsletter this week. “The Iron Law of Prohibition posits that as law enforcement becomes more intense, the potency of prohibited substances increases,” HRAC Executive Director Lisa Raville wrote in the newsletter. That is exactly what is happening, she said.

Dangerous substances entering Denver drug supply

Statin use was linked with increased glaucoma likelihood in the overall adult All of Us Research Program population with hyperlipidemia, in individuals with optimal or high LDL-C levels, and in individuals from 60 to 69 years old. A team of researchers has investigated links between statin use and glaucoma in...

Study links statin use to higher risk of glaucoma

NewsNinja

A lady is cautioning others about purchasing budget earrings from Amazon, Shein, and H&M, after she experienced keloid formations on her earlobes due to wearing them. On a TikTok post that has garnered more than 334,000 likes, Sailor Rozema (@sailor.rozema), a content creator, shares a warning with her community of "dangly earring girls": the inexpensive jewelry found in fast fashion can have negative impacts on your well-being.

‘I’ll never be wearing earrings for the rest of my life’: Customer warns against buying from Shein

Anesthesiology and Pain Management, Orthopedics, Surgery and Surgical Specialties. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

Modic changes in patients with lumbar disc herniation followed more than 1 year after lumbar discectomy: a systematic review and meta-analysis

Patients with a urine albumin-creatinine ratio of at least 3,500 mg/g had high rates of hyperkalemia. High rates also occurred in patients prescribed steroidal mineralocorticoid receptor antagonists. Hyperkalemia may be considered a common occurrence in patients with chronic kidney disease, particularly in those with heart failure or diabetes, published data...

Study: Urine albumin-creatinine ratio linked to hyperkalemia in patients with CKD

In the last 6 months prior to PDAC diagnosis, visceral and subcutaneous adipose tissue decreased by 12.9% and 14.7%, respectively. LDL, total cholesterol and triglycerides also decreased before diagnosis. In the 36 months prior to diagnosis of pancreatic ductal adenocarcinoma, researchers observed “predominant changes” in patients’ body composition and biochemical...

Body fat, metabolic changes before pancreatic cancer diagnosis may aid in early detection

Massachusetts State

Camilo Díaz

(MA) Meet Winks, an adorable and incredibly strong puppy with a heartbreaking origin. Winks was found unmoving on the side of a road with severe injuries. He had several very infected wounds and was barely holding on when his rescuers rushed him to the vet. Once there, x-rays revealed the horrifying truth that Winks had been shot numerous times around his face and neck. These injuries resulted in him having his eye removed. Despite that, Winks has made a miraculous and full recovery. He certainly does not let his handicap slow him down at his new foster home. Winks was truly given a second chance at life, and now all he needs is a family to call his own.

10-Month-Old Dog Who Was Hit In Face Several Times Now Searching For Family

Study shows patients 80 years and older with atrial fibrillation treated with a lower dose of edoxaban experienced fewer major gastrointestinal bleeding events for each additional ischemic stroke. Patients aged 80 years and above with atrial fibrillation (AF) may gain a benefit from treatment with lower-dose anticoagulants regardless of existing...

Phase III Trial Shows Older Patients with Atrial Fibrillation May Benefit From Lower-Dose Anticoagulants

Florida State

Uncovering Florida

With hurricane season posing a consistent threat six months out of the year, who would not like a little help getting their home ready for the harsh weather to come? Senate Bill 7028: My Safe Florida Home Program, approved by Governor DeSantis on April 24, 2024, and effective as of July 1, appropriates a one-time total of $200 million from 2024 to 2025 for the purpose of funding hurricane mitigation grants and inspections, as well as outreach and administration costs, to support homeowners in Florida.

DeSantis Signs New Bill Giving $200 Million To Homeowners

The FDA cleared the SeCore CDx HLA A Sequencing System as a companion diagnostic for afamitresgene autoleucel in advanced synovial sarcoma. The FDA has granted 510(k) clearance to the SeCore™ CDx HLA A Sequencing System for use as a companion diagnostic for afamitresgene autoleucel (afami-cel; Tecelra) in select adult patients with unresectable or metastatic synovial sarcoma.1.

FDA Clears Companion Diagnostic for Afami-Cel in Pretreated Metastatic Synovial Sarcoma

A stent thrombosis is a blood clot that forms within a coronary stent. It can be a complication of stent placement to open a narrowed artery. A coronary stent is a mesh tube that opens a narrowed or blocked artery to restore blood flow to the heart. A stent thrombosis...

What is a stent thrombosis following stent placement?

NewsBreak

Second-Line Therapy for ESA-Refractory, Transfusion Dependent Lower-Risk MDS: Luspatercept

Dr Sekeres discusses how he approaches second-line therapy selection...

Second-Line Therapy for ESA-Refractory, Transfusion Dependent Lower-Risk MDS: Luspatercept

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