Journal of Translational Medicine volume 22, Article number: 757 (2024) Cite this article. Multi-drug resistance of poly(morpho)nuclear giant cells (PGCs) determines their cytoprotective and generative potential in cancer ecosystems. However, mechanisms underlying the involvement of PGCs in glioblastoma multiforme (GBM) adaptation to chemotherapeutic regimes remain largely obscure. In particular, metabolic reprogramming of PGCs has not yet been considered in terms of GBM recovery from doxorubicin (DOX)-induced stress.

Metabolic reprogramming of poly(morpho)nuclear giant cells determines glioblastoma recovery from doxorubicin-induced stress

Cancer cells can hijack cell cycles to exponentially increase their numbers, a process called proliferation. Cancer drugs can stop the growth of cancer cells by jumpstarting a complex chain of genetic and cellular events. But often, this story is more complex, involving treatments that don’t work as well as had been hoped.

How Do Cancer Cells Divide Despite Treatment?

Thyroid cancer stages range from 1 to 4 (sometimes referred to in Roman numerals as I, II, III, and IV). Stage 4 thyroid cancer is the most serious; stage 1 is the least severe. The stage of someone's cancer is determined by the size and spread of cancer cells from a tumor's primary site, in this case, the thyroid gland.

What Are the Stages of Thyroid Cancer?

A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models – all without showing signs of toxicity. Medulloblastoma is the most common malignant brain tumor in children. Survival rates vary according to which one of the four subtypes...

Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma

Melanoma is a type of skin cancer that can spread rapidly to other areas. However, there are also slow-growing types that may develop over many years. Melanoma is not as common as other types of skin cancer. However, unlike other skin cancers, melanoma has a high risk of spreading to other areas, which makes it the most dangerous type.

How fast does melanoma spread?

A second dendritic cell vaccine has received fast track designation from the Food and Drug Administration. The Food and Drug Administration (FDA) has granted a fast track designation to a dendritic cell vaccine for the treatment of patients with pancreatic ductal adenocarcinoma. Immuno-oncology company Diakonos Oncology Corporation announced the designation...

FDA Fast Tracks Pancreatic Cancer Vaccine

Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and previously presented at the 2024 ASCO Gastrointestinal Cancers Symposium (Abstract 603). Background.

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

Acute kidney injury (AKI) is one of the most frequent complications of cardiac surgery and the cause is complex. Renal hypoperfusion from decreased glomerular filtration rate after cardiopulmonary bypass is a major contributor. 1 This in combination with exogenous toxins, endogenous metabolites, oxidative stress, bleeding and reperfusion injury can all...

The PROTECTION Trial – A Randomized Trial of Intravenous Amino Acids for Kidney Protection

Massachusetts State

SurvivorNet

A 31-year-old Massachusetts man living with a cancerous brain tumor is taking back control of his life after once losing the ability to walk and do other everyday tasks. Rohan Venkatesh found hope in a new and innovative approach to brain cancer treatment that drastically cuts down the time it takes to get a diagnosis from ten days to just two.

New Dramatically Quicker Method For Brain Cancer Diagnosis Helps Save Massachusetts Man– His Remarkable Recovery

MILAN, Italy — In the ongoing battle against cancer, researchers are constantly seeking new weapons to add to our arsenal. Now, an intriguing approach is gaining traction: the fasting-mimicking diet (FMD). This dietary intervention, which mimics the effects of fasting while still allowing some food intake, is showing promise as a potential complement to traditional cancer treatments.

Fasting-mimicking diet: A promising ally in cancer treatment

In the last 6 months prior to PDAC diagnosis, visceral and subcutaneous adipose tissue decreased by 12.9% and 14.7%, respectively. LDL, total cholesterol and triglycerides also decreased before diagnosis. In the 36 months prior to diagnosis of pancreatic ductal adenocarcinoma, researchers observed “predominant changes” in patients’ body composition and biochemical...

Body fat, metabolic changes before pancreatic cancer diagnosis may aid in early detection

Surgery isn’t a typical treatment for multiple myeloma. But in some cases, surgery may be necessary to address complications from the disease. Multiple myeloma is a rare type of cancer that causes abnormal cells to develop in your bone marrow. As multiple myeloma spreads, it can lead to bone damage or loss.

The Role of Surgery in Treating Multiple Myeloma

Imagine tiny fists punching their way through your body. For some cancer patients, this may be the reality. Melanoma cells can mechanically tunnel their way through tissue using fleshy membrane protrusions without the need for chemicals that chew up the environment, researchers report June 12 in Developmental Cell. Cells have...

Some melanoma cancer cells may punch their way through the body

MadameNoire

The recent study emphasizes the urgent need for advanced technologies to treat and potentially cure breast cancer.

Double Mastectomy Treatment May Not Increase Cancer Survival Rate, New Study Reveals

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It’s crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties.

Light Can Control White Blood Cells’ Appetite for Cancer Cells

A team of researchers from Portugal and Belgium presented a paper highlighting the case of a patient with conjunctival CAM and offered an overview of the differential diagnosis and management of pigmented lesions of the conjunctiva. A team of researchers has conducted an investigation highlighting the case of a patient...

Researchers offer a case report, overview of the differential diagnosis of pigmented lesions of the conjunctiva

In part 1 of our interview with Anna Sureda, MD, PhD, president of the European Group for Blood and Marrow Transplantation, she summarized the current treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) and follicular lymphoma (FL). For our recent coverage of the European Hematology Association 2024 Congress,...

Advancements in R/R Lymphoma: Bispecific Antibodies in Focus

A complete blood count, chemistry profile, immunoglobulin test, and light chain assay are among the important blood tests doctors use to help diagnose multiple myeloma. Multiple myeloma is a type of cancer that affects the white blood cells that your bone marrow produces. Doctors can help diagnose multiple myeloma using...

How Do Blood Tests Help in Multiple Myeloma Diagnosis?

Thyroid lymphoma is an extremely rare but highly treatable cancer that affects the thyroid gland. It can cause a mass in the neck, difficulty swallowing, and shortness of breath. Most cases of thyroid cancer start when thyroid gland cells become cancerous. Thyroid lymphoma, meanwhile, is a disease that happens when...

What to Know About Thyroid Lymphoma

Merck and Johnson & Johnson have both acquired bispecific antibodies with applications in autoimmune and inflammatory conditions. Two recent pharmaceutical company acquisitions highlight the growing trend of research of bispecific antibodies beyond oncology, with one analyst projecting the bispecific antibodies market could reach $5.6 billion globally by 2035. There are...

Research of Bispecific Antibodies Beyond Cancer Gains Momentum

NewsBreak

Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine

Journal of Translational Medicine volume 22, Article number: 754 (2024) Cite this article. Organoids are approved by the US FDA as an alternative to animal experiments...

Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine

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