Columbus, OH

Genome Medicine volume 16, Article number: 101 (2024) Cite this article. The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mitigate the risk of severe fluoropyrimidine toxicity. However, this could not prevent all toxicities. The goal of this study was to identify additional genetic variants, both inside and outside DPYD, that may contribute to fluoropyrimidine toxicity.

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD

SurvivorNet

A rare form of endometrial cancer - uterine serous carcinoma – is more aggressive in Black women compared to white women, according to a new study published in the medical journal Proceedings of the National Academy of Sciences.

As Howard Stern’s Sidekick Robin Quivers, 71, Embraces ‘Bald Hairdo’ Amid Endometrial Cancer, New Study Finds a Rare Form of the Cancer Is More Aggressive In Black Women

Colorado State

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David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

shefinds

When it comes to maintaining optimal health, supplements can often be a great addition to your diet. However, it’s important to exercise caution; some supplements may pose significant risks. While supplements are often marketed as natural and beneficial, excessive or improper use can lead to serious health consequences. This is oftentimes especially true when it comes to the health of your liver and kidneys.

6 Unexpected Supplements That May Actually Be Leading To Kidney & Liver Damage, According To Experts: Green Tea Extract & More

Summary: New research reveals that glial cells, specifically oligodendrocytes, produce amyloid beta, a protein linked to Alzheimer’s disease, challenging the long-held belief that neurons are the sole contributors. This discovery opens new possibilities for therapies aimed at preventing plaque formation in the brain. Targeting both neurons and glial cells...

Glial Cells Play Key Role in Alzheimer’s Development

Autism spectrum disorder risk was similar with prenatal topiramate or lamotrigine vs. no antiseizure medication exposure. Prenatal valproate was tied to a dose-dependent increased autism spectrum disorder risk. Autism spectrum disorder incidence was higher for children with prenatal exposure to antiseizure medications vs. the general population, but some associations weakened...

Childhood autism may be linked to prenatal exposure to antiseizure medication

Could your personality influence your risk of developing Alzheimer’s disease? An analysis of UK Biobank data showed that individuals with amnestic mild cognitive impairment who also have high genetic risk for neuroticism are more likely to develop Alzheimer’s disease. Researchers used genetic data to calculate a neuroticism risk score and found that individuals with higher scores were more prone to developing Alzheimer’s. The paper was published in Human Brain Mapping.

Genetic risk for neuroticism increases the risk of Alzheimer’s disease

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

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J. Souza

According to cruise industry reports, the world's largest cruise ship is sailing well above 100% capacity, thanks to more beds being filled on recent sailings. Royal Caribbean’s newest flagship, the Icon of the Seas, is proving to be an unprecedented success, with occupancy rates far exceeding expectations.

The Largest Cruise Ship in the World is Sailing at 132% Capacity: How This is Even Possible

“The challenge now is to understand how these key aspects of mitochondrial metabolism become activated, why they stimulate metastasis, and whether we can safely block them,” says Ralph J. DeBerardinis, MD, PhD. Data recently published in the journal Nature indicate that renal cell carcinoma (RCC) tumors may rely on...

Mitochondrial metabolism may promote kidney cancer metastasis, new data show

Toxoplasma gondii is a parasitic protozoan that can infect pretty much all warm blooded animals. It is estimated that a third to half of the human population are infected with Toxoplasma – and many remain asymptomatic. However, it can lead to toxoplasmosis – which manifests as behavioural or neuropsychiatric changes in the animal (for example, Toxoplasma, a common parasite that makes you angry). It can also be passed on to fetuses, impacting their development or causing miscarriages. Whilst the parasites can infect most animals, it can only reproduce sexually inside feline hosts and the oocytes are shed in cat feces- this is why pregnant women are advised not to change cat litter trays.

Toxoplasma gondii – the good guy?

South Carolina State

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Explore Beaufort SC

The mantis shrimp is one tough customer. Beautiful and deadly are two words you don’t typically use to describe shrimp, but the mantis shrimp is definitely in a class of its own; earning a reputation as the ‘savage boxer of the sea’ and one of the most fearsome creatures in the ocean. And, they're right at home here in South Carolina.

Savage Boxer of the Sea: The Deadly Beauty of Mantis Shrimp

Researchers have discovered a new pathway used by cancer cells to infiltrate the brain and developed a promising therapy that targets this pathway with CAR T cells. Their study showed significant preclinical success in increasing survival and eradicating tumors in animal models of glioblastoma and other brain cancers. A team...

Brain Cancer Breakthrough: New Therapy Destroys Glioblastoma in Recently Unveiled Pathway

Hepatitis B virus (HBV) is associated with an increased risk of cervical cancer but not ovarian or endometrial cancers. Hepatitis B virus (HBV) is positively correlated with cervical cancer but not with ovarian or endometrial cancers, according to a study published in Discover Oncology.1. Gynecologic cancer is a growing health...

Hepatitis B Virus Associated With Cervical Cancer, Not Ovarian or Endometrial Cancers

Medications for Crohn's disease—a chronic, progressive, and relapsing inflammatory bowel disease (IBD)—include a variety of conventional and newer prescription therapies. These include drugs such as aminosalicylates, steroids, and antibiotics. Other novel treatments approved in recent years include biologics and immunosuppressants. All of these treatment options aim to decrease immune system activity to reduce inflammation.

Medications for Crohn’s Disease

A discovery regarding Mrc1 (Mediator of Replication Checkpoint 1)—a fission yeast protein involved in DNA replication—has been published in Cell. The discovery is the result of an international research collaboration, led by Professors Genevieve Thon and Anja Groth at the University of Copenhagen. Dr. Sebastian Charlton, shared first...

International team discovers key protein that helps cells maintain their identity

Devra Lee

Disclaimer: This content was written by Devra Lee for general informational and entertainment purposes only. This service is to provide astrological information that has been researched, recorded, and observed by the author.

Horoscope of the Day, Friday, August 16th

Atsena announced initial positive data from the LIGHTHOUSE study of ATSN-201 in May 2024. The FDA has granted Rare Pediatric Disease Designation (RPDD) to Atsena Therapeutics’ ATSN-201 gene therapy for the potential treatment of X-linked retinoschisis (XLRS).1. “We are pleased to receive the FDA’s RPDD for ATSN-201, which also...

XLRS Gene Therapy Gets RPDD Designation

New Jersey State

Collingswood, NJ

Morristown Minute

CAMDEN, N.J. – Ralston Boswell, 34, of Collingswood, New Jersey, has admitted to participating in schemes to fraudulently obtain Paycheck Protection Program (PPP) loans and unemployment insurance benefits. The announcement was made by U.S. Attorney Philip R. Sellinger.

Plea: Man's PPP & Unemployment Fraud - $209K Scam

David Suhy, PhD, the cofounder and chief scientific officer at Earli, discussed the company’s unique approach to cancer diagnosis. Thus far, DNA vectors have largely been thought of as tools for directly treating disease in the form of gene therapy or cell therapy. Other useful applications may be possible, however.

Using DNA Nanoplasmids as a Diagnostic Tool in Cancer

Thrombocytopenia is an atypically low platelet count. Acquired thrombocytopenia is caused by conditions that develop throughout your life instead of genes inherited from birth. Acquired thrombocytopenia can develop for many different reasons, such as:. thrombotic thrombocytopenic purpura, which is a medical emergency that can lead to serious internal bleeding. People...

Overview of Acquired Thrombocytopenia

NewsBreak

GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics

Journal of Translational Medicine volume 22, Article number: 767 (2024) Cite this article. Genetic epilepsy with febrile seizures plus (GEFS+) is a genetic epilepsy syndrome characterized...

GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics

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