Columbus, OH

Journal of Translational Medicine volume 22, Article number: 768 (2024) Cite this article. Postoperative liver metastasis significantly impacts the prognosis of pancreatic neuroendocrine tumor (panNET) patients after R0 resection. Combining computational pathology and deep learning radiomics can enhance the detection of postoperative liver metastasis in panNET patients. Methods. Clinical data,...

A novel model for predicting postoperative liver metastasis in R0 resected pancreatic neuroendocrine tumors: integrating computational pathology and deep learning-radiomics

Journal of Translational Medicine volume 22, Article number: 771 (2024) Cite this article. Stroke is a globally dangerous disease capable of causing irreversible neuronal damage with limited therapeutic options. Meldonium, an inhibitor of carnitine-dependent metabolism, is considered an anti-ischemic drug. However, the mechanisms through which meldonium improves ischemic injury and its potential to protect neurons remain largely unknown.

Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury

Ohio State

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The Lantern

On Tuesday, licensed Ohio dispensaries began legally selling non-medical marijuana to consumers; however, the drug’s possession, growth and/or usage are still prohibited on Ohio State’s campus. Credit: Jefferee Woo/Tampa Bay Times/TNS [Original caption: Four citizen-led petitions with proposals to update Dallas’ charter hit the 20,000 valid signature threshold to make it on the Nov. 5 election ballot, including one that would ban police officers from arresting or citing people carrying less than four ounces of marijuana.] As of Tuesday, students 21 and older can now legally purchase marijuana in Ohio.

Dispensary sales of recreational marijuana began Tuesday; possession and usage still prohibited on Ohio State’s campus

Las Vegas, NV

Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Maitland, FL

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Akeena

If you’re a fan of hearty Italian meals without the hassle of cooking, you might be feeling a bit nostalgic. Buca di Beppo, the Orlando-based chain known for its family-style Italian feasts, is closing its doors—not just one, but 14 locations!

A Much-Loved Italian Restaurant in Florida Has Closed, and the Company Will Also Close 13 More

Avidity Biosciences‘ delpacibart zotadirsen, or del-zota for short — formerly called AOC 1044 — was found to safely increase levels of dystrophin production to 25% of normal in people with Duchenne muscular dystrophy (DMD), according to new data from the EXPLORE44 trial. In the Phase 1/2 clinical...

Del-zota increases dystrophin in DMD patients, new trial data show

Saint Petersburg, FL

Hey foodies and diner lovers! It looks like the beloved Metro Diner in St. Petersburg, known for its hearty portions and Guy Fieri's endorsement, has hit a bump in the road. This popular spot, famous for its pancakes, fried chicken and waffles, and mouthwatering meatloaf, has had to temporarily shut its doors due to some serious issues flagged by a recent state inspection.

Green mold, live roaches and live flying insects - Popular diner closed down in Florida

Colorado State

David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

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NewsNinja

A lady is cautioning others about purchasing budget earrings from Amazon, Shein, and H&M, after she experienced keloid formations on her earlobes due to wearing them. On a TikTok post that has garnered more than 334,000 likes, Sailor Rozema (@sailor.rozema), a content creator, shares a warning with her community of "dangly earring girls": the inexpensive jewelry found in fast fashion can have negative impacts on your well-being.

‘I’ll never be wearing earrings for the rest of my life’: Customer warns against buying from Shein

Jacksonville, FL

Jacksonville Today

A permanent marker will be erected to honor the victims of the racist mass shooting nearly a year ago at a Dollar General store in the New Town community. City Council approved the marker 17-0 on Tuesday night.

Marker will honor victims of racist Dollar General shooting

Research on over 24,000 men revealed that low testosterone levels significantly increase the risks of death from all causes and cardiovascular issues, underlining the hormone’s impact on aging men’s health. A systematic review and meta-analysis revealed that men with low baseline levels of endogenous serum testosterone face a...

Low Testosterone in Men Linked to Increased Risk for Death

South Carolina State

Colleton County, SC

Explore Beaufort SC

Some beachgoers were in for a surprise this week when a bizarre looking prehistoric fish washed ashore in Colleton County along Edisto Beach at Edisto Beach State Park. It turned out to be an atlantic sturgeon.

Rare Atlantic sturgeon washes ashore on South Carolina beach

Kentucky State

Northern Kentucky Tribune

Major changes to how real estate transactions are conducted are set to take affect this month that will effect how both sellers, and buyers, compensate their agents. On March 15, the National Association of Realtors (NAR) settled a lawsuit brought by home sellers regarding how broker commissions were handled. As a result of that settlement, the NAR will remove agent compensation amounts from Multiple Listing Services, provide detailed compensation information to buyers and sellers and attain a written agreement outlining that compensation structure.

Broker commissions on real estate transactions will look a lot different starting August 17

Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and previously presented at the 2024 ASCO Gastrointestinal Cancers Symposium (Abstract 603). Background.

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

New research indicates that more efficient treatment methods are available for patients undergoing CAR-T cell therapy, suggesting that current FDA guidelines mandating that patients remain close to treatment centers for four weeks after receiving the therapy results in unnecessary challenges and additional medical costs. According to the findings, extending close...

CAR-T Cell Therapy Cancer Risks May Drop Off After Two Weeks of Therapy: Study

Enrollment will soon begin for the dose-expansion portion of the ongoing phase 1 trial assessing EO-3021 in CLDN18.2-positive tumors. Treatment with EO-3021 (SYSA1801) produced promising preliminary data in a small cohort of patients with advanced, unresectable, or metastatic gastric or gastroesophageal junction (GEJ) cancers expressing Claudin 18.2 (CLDN18.2), according to dose-escalation findings from a phase 1 trial (NCT05980416).1.

EO-3021 Elicits Responses in Advanced CLDN18.2+ Gastric/GEJ Cancer

Kansas State

Missouri State

CJ Coombs

National Center for Missing and Exploited Children (NCMEC) helps to locate missing children. Since July 1, 2024, according to the National Center for Missing and Exploited Children (NCMEC), 174 children have been reported missing in the U.S. Since January 1, 2024, there was a total of 1,445 reported missing in the country.

Missing Missouri children as of July 17, 2024, according to the NCMEC

Georgia State

Daily Coffee Press

The chances for the tropical wave in the Atlantic developing have now risen to 80% over the next seven days. The National Hurricane Center (NHC) has advised that this disturbance could become the next tropical storm or hurricane within the coming days, potentially targeting the U.S. East Coast.

Tropical Wave That Could Impact Georgia Now Has 80% Chance of Development

Denver, CO

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

A new study found that older patients with atrial functional mitral regurgitation who underwent mitral valve surgery had significantly better outcomes than those who received medical management alone, including lower rates of heart failure hospitalization and death. Patients with atrial functional mitral regurgitation (AFMR) who undergo mitral valve (MV) surgery...

Surgery Improves Outcomes for Patients With Atrial Functional Mitral Regurgitation

NewsBreak

Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I

Journal of Translational Medicine volume 22, Article number: 769 (2024) Cite this article. Although immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only...

Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I

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