Journal of Translational Medicine volume 22, Article number: 769 (2024) Cite this article. Although immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only a minority of colorectal cancer (CRC) patients respond to them. Enhancing tumor immunogenicity by increasing major histocompatibility complex I (MHC-I) surface expression is a promising strategy to boost the antitumor efficacy of ICIs.

Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I

BMC Public Health volume 24, Article number: 2225 (2024) Cite this article. Parkinson’s disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship between renal function and the risk of PD remains poorly understood. This study aims to explore the association between kidney function and the risk of developing PD.

Association between kidney function and Parkinson’s disease risk: a prospective study from the UK Biobank

Early-in-life exposure to a common toxic chemical found in some foods and in breastmilk may disrupt healthy bacteria in the gut and increase a person’s risk for developing various diseases later in life, according to a new animal study. The findings, published Aug. 14 in the journal Environmental Health...

Early exposure to toxic TCDF messes with gut bacteria later in life, finds study in mice

Although the overall use of benzodiazepines does not appear to increase the risk of dementia, long-term use is associated with a reduction in the volume of critical brain areas, such as the hippocampus and the amygdala, according to new research published in BMC Medicine. This finding supports current medical guidelines that caution against prolonged benzodiazepine use.

Long-term benzodiazepine use linked to shrinkage in two brain regions

Inflammation is a crucial component of our health. It springs into action when needed to fight off foreign invaders such as bacteria and viruses…then calms down and waits for the next danger. But for billions of people, chronic stress, the Standard American Diet (SAD, a fitting acronym) and environmental insults including smoking and pollution have triggered inflammation to turn on…and stay on. The result—chronic inflammation—is like an out-of-control campfire that’s jumped beyond the pit, setting every organ it touches aflame and increasing the odds of developing cancer, heart disease, dementia, diabetes, autoimmune disease and more.

How to Reduce Chronic Inflammation

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

community_voice

NewsNinja

A lady is cautioning others about purchasing budget earrings from Amazon, Shein, and H&M, after she experienced keloid formations on her earlobes due to wearing them. On a TikTok post that has garnered more than 334,000 likes, Sailor Rozema (@sailor.rozema), a content creator, shares a warning with her community of "dangly earring girls": the inexpensive jewelry found in fast fashion can have negative impacts on your well-being.

‘I’ll never be wearing earrings for the rest of my life’: Customer warns against buying from Shein

Deseret News

Researchers say there are health benefits associated with one to two bowel movements a day, which they deem the "Goldilocks zone."

Does your poop tell a story of your health?

Colorado State

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

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David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Las Vegas, NV

Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Pompano Beach, FL

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

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Akeena

In a shocking revelation, Kings Mart, a grocery store in Pompano Beach, has been slapped with a series of severe health violations by the Florida Department of Agriculture. The inspection, carried out by Francis Odio, uncovered a disturbing range of problems that have led to the immediate closure of several sections of the store.

An inspection found bugs in the food and rodent poop on the shelves at a Florida grocery store

Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson‘s Disease. The findings also support less studied pathways involved in the pathogenesis of the disease. The study, published...

deCODE genetics: Rare sequence variants, that associate with a high risk of Parkinson‘s Disease

shefinds

Supplements are often taken to improve health and fill nutritional gaps, but not all are as beneficial as they seem. Some supplements, particularly when taken in excess or without proper guidance, can have unintended negative effects. For example, certain supplements can unknowingly contribute to high blood pressure and increase the risk of cardiovascular events.

4 Worst Supplements That Could Actually Lead To High Blood Pressure And Cardiovascular Events: Licorice Root & More

J. Souza

According to cruise industry reports, the world's largest cruise ship is sailing well above 100% capacity, thanks to more beds being filled on recent sailings. Royal Caribbean’s newest flagship, the Icon of the Seas, is proving to be an unprecedented success, with occupancy rates far exceeding expectations.

The Largest Cruise Ship in the World is Sailing at 132% Capacity: How This is Even Possible

Denver, CO

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

An anti-inflammatory diet reduced the risk of dementia by 31% in people even if they had type 2 diabetes, heart disease or stroke, according to a new study.

Eating these foods lowers dementia risk, even with type 2 diabetes and heart disease, study says

Research on over 24,000 men revealed that low testosterone levels significantly increase the risks of death from all causes and cardiovascular issues, underlining the hormone’s impact on aging men’s health. A systematic review and meta-analysis revealed that men with low baseline levels of endogenous serum testosterone face a...

Low Testosterone in Men Linked to Increased Risk for Death

Cooking With Maryann

This recipe is sooo tasty! It truly is for garlic lovers! It involves sautéing onions and mushrooms in butter and oil until golden, then adding wine to reduce. Garlic, thyme, and parsley are stirred in for flavor, followed by seasoning with salt and pepper. The dish is garnished with additional parsley and served warm, making for a savory, aromatic side. Here's what you'll need to make it:

Garlic Mushrooms in Brown Butter Herb Sauce

Kansas State

Missouri State

CJ Coombs

National Center for Missing and Exploited Children (NCMEC) helps to locate missing children. Since July 1, 2024, according to the National Center for Missing and Exploited Children (NCMEC), 174 children have been reported missing in the U.S. Since January 1, 2024, there was a total of 1,445 reported missing in the country.

Missing Missouri children as of July 17, 2024, according to the NCMEC

Ohio State

The Lantern

On Tuesday, licensed Ohio dispensaries began legally selling non-medical marijuana to consumers; however, the drug’s possession, growth and/or usage are still prohibited on Ohio State’s campus. Credit: Jefferee Woo/Tampa Bay Times/TNS [Original caption: Four citizen-led petitions with proposals to update Dallas’ charter hit the 20,000 valid signature threshold to make it on the Nov. 5 election ballot, including one that would ban police officers from arresting or citing people carrying less than four ounces of marijuana.] As of Tuesday, students 21 and older can now legally purchase marijuana in Ohio.

Dispensary sales of recreational marijuana began Tuesday; possession and usage still prohibited on Ohio State’s campus

I grew up on these babies. This cookie is sweet nostalgia to me. There are so many variations to make it too, you really can't go wrong with it! For a super easy and fast cookie bar, these are a winner!

Magic Layer Bars aka Hello Dolly Bars

NewsBreak

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Cardiovascular Diabetology volume 23, Article number: 299 (2024) Cite this article. Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome,...

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

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