Columbus, OH

The FDA has approved neoadjuvant durvalumab plus chemotherapy, followed by adjuvant durvalumab, for select resectable non–small cell lung cancer. The FDA has approved durvalumab (Imfinzi) in combination with platinum-containing chemotherapy as neoadjuvant treatment, followed by single-agent durvalumab as adjuvant treatment after surgery, for adult patients with resectable (tumors ≥4 cm and/or node positive) non–small cell lung cancer and no known EGFR mutations or ALK rearrangements.1.

FDA Approves Perioperative Durvalumab Plus Chemotherapy in Resectable NSCLC

In this episode of Targeted Talks, Edwin Choy, MD, PhD, discussed the FDA approval of afamitresgene autoleucel for the treatment of patients with advanced synovial sarcoma. In this episode of Targeted Talks, Edwin Choy, MD, PhD, director of the sarcoma program at the Division of Hematology Oncology at Massachusetts General Hospital, a founding member of Mass General Brigham, and associate professor of medicine at Harvard Medical School, delves into the recent approval of afamitresgene autoleucel (afami-cel; Tecelra) for the treatment of patients with advanced synovial sarcoma.

Breaking New Ground in Synovial Sarcoma: Choy on the FDA Approval of Afami-cel

A multicenter, randomized, double-blind, placebo-controlled trial done performed in the the United Kingdom June 2014 to October 2017), enrolled 207 adult patients with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months, after an inadequate response to analgesic medications.

Pain Reduction with Methotrexate in Knee Osteoarthritis

Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and previously presented at the 2024 ASCO Gastrointestinal Cancers Symposium (Abstract 603). Background.

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

Patients with NSCLC taking five or more medications tended to have worse survival, highlighting the need for medication management, research showed. Older patients with advanced non-small cell lung cancer (NSCLC) receiving immunotherapy treatment tended to have worse survival outcomes if they were taking five or more other oral or inhaled medications, according to a study published in the Journal of Geriatric Oncology.

Polypharmacy May Shorten Survival in Lung Cancer

Ventricular resection is a type of open-heart surgery to reshape and resize the heart. The surgery may help to improve survival in people with heart failure. Ventricular resection is a surgical procedure to treat heart failure in people with an enlarged heart. The surgery reshapes the heart and returns it to a standard size.

What is the ventricular resection survival rate?

Regina Barragan-Carrillo, MD, discusses a pilot study evaluating the use of camu camu in combination with ipilimumab and nivolumab for treating metastatic renal cell carcinoma. Regina Barragan-Carrillo, MD, medical oncologist, postdoctoral fellow, Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, discusses a pilot study evaluating...

Evaluating Camu Camu With Ipilimumab and Nivolumab in mRCC

SurvivorNet

Billiards icon Jeanette Lee, 53, who was diagnosed with advanced stage ovarian cancer in 2021 and suffered a heart attack earlier this year, has offered fans a health update, revealing she has started cardio rehabilitation and is "fighting a good fight" while battling chronic pain and weakness after undergoing chemotherapy for three years.

‘Black Widow’ Billiards Legend Jeannette Lee, 53, Starts Rehab After Surviving Heart Attack Amid Ovarian Cancer Treatment & Chronic Pain

Las Vegas, NV

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Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Patients with locally advanced muscle-invasive bladder cancer may benefit from dose-dense gemcitabine and cisplatin. The treatment of preoperative dose-dense gemcitabine and cisplatin chemotherapies was well-tolerated and effective in patients with locally advanced muscle-invasive bladder cancer; however, more research is needed, an expert told CURE®. “The dose-dense part means to...

Dose-Dense Chemo for Muscle-Invasive Bladder Cancer May Be Feasible

Non smoker diagnosed Wirth lung cancer and EGFR medications used

Dismissed By Doctors, Distance Runner Mom, 43, Diagnosed With Lung Cancer– She Never Smoked

A complete blood count, chemistry profile, immunoglobulin test, and light chain assay are among the important blood tests doctors use to help diagnose multiple myeloma. Multiple myeloma is a type of cancer that affects the white blood cells that your bone marrow produces. Doctors can help diagnose multiple myeloma using...

How Do Blood Tests Help in Multiple Myeloma Diagnosis?

Neoadjuvant/adjuvant sacituzumab govitecan showed encouraging intratumoral concentrations in patients with brain metastases as well as glioblastoma. The antibody-drug conjugate (ADC), sacituzumab govitecan (Trodelvy), given in the neoadjuvant and adjuvant settings, displayed promising preliminary activity in patients undergoing craniotomy for breast cancer with brain metastases or those with recurrent glioblastoma (GBM), according to a phase 0 window-of-opportunity study (NCT03995706) published in Nature Communications.

Sacituzumab Govitecan Shows Preliminary Activity in Patients With Brain Mets, GBM

Surgery isn’t a typical treatment for multiple myeloma. But in some cases, surgery may be necessary to address complications from the disease. Multiple myeloma is a rare type of cancer that causes abnormal cells to develop in your bone marrow. As multiple myeloma spreads, it can lead to bone damage or loss.

The Role of Surgery in Treating Multiple Myeloma

Patient recruitment for the phase 2 trial is expected to begin by the end of 2024. The US Department of Defense has awarded a $3.6 million grant to advance a phase 2 trial (NCT06493370) of high-dose intravenous ascorbate (vitamin C) plus chemotherapy (gemcitabine/carboplatin) in patients with muscle-invasive bladder cancer (MIBC), the University of Kansas Cancer Center announced in a news release.1.

Grant to fund trial of intravenous ascorbate plus chemotherapy for MIBC

Imfinzi may be used alone, or with chemotherapy in tandem with the other approved treatment, Lynparza. Imfinzi (durvalumab) and Lynparza (olaparib), two AstraZeneca products, have been approved as treatments for certain people who have primary advanced or recurrent endometrial cancer throughout the European Union (EU), AstraZeneca said in a press release on Aug. 14, 2024 (1). The European Commission’s approval follows a positive opinion by the Committee for Medicinal Products for Human Use based on a subgroup analysis of mismatch repair (MMR) status in a Phase III trial (DUO-E), the results of which were published in the Journal of Clinical Oncology (2).

Two AstraZeneca Treatments for Endometrial Cancer Approved in EU

A phase 1b study will investigate PTM-01, a directed administration of paclitaxel, in patients with nonmetastatic pancreatic cancer. The FDA has granted clearance to the investigational new drug (IND) application of PTM-01. A phase 1b study of PTM-01 in pancreatic ductal adenocarcinoma (PDAC) will proceed. PTM-01 is a proprietary flexible...

FDA Clears IND Application of Novel Paclitaxel Administration in Pancreatic Cancer

Transitional cell carcinoma (TCC) kidney cancer is a rare type of cancer that may have no symptoms at first. A person may be more at risk due to several factors, including exposure to certain substances. Transitional cell carcinoma (TCC) kidney cancer is a type of cancer in the lining of...

What to know about TCC kidney cancer

In a study reported in JAMA Otolaryngology–Head & Neck Surgery, Gallagher et al found that individuals with cannabis-related disorder were at an increased risk of head and neck cancer vs those without cannabis-related disorder. Cannabis-related disorders are defined by the excessive use of cannabis with associated psychosocial symptoms. Study...

Cannabis Use and Risk of Head and Neck Cancer

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Cooking With Maryann

This recipe is sooo tasty! It truly is for garlic lovers! It involves sautéing onions and mushrooms in butter and oil until golden, then adding wine to reduce. Garlic, thyme, and parsley are stirred in for flavor, followed by seasoning with salt and pepper. The dish is garnished with additional parsley and served warm, making for a savory, aromatic side. Here's what you'll need to make it:

Garlic Mushrooms in Brown Butter Herb Sauce

NewsBreak

Blinatumomab Improves 3-Year Survival in B-ALL vs Chemotherapy

Findings from the phase 3 E1910 study showed that blinatumomab extended overall survival when added to chemotherapy vs chemotherapy alone in B-cell precursor acute lymphoblastic leukemia....

Blinatumomab Improves 3-Year Survival in B-ALL vs Chemotherapy

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