Parasites take an enormous toll on human and veterinary health. But researchers may have found a way for patients with brain disorders and a common brain parasite to become frenemies. A new study published in Nature Microbiology has pioneered the use of a single-celled parasite, Toxoplasma gondii, to inject therapeutic...

A common parasite could deliver drugs to the brain—how scientists are turning Toxoplasma gondii from foe into friend

A parasite that is most widely known for its existence in cat feces could be a delivery system for proteins that target neurological disorders, a new study has found. Researchers successfully targeted protein dispersal by using an engineered version of Toxoplasma gondii, a parasite in cat feces and undercooked meat that is largely harmless to humans.

Researchers engineer cat poop parasite to deliver therapeutic drugs to the brain

Turmeric, renowned for its vibrant yellow hue and extensive use in culinary traditions, contains curcumin, a compound known for its potent health benefits. However, turmeric itself, beyond just curcumin, has been studied for a variety of therapeutic properties. Recent research, including findings from the Therapeutic Goods Administration (TGA) in Australia, eMedicineHealth, and Infobae, provides a comprehensive overview of both the potential benefits and risks associated with turmeric, particularly concerning liver and kidney health.

Turmeric’s Surprising Effects: What It Could Do to Your Liver and Kidneys

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When it comes to maintaining optimal health, supplements can often be a great addition to your diet. However, it’s important to exercise caution; some supplements may pose significant risks. While supplements are often marketed as natural and beneficial, excessive or improper use can lead to serious health consequences. This is oftentimes especially true when it comes to the health of your liver and kidneys.

6 Unexpected Supplements That May Actually Be Leading To Kidney & Liver Damage, According To Experts: Green Tea Extract & More

Deseret News

Researchers say there are health benefits associated with one to two bowel movements a day, which they deem the "Goldilocks zone."

Does your poop tell a story of your health?

Early-in-life exposure to a common toxic chemical found in some foods and in breastmilk may disrupt healthy bacteria in the gut and increase a person’s risk for developing various diseases later in life, according to a new animal study. The findings, published Aug. 14 in the journal Environmental Health...

Early exposure to toxic TCDF messes with gut bacteria later in life, finds study in mice

Colorado State

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David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Antiretroviral therapy (ART) has been a game-changer for people with HIV. But HIV is skilled at “hiding” and can reappear in the blood stream shortly after ART is stopped. That’s why NIAID and partners are investigating strategies to completely clear HIV from a person’s body, effectively curing them, or to reduce it to levels that can be suppressed by their own immune systems.

Broadly Neutralizing Antibodies Evaluated in Many HIV Cure Strategies

Strokes are caused by limited blood flow to the brain. Described as a cardiovascular disease, strokes result from a clogged or blocked blood vessel that leads to a lack of oxygen. Around 800,000 individuals have a stroke each year in the United States. The most common type of stroke is referred to as ischemic, which occurs when blood is occluded from a clot or narrow blood vessel. If the brain has low blood exposure, it limits the oxygen and nutrients the brain needs. As a result, brain cells begin to die, and a stroke occurs.

Strokes Have a Lasting Effect on Immune Cells

Health

Medically reviewed by Brigid Dwyer, MDMedically reviewed by Brigid Dwyer, MDDementia is a broad term that describes the loss of cognitive abilities like thinking, remembering, using language, and making decisions. Lewy body dementia (LBD) is one type of dementia, named after the scientist who discovered this variation. This type of dementia is thought to be caused by a buildup of a specific protein in the brain.  There are two types of LBD: dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). In general, both types of LBD are caused by the same accumulation of protein in the brain and...

Signs and Symptoms of Lewy Body Dementia

C. diff infection can cause diarrhea. While it may lead your poop to change color, there are no specific colors that are definitive evidence of having C. diff. According to the Centers for Disease Control and Prevention (CDC), Clostridioides difficile (C. diff) accounts for. 15% to 25%. of all cases...

What to Know About Yellow C. diff Diarrhea

Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson‘s Disease. The findings also support less studied pathways involved in the pathogenesis of the disease. The study, published...

deCODE genetics: Rare sequence variants, that associate with a high risk of Parkinson‘s Disease

Journal of Translational Medicine volume 22, Article number: 768 (2024) Cite this article. Postoperative liver metastasis significantly impacts the prognosis of pancreatic neuroendocrine tumor (panNET) patients after R0 resection. Combining computational pathology and deep learning radiomics can enhance the detection of postoperative liver metastasis in panNET patients. Methods. Clinical data,...

A novel model for predicting postoperative liver metastasis in R0 resected pancreatic neuroendocrine tumors: integrating computational pathology and deep learning-radiomics

Denver, CO

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

Muscle diseases can be mysterious and challenging to understand. These conditions affect the muscles, causing weakness, pain, and sometimes even disability. But what exactly are muscle diseases? Muscle diseases are disorders that impair the function of muscles, making everyday tasks difficult. They can be genetic, like muscular dystrophy, or acquired, such as myositis. Some muscle diseases are rare, while others are more common. They can affect anyone, regardless of age or gender. Understanding these conditions is crucial for managing symptoms and improving quality of life. In this post, we’ll explore 30 fascinating facts about muscle diseases to help you better understand these complex conditions.

30 Facts About Muscle Diseases

For decades, sodium restriction has been a cornerstone in the management of heart failure, driven by the belief that reducing salt intake helps control fluid retention and improve outcomes. Heart failure is marked by the activation of the renin-angiotensin and noradrenergic systems, leading to fluid retention. Consequently, limiting sodium intake has been seen as a way to mitigate these effects and reduce edema and other complications associated with heart failure.

Salt restriction in heart failure

Medications for Crohn's disease—a chronic, progressive, and relapsing inflammatory bowel disease (IBD)—include a variety of conventional and newer prescription therapies. These include drugs such as aminosalicylates, steroids, and antibiotics. Other novel treatments approved in recent years include biologics and immunosuppressants. All of these treatment options aim to decrease immune system activity to reduce inflammation.

Medications for Crohn’s Disease

Cardiovascular Diabetology volume 23, Article number: 299 (2024) Cite this article. Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precursor trimethylamine (TMA) is synthesized by the intestinal microbiome, crosses the intestinal barrier and is metabolized to TMAO by hepatic flavin-containing monooxygenases (FMO). The intricate interactions of microbiome alterations and TMAO in relation to HFpEF manifestation and progression are analyzed here.

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Journal of Translational Medicine volume 22, Article number: 767 (2024) Cite this article. Genetic epilepsy with febrile seizures plus (GEFS+) is a genetic epilepsy syndrome characterized by a marked hereditary tendency inherited as an autosomal dominant trait. Patients with GEFS+ may develop typical febrile seizures (FS), while generalized tonic–clonic seizures (GTCSs) with fever commonly occur between 3 months and 6 years of age, which is generally followed by febrile seizure plus (FS+), with or without absence seizures, focal seizures, or GTCSs. GEFS+ exhibits significant genetic heterogeneity, with polymerase chain reaction, exon sequencing, and single nucleotide polymorphism analyses all showing that the occurrence of GEFS+ is mainly related to mutations in the gamma-aminobutyric acid type A receptor gamma 2 subunit (GABRG2) gene. The most common mutations in GABRG2 are separated in large autosomal dominant families, but their pathogenesis remains unclear. The predominant types of GABRG2 mutations include missense (c.983A → T, c.245G → A, p.Met199Val), nonsense (R136*, Q390*, W429*), frameshift (c.1329delC, p.Val462fs*33, p.Pro59fs*12), point (P83S), and splice site (IVS6+2T → G) mutations. All of these mutations types can reduce the function of ion channels on the cell membrane; however, the degree and mechanism underlying these dysfunctions are different and could be linked to the main mechanism of epilepsy. The γ2 subunit plays a special role in receptor trafficking and is closely related to its structural specificity. This review focused on investigating the relationship between GEFS+ and GABRG2 mutation types in recent years, discussing novel aspects deemed to be great significance for clinically accurate diagnosis, anti-epileptic treatment strategies, and new drug development.

GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics

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Total Apex Sports & Entertainment

In the world of astrology, certain dates align with celestial energies that lean toward the fruition of dreams. Today is one such day. The energy brings with it an essence of positivity, offering a powerful blend of heavenly influences that can bring longings into existence. For three zodiac signs in particular, this is especially true. Aries, Leo, and Sagittarius, the stars are aligning in your favor more so than the rest of us. Here's how these signs can take advantage of this powerful energy and make their dreams begin to come true.

3 Zodiac Signs Whose Dreams Come True | August 16, 2024

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Toxoplasma gondii – the good guy?

Toxoplasma gondii is a parasitic protozoan that can infect pretty much all warm blooded animals. It is estimated that a third to half of the human...

Toxoplasma gondii – the good guy?

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