Solly Chedid, MD, shares insights on optimizing anemia management in patients with lower-risk MDS and outlines remaining unmet needs in treating anemia. Case: Frontline Use of Erythroid Maturating Agent (EMA): Luspatercept. Clinical Presentation:. 70-year-old man diagnosed 6 months ago with LR-MDS with multilineage dysplasia - moderate anemia (Hb 11.2) and...

Key Takeaways and Unmet Needs in Lower-Risk MDS Anemia Management

Investigators previously assessed treatment with opaganib in patients with advanced cholangiocarcinoma and prostate cancer. The FDA has granted orphan drug designation to opaganib (ABC294640), an investigational SPHK2 selective inhibitor, as a treatment for pediatric patients with neuroblastoma, according to a press release from the developer, RedHill Biopharma Ltd.1. Investigators hypothesize...

Opaganib Earns FDA Orphan Drug Status in Neuroblastoma

T-DXd receives FDA breakthrough therapy designation for HR+/HER2-low breast cancer and real-world data confirms brexu-cel’s efficacy in relapsed/refractory B-cell ALL. A New AI-based study enrolls first patient, strengths and weakness in multiple myeloma treatment are examined, and tafasitamab combination scores in FL. Want to test your knowledge on the...

The Targeted Pulse: T-Dxd Received FDA Breakthrough Therapy Designation, Real-World Data Confirms Brexu-cel’s Impact, and More

Salt Lake City, UT

The drop improves vision by breaking up degraded protein complexes that cause lens clouding. Randall Olson, MD, corresponding author of the study, Moran Eye Center CEO and Distinguished Professor and Chair of the Department of Ophthalmology and Visual Sciences at the University of Utah, Salt Lake City, and colleagues reported that a novel eye drop (C-KAD, Livionex Inc.) has been formulated to treat early to moderate age-related cataracts. The drop improves vision by breaking up degraded protein complexes that cause lens clouding, which leads to cataracts and vision loss, when instilled in the eye.

Efficacy of novel eye drop to reverse cataracts after phase 1/2 study

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

community_voice

NewsNinja

An Aldi shopper recently shared her disturbing experience with a moldy rice package from the supermarket, sparking debate. A TikTok user named @defonotlils posted a video on June 6 that quickly became popular, accumulating more than 674,600 views. In the video, she shares what happened after finding out about something.

This is why I don’t shop at Aldi: Woman can’t believe what she found in her packaged rice from Aldi

Health

Medically reviewed by Jay N. Yepuri, MDMedically reviewed by Jay N. Yepuri, MDLiver function blood tests are tests that detect how well your liver is working. Your liver is an important organ that performs key roles, such as metabolizing fats and proteins, removing toxins from your blood, synthesizing proteins, and regulating red blood cells.Liver function tests (LFTs) can also measure the levels of different liver enzymes, proteins, and bilirubin in the blood. High or low levels of these substances may be a sign that your liver isn't functioning as properly as it should.Liver function tests are also helpful because they...

What To Expect During a Liver Function Blood Test

The MACI Arthro can be administered through small incisions using custom instruments to repair cartilage defects in the knee. The FDA has approved Vericel Corporation’s MACI for repairing cartilage defects in the knee. According to the company, MACI uses a patient’s own cells cultured on a porcine collagen membrane. This method, also known as MACI Arthro, can be administered through small incisions using custom instruments, providing a substantial improvement in full-thickness cartilage defects up to 4 cm² in size, offering a less invasive option, according to the company.1.

FDA Approves Arthroscopic Delivery of Vericel’s MACI for Knee Cartilage Defects

The following is a summary of “Kidney volume and risk of incident kidney outcomes,” published in the June 2024 issue of Nephrology by Wu et al. Low total kidney volume (TKV) increases the risk of chronic kidney disease (CKD). Researchers conducted a prospective study investigating the nonlinear relationships,...

Lower Kidney Volume Linked to Increased Risk of Incident CKD

Acute kidney injury, when the kidneys suddenly stop working properly, impacts many with diabetes. Here’s what to know about the condition, which is usually reversible. Acute kidney injury (AKI) is a sudden decline in kidney function. The condition is different from chronic kidney disease (CKD), but occurs more frequently...

Acute Kidney Injury: Causes, Treatment, and Prevention

The Lens

This year’s area of low oxygen in the Gulf of Mexico is larger than average, the National Oceanic and Atmospheric Administration (NOAA) announced on Thursday. The “dead zone” is approximately 6,705 square miles , as measured last week. Within NOAA’s 38 years of measuring the dead zone, this year’s assessment marks the 12th-largest area of low to no oxygen, which can kill fish and marine life.

Gulf ‘dead zone’ larger than average, larger than expected for 2024, scientists announce

The following is a summary of “Impulsivity and inhibitory control in deficit and non-deficit schizophrenia,” published in the June 2024 issue of Psychiatry by Bielecki et al. The relationship between impulsivity and inhibitory control in schizophrenia is subject to conflicting evidence, reflecting ongoing debates and varied findings across...

Understanding Impulsivity and Inhibition Across Schizophrenia Subgroups

WEDNESDAY, July 31, 2024 (HealthDay News) — For patients with knee osteoarthritis (KOA), methotrexate added to usual medication is associated with a significant reduction in pain and improvement in stiffness and function at six months, according to a study published online July 30 in the Annals of Internal Medicine.

Methotrexate Beneficial for Reducing Pain, Stiffness in Knee Osteoarthritis

The pivotal Phase III OASIS 1 and 2 studies both met all primary endpoints with elinzanetan reducing symptoms over 12 weeks compared to placebo. Full data for the duo of Phase III studies—OASIS 1 and 2—has been published in The Journal of the American Medical Association (JAMA). The trials evaluated the efficacy and safety of the investigational compound elinzanetant for the treatment of moderate to severe vasomotor symptoms (VMS), or hot flashes, associated with menopause.1.

Results from Phase III Duo Show Elinzanetant Significantly Reduced Frequency and Severity of Hot Flashes Associated with Menopause

Older adults who spend less time in their designated HbA1c range have higher risks for Alzheimer’s disease and dementias. Time below HbA1c range of 60% or higher increased risk for dementia. Older adults with diabetes who spend less time within their individualized HbA1c target range have a higher risk...

Spending less time in HbA1c target range may increase dementia risk for older adults

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

writer

Shin

Statins are widely recognized for their role in lowering low-density lipoprotein (LDL) cholesterol and reducing the risk of heart disease. But new research from the Cholesterol Treatment Trialists’ Collaboration (CTSU) has revealed that these life-saving medications may come with a small but significant drawback—an increased risk of developing diabetes, particularly in individuals already predisposed to the condition.

Statins and Diabetes: New Comprehensive Research Confirms Elevated Risk

A new study reveals dialysis increases life expectancy but reduces time at home for older adults below the eGFR threshold of 12 mL/min/1.73 m². Older adults who could not get a kidney transplant and turned to dialysis instead when their glomerular filtration rate (eGFR) fell < 12 mL/min/1.73 m2 had moderate increases in life expectancy and less time at home, a recent study reported.1.

Dialysis Extends Life in Older Adults with eGFR < 12 mL/min/1.73 m²

Salem, OH

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

contributor

Northern Kentucky Tribune

Every day, 8-year-old Emma sits in a small garden outside her grandmother’s home in Salem, Ohio, writing letters to her mom and sometimes singing songs her mother used to sing to her.

Thousands of parents die of overdoses; advocates say their kids need more help

Findings suggest a heterogeneous makeup of seronegative enteropathies, presenting difficulty in diagnosing patients with villous atrophy and negative celiac serologic testing. Affecting approximately 1% of the population in the United States, celiac disease, an immune response due to the ingestion of gluten in genetically susceptible individuals, is the most common enteropathy.1,2 Studies have estimated approximately 93% of patients with duodenal villous atrophy have seropositive celiac disease, defined as the serologic presence of IgA tissue transglutaminase and/or endomysial antibodies.3.

The Clinical Challenge of Seronegative Villous Atrophy: A Preview

This is the second installment of a 6-part series on the management of polycystic ovary syndrome (PCOS). In this installment, Danielle R. Stratton, DNP, RN, PPCNP-BC, discusses obesity and the significant impact it can have on patients with PCOS. This is a condition that most females with PCOS battle from adolescence through end of life.

Polycystic Ovary Syndrome and Obesity

There are tens of millions of people in the U.S. taking the cholesterol-lowering medications known as statins to prevent heart disease. This could be because the U.S. Preventative Services Task Force advises healthcare professionals to prescribe statins in patients ages 40 to 75 who have at least one risk factor for heart disease, such as diabetes or dyslipidemia, and an estimated 10-year cardiovascular risk of 10 percent or more.

Glaucoma joins growing list of statin side effects

NewsBreak

Transfusion Independence Sustained With Imetelstat in Low-Risk MDS

Mikkael A. Sekeres MD, MS, discusses transfusion independence rates with imetelstat in patients with low- to intermediate-1 risk myelodysplastic syndromes. Mikkael A. Sekeres MD, MS, professor...

Transfusion Independence Sustained With Imetelstat in Low-Risk MDS

Comments / 0