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A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models – all without showing signs of toxicity. Medulloblastoma is the most common malignant brain tumor in children. Survival rates vary according to which one of the four subtypes...

Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma

Health

Medically reviewed by Christopher Lee, MDMedically reviewed by Christopher Lee, MDHeart cancer develops when abnormal cells in the heart muscle or surrounding tissues grow uncontrollably, forming a malignant (cancerous) tumor. Cancerous heart tumors (known as cardiac sarcomas) are extremely rare, accounting for less than 0.028% of all cancer diagnoses annually.  Secondary heart cancer is when cancer cells metastasize (spread) to the heart from a tumor that started in nearby organs or body tissues. Secondary heart cancer is about 30 to 50 times more common than primary heart cancer. However, it is still rare, affecting approximately 10% of people with lung cancer,...

Signs and Symptoms of Heart Cancer

When lung cancer spreads beyond the lungs, it usually first affects nearby lymph nodes. But doctors don’t usually consider lung cancer to be “metastatic” until it has spread to more distant parts of the body. Lung cancer can spread throughout the body in several ways. Cancerous cells...

Where Lung Cancer Spreads First

The Collaborative Ocular Oncology Group Study Number 2 (COOG2) prospectively validated a prognostic tool using positive RNA expression of Preferentially Expressed Antigen in Melanoma (PRAME)—a biomarker known to be effective in identifying type 1 uveal melanoma tumors at increased risk of metastasis—along with previously validated 15-gene expression profile (15-GEP) data for predicting metastasis in patients with certain types of uveal melanoma. While the integrated tool showed improved predictive accuracy over the use of individual predictors, additional studies are needed to evaluate its potential value for widespread use.

An Integrated 15-GEP/ Tool May Improve Uveal Melanoma Prognostication

Reuters

(Reuters) -The U.S. Food and Drug Administration on Tuesday approved Johnson & Johnson's chemotherapy-free combination treatment for a type of non-small cell lung cancer, setting up a challenge for AstraZeneca's blockbuster drug Tagrisso.

J&J's chemotherapy-free treatment for lung cancer gets US approval

Cancer Health

In 2006, Diana Lindsay, who had never so much as held a cigarette, was diagnosed with stage 4 lung cancer. It had metastasized to both lungs, her brain and lymph nodes. Keith Eaton, MD, PhD, clinical director of thoracic, head and neck medical oncology at Fred Hutch Cancer Center, told her that a typical patient in this situation would have about nine months to live. But he also observed that she seemed remarkably strong and vital. “He said, ‘You don’t look like my normal lung cancer patient,’” said Lindsay, who had just returned from a business trip to Europe. She was 54 at the time. “He didn’t want to take away the health I had for the limited time I had to live.”

20 Years Since an EGFR Discovery, a Woman With Stage IV Lung Cancer Is Thriving

Toni English’s medical team was giddy. It was six weeks after English had completed an experimental cancer treatment, and she had arrived at the Orlando Health Cancer Institute in Florida with her husband to see the results of her latest scan. Her team gathered in a patient exam room...

A newly approved ‘living drug’ could save more cancer patients’ lives

Thyroid cancer stages range from 1 to 4 (sometimes referred to in Roman numerals as I, II, III, and IV). Stage 4 thyroid cancer is the most serious; stage 1 is the least severe. The stage of someone's cancer is determined by the size and spread of cancer cells from a tumor's primary site, in this case, the thyroid gland.

What Are the Stages of Thyroid Cancer?

Researchers have recently discovered a novel type of RNA known as circular RNAs (circRNAs). These molecules form when covalent bonds link the ends of a molecule of RNA together to form a circle. This can also make them very difficult to detect with traditional techniques, which is probably why they flew under the radar for so long. But circRNAs perform biological functions in different cells; they may be translated into proteins, or act like microRNAs or inhibitors that regulate the function of other molecules. CircRNAs have also been linked to some diseases, including diabetes, cardiovascular disease, and cancer.

What are Circular RNAs & Can They Aid Cancer Treatment?

A study published in the American Journal of Roentgenology (AJR) highlights the role of soft tissue, particularly when associated with vessel encasement and luminal narrowing, in raising suspicion for local recurrence (LR) after pancreatic ductal adenocarcinoma (PDAC) PDAC resection. “This AJR study provides insight into findings described in the Society...

New Soft Tissue on CT Suggests Local Recurrence After Pancreatic Cancer Resection

San Francisco, CA

Medical News Today

A ketogenic diet, combined with a new therapy, may help starve pancreatic cancer cells and shrink tumors, a mice study has shown.

A ketogenic diet may help block the development of pancreatic cancer

Laura J. Chambers, DO, discusses the role of genetic testing and PARP inhibitor maintenance therapy for patients with ovarian cancer. Laura J. Chambers, DO, assistant professor, Division of Gynecologic Oncology, The Ohio State University, The Ohio State Comprehensive Cancer Center—James, discusses the role of genetic testing on treatment decisions regarding PARP inhibitor maintenance therapy for patients with ovarian cancer.

Dr Chambers on the Role of Genetic Testing and PARP Inhibitors in Ovarian Cancer

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function. It is a major risk factor for cirrhosis and liver cancer. And because treatment options are limited, MASH is the second leading cause for liver transplants...

Macrophage mix helps determine rate and fate of fatty liver disease

Medically reviewed by Marla Anderson, MDMedically reviewed by Marla Anderson, MDNon-small cell lung cancer (NSCLC) is a type of cancer that begins in the tissues of the lungs. About 80-85% of all lung cancer cases in the United States are classified as NSCLC. NSCLC occurs when the cells that line the surface of the lung airways change and mutate. When these abnormal cells rapidly divide and multiply, they lead to cancer. The most common cause of NSCLC is smoking, with about 90% of lung cancer cases being related to tobacco smoke exposure. It is possible to be diagnosed with NSCLC if you...

What Causes Non-Small Cell Lung Cancer (NSCLC)?

Immunotherapy May Facilitate Surgery and Improve Outcomes for Patients With High-Risk Liver Cancer. Patients with liver cancer who received immune checkpoint inhibitors (ICIs) before surgery—including those who would not have been eligible for surgery by conventional criteria—had similar outcomes to patients who received surgery upfront, according to results from a retrospective study published in Cancer Research Communications, a journal of the American Association for Cancer Research (AACR).

Immunotherapy Before Surgery May Improve Outcomes for Patients With Liver Cancer

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Total Apex Sports & Entertainment

We all struggle with things like love, career, and business. However, some zodiac signs struggle for a long period before they get a breakthrough. August 27 will be a great day for three lucky signs whose struggles will end.

3 Zodiac Signs Who Will Stop Struggling on August 27, 2024

Small cell lung cancer (SCLC) is a fast-growing cancer that develops in cells within the lung. A range of medical tests and procedures are available to help doctors diagnose SCLC and create an appropriate treatment plan. Lung cancer is a complex disease comprising various subtypes. A person who receives a...

How do doctors diagnose small cell lung cancer?

UPI News

A new type of cancer drug might help treat brain diseases like Alzheimer's, studies suggest.

New cancer drugs might also help treat Alzheimer's

Doctors have initiated the world's first trial using BNT116 created by the German firm BioNTech (BNTX) for an mRNA lung cancer vaccine across seven countries, a significant step that may change cancer treatment dramatically. The phase 1 clinical trial is currently taking place at 34 research centers in the UK,...

World's First Lung Cancer Vaccine Trial Launched

Investigators previously assessed treatment with opaganib in patients with advanced cholangiocarcinoma and prostate cancer. The FDA has granted orphan drug designation to opaganib (ABC294640), an investigational SPHK2 selective inhibitor, as a treatment for pediatric patients with neuroblastoma, according to a press release from the developer, RedHill Biopharma Ltd.1. Investigators hypothesize...

Opaganib Earns FDA Orphan Drug Status in Neuroblastoma

NewsBreak

The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

Genome Medicine volume 16, Article number: 107 (2024) Cite this article. Poly (ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitors (PARPi) are targeted therapies approved for homologous...

The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

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