Columbus, OH

New Haven, CT

More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was at Harvard, discovered a type of T cell in humans that suppresses the immune system; they later found that these so-called regulatory T cells, when defective, are an underlying cause of autoimmune disease, specifically multiple sclerosis (MS). For many years, however, the mechanism behind this dysfunction has remained unclear.

Study reveals molecular mechanism behind MS and other autoimmune diseases

BMC Infectious Diseases volume 24, Article number: 895 (2024) Cite this article. Patients on B cell immunosuppressive treatments have been shown to have persistent infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, a woman treated with ibrutinib for chronic lymphocytic leukemia experienced more than 40 days of coronavirus disease 2019 (COVID-19) infection. Unexpectedly, her peripheral blood experiments showed a normal SARS-CoV-2-specific antibody level and a relatively elevated percentage of CD19 + B cells, while an obvious decrease in the percentages of NK cells, CD4 + T cells and CD8 + T cells. Further SARS-CoV-2-specific T cell analysis in this patient indicated a significant decrease in the percentage of SARS-CoV-2-specific IFN-γ, TNF-α or IL-2 producing CD4 + T or CD8 + T cells. Most notably, ten days after the cease of ibrutinib, the PCR for SARS-CoV-2 turned negative and the reduced proportions of peripheral CD4 + T cells and CD8 + T cells recovered. Our research predicted that the depleted B-cell function therapies may play considerable role in the development of long COVID-19 and the abnormal T-cell subset distribution might be the underlying mechanism.

A case report of prolonged viral shedding of SARS-CoV-2 in a patient who receive ibrutinib for CLL therapy

Genome Medicine volume 16, Article number: 108 (2024) Cite this article. Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cellular proliferation. The compensatory mechanisms that facilitate oncogenesis in bBRCA1/2 tumors remain unclear.

Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors

Interesting Engineering

Researchers at Sweden's Lund University conducted the stimulator testing on animals.

New injectable pacemaker corrects irregular heart beat for 5 days before dissolving

People with single-gene variants associated with autism display altered attentional skills compared with those with idiopathic autism. More specifically, those carrying DYRK1A variants show atypical responses in an auditory task, whereas those carrying SCN2A variants show atypical responses in a visual task. Spectrum has previously reported on researcher Caitlin Hudac’s mobile lab that enables her to test people in their homes. Autism Research.

Congenital heart disease; community-driven policymaking; empathy in autism

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NewsNinja

‘Any meat items my dogs refuse to eat, I no longer eat.’ It’s said that animals have a “sixth sense,” which affords them an insight human beings cannot match. There are clips of security camera earthquake footage where pets can be seen wigging out seconds before tremors begin.

‘It ain’t food anymore.’: Dairy Queen customer warns against chicken after his dog refuses to eat it

Qiagen and AstraZeneca are expanding their diagnostics partnership, with plans to explore the use of genomic profiling in chronic diseases beyond cancer. The long-time collaborators, which previously worked together to identify patients with specific lung tumors susceptible to targeted treatments, will now develop new genotyping assays based on Qiagen’s QIAstat‑Dx multiplex PCR system.

Qiagen, AstraZeneca expand companion diagnostic partnership to chronic diseases beyond cancer

Massachusetts State

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Dianna Carney

Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, has recently introduced a tiny six-pound dog named Alistair who is looking for his forever home. At only one year old, this little boy is a sweet dog who is thought to be a Maltese, "but we can’t make any guarantees that he would be suitable for those with allergies," explains the nonprofit animal rescue.

Meet The Tiny 6lb Dog Looking For Love

Georgia State

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Crisp County, GA

Daily Coffee Press

On Wednesday, the Georgia Bureau of Investigation announced the arrest of 24 individuals following Operation Shyne Down. The GBI and other agencies served a total of 120 warrants on the suspects involved in the investigation, which targeted the criminal street gang G-Shyne Bloods and their involvement in criminal activities in Crisp County, Georgia.

Operation Results in More than 20 Charged with Gang Offenses, RICO, and more

In August 2023, Gut, a journal published by BMJ, released a study of over 24,000 patients with Parkinson’s disease, finding that certain gastrointestinal disorders — such as difficulty swallowing, constipation, and irritable bowel syndrome (IBS) — might specifically predict Parkinson’s disease. The study aimed to methodically test Braak’s hypothesis, first postulated in 2003, which states that an unknown virus or bacteria in the gut could be a cause of Parkinson’s disease.

A Systems Approach To Parkinson's Disease

Researchers have found that a dopamine-related treatment could alleviate physical symptoms of Alzheimer's disease (AD) in the brain and improve memory. The corresponding study was published in Science Signaling. Previous studies indicate that increasing the production of an enzyme called neprilysin in the brain via genetic manipulation results in fewer...

Dopamine Treatment Shows Promise for Alzheimer's Disease

The medical director of the Toronto Memory Program at the University of Toronto gave clinical perspective on the promise of mivelsiran, an investigational RNA interference therapeutic, and the idea behind using RNA therapies to treat Alzheimer disease. [WATCH TIME: 5 minutes]. WATCH TIME: 5 minutes. "Going upstream is very attractive...

Expanding the Potential to Treat Alzheimer Disease With RNA Therapeutics: Sharon Cohen, MD, FRCPC

Adrenal cancer is a rare but serious condition that affects the adrenal glands, which sit atop your kidneys. These glands produce hormones that regulate metabolism, immune system, blood pressure, and other essential functions. Adrenal cancer can disrupt these processes, leading to a variety of symptoms and complications. Understanding this disease is crucial for early detection and treatment. In this post, we'll share 25 facts about adrenal cancer to help you grasp its impact, symptoms, and treatment options. From the basics of what adrenal glands do to the latest advancements in medical research, you'll gain a comprehensive overview of this challenging condition.

25 Facts About Adrenal Cancer

Janusz Racz, a 67-year-old lung cancer patient, is the first to receive this groundbreaking vaccine.

67-year-old receives world-first lung cancer vaccine as human trials begin

According to officials with the Southern District of Georgia, two recently unsealed federal indictments have charged 23 defendants in a series of broad conspiracies involving the use of drones to smuggle methamphetamine, marijuana, and cell phones into state prisons in Georgia.

23 Defendants Charged in Federal Indictments for Drone-Smuggling Drug Operation in Georgia

Stanford, CA

Neuroscientists at Stanford have linked Alzheimer’s disease to the disruption of brain metabolism via the kynurenine pathway, which is affected by amyloid plaque and tau proteins. Their research has demonstrated that drugs blocking this pathway can restore cognitive function in Alzheimer’s mice by improving brain metabolism. This discovery not...

Stanford Reverses Cognitive Decline in Alzheimer’s With Brain Metabolism Drug

We carefully vet all products and services featured on mindbodygreen using our commerce guidelines. Our selections are never influenced by the commissions earned from our links. Late last year, Samara Maloney, one of the Caribbean’s most beloved social media influencers, passed away unexpectedly from a ruptured brain aneurysm, plummeting the...

Neurologists Speak Out: 5 Ways To Protect Yourself From A Brain Aneurysm

The largest glaucoma diagnosis postponement was seen in the early menopause group (3.6 years) and the smallest observed in the late menopause group (2.7 years). Photo: Schering. Click image to enlarge. Researchers at Atlanta’s Emory University recently investigated ways in which estrogen may aid in delaying development of open-angle glaucoma....

Hormone Therapy in Postmenopausal Women Linked with Later Glaucoma Diagnosis

Christina Zielinski and her team have discovered that sodium chloride can enhance the activity of specific immune cells in combating cancer. Sodium chloride, commonly known as “table salt,” was once a highly prized commodity. Today, it is both affordable and essential in the kitchen. Unsurprisingly, salt has also made its way into our everyday language, often carrying negative connotations. However, the phrase “rubbing salt into the wound” may soon take on a positive meaning, particularly in the context of cancer therapy.

Surprise Discovery: Scientists Discover New Anti-Cancer Potential of Salt

Atlanta, GA

Two men, Alvin Demar and Joshua Carter, have been sentenced to federal prison for trafficking firearms, with some later recovered at crime scenes across multiple states and Canada. A third man, Jamal Plunkett, was sentenced for possessing one of these trafficked weapons.

Georgia Men Sentenced in Multi-State Firearms Trafficking Operation Tied to Violent Crime

NewsBreak

Exploring the potential mechanisms of Rehmannia glutinosa in treating sepsis based on network pharmacology

BMC Infectious Diseases volume 24, Article number: 893 (2024) Cite this article. The present study utilized network pharmacology to identify therapeutic targets and mechanisms of Rehmannia...

Exploring the potential mechanisms of Rehmannia glutinosa in treating sepsis based on network pharmacology

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