Mountain View, CA

New York City, NY

Co-founded in 1994 in New York City by Jim and Marilyn Simons, the Simons Foundation works to advance the frontiers of research in mathematics and the basic sciences. The foundation invites applications for its Targeted Grants to Institutes program, which will award grants of up to $250,000 per year for up to three years to established institutes or centers in mathematics, theoretical physics, and theoretical computer science to strengthen contacts within the international scientific community and enable institutes to extend and enhance their missions. This program will not provide primary support for operating or establishing an institute. The foundation expects to award up to five grants each year.

Simons Foundation invites applications for Targeted Grants to Institutes Program

Pennsylvania State

Allentown, PA

The PPL Foundation in Allentown, Pennsylvania—the philanthropic arm of PPL Electric Utilities—has announced grants totaling $1 million in support of more than 50 nonprofit organizations working to promote the development of sustainable communities. The grants will help fund programs across the power company’s 29-county service territory in central...

PPL Foundation awards $1 million to Pennsylvania nonprofits

High School Inc. Academies Foundation has announced a three-year, $1 million grant from the Larry and Helen Hoag Foundation in support of its Empowering the Workforce of Tomorrow initiative. The grant will enable High School Inc. to expand and enhance its education and workforce development programs in Orange County, California....

High School Inc. awarded $1 million by Hoag Foundation

Fulton County, GA

The Toyota USA Foundation has announced a five-year commitment of up to $8.6 million to prepare Georgia’s Fulton County Schools (FCS) students for careers in science, technology, engineering, and math (STEM). The commitment is part of the Driving Possibilities initiative, which aims to close educational gaps for PreK-12 students...

Toyota USA Foundation commits $8.6 million for STEM education

It’s important to communicate with the patient’s comanaging doctors to adjust necessary medications. There are four direct oral anticoagulants approved for atrial fibrillation and venous thromboembolism: apixaban (Eliquis), dabigatran (Pradaxa), edoxaban (Savaysa) and rivaroxaban (Xarelto). Click image to enlarge. The body is an interconnected system and, as clinicians...

Some Blood Thinners May Increase Conversion to Wet AMD

South Carolina State

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Florida State

Akeena

Recent data from the U.S. Census Bureau reveals a significant trend: Florida is experiencing a substantial outflow of residents. According to the latest figures, over 275,000 individuals left Florida for other states in 2022.

Florida Sees Surge in Departures as Hundreds of Thousands Move Out

Lewy Body Dementia (LBD), sometimes called Dementia with Lewy Bodies, is the third most common form of dementia (after Alzheimer’s disease and vascular dementia), affecting approximately 1.3 million American adults and accounting for up to 30% of dementia cases. Like Alzheimer’s and vascular dementia, LBD is progressive and irreversible, and is marked by mental decline. It often occurs alongside other forms of dementia.

What is Lewy Body Dementia?

Stanford, CA

Neuroscientists at Stanford have linked Alzheimer’s disease to the disruption of brain metabolism via the kynurenine pathway, which is affected by amyloid plaque and tau proteins. Their research has demonstrated that drugs blocking this pathway can restore cognitive function in Alzheimer’s mice by improving brain metabolism. This discovery not...

Stanford Reverses Cognitive Decline in Alzheimer’s With Brain Metabolism Drug

Approved a new initial treatment for advanced non-small-cell lung cancer after clinical trials showed patients lived longer without disease progression, compared to the standard treatment currently used. The chemotherapy-free combination involves two drugs, one of which has never been approved for use in the U.S. called lazertinib, which will be...

FDA Approves New Treatment for Non-Small-Cell Lung Cancer

InspireMore

Parkinson’s disease is a debilitating, degenerative brain […]
The post Man With Parkinson’s Disease Shares Incredible Before & After Videos Of Groundbreaking Treatment appeared first on InspireMore.

Man With Parkinson’s Disease Shares Incredible Before & After Videos Of Groundbreaking Treatment

A new study reveals dialysis increases life expectancy but reduces time at home for older adults below the eGFR threshold of 12 mL/min/1.73 m². Older adults who could not get a kidney transplant and turned to dialysis instead when their glomerular filtration rate (eGFR) fell < 12 mL/min/1.73 m2 had moderate increases in life expectancy and less time at home, a recent study reported.1.

Dialysis Extends Life in Older Adults with eGFR < 12 mL/min/1.73 m²

Metformin, a widely-used medication for type 2 diabetes, has attracted significant attention in recent years for its potential benefits beyond blood sugar control. Research suggests that metformin may hold promise in slowing down the aging process and extending healthy lifespan. The ongoing TAME (Targeting Aging with Metformin) clinical trial is set to provide crucial evidence on whether this potential can be realized.

Unlocking Metformin’s Anti-Aging Potential: Awaiting the Groundbreaking TAME Trial Results

Researchers have found that a dopamine-related treatment could alleviate physical symptoms of Alzheimer's disease (AD) in the brain and improve memory. The corresponding study was published in Science Signaling. Previous studies indicate that increasing the production of an enzyme called neprilysin in the brain via genetic manipulation results in fewer...

Dopamine Treatment Shows Promise for Alzheimer's Disease

Eating the seaweed Ecklonia cava may be able to slow down or prevent Parkinson's disease, according to a 2024 study. Researchers found that antioxidants in the seaweed – which is often used in soups and salads in Asian cuisine – may protect our neurons from free radicals to prevent this debilitating disease.

Eating Seaweed May Help Prevent Parkinson's, Study Finds

Interesting Engineering

Researchers at Sweden's Lund University conducted the stimulator testing on animals.

New injectable pacemaker corrects irregular heart beat for 5 days before dissolving

The Marijuana Herald

The Marijuana Herald - Marijuana news and information
A new study published in the journal Psychopharmacology shows that cannabidiol (CBD) may be useful as a sleep aid for individuals suffering from insomnia. Conducted by researchers from Swinburne University of Technology and the Institute for Breathing and Sleep at Austin Hospital, the randomized controlled pilot trial explored whether nightly use of CBD impacts daytime … 
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The post Study: Nightly CBD Use for Insomnia Found Safe, Preserves Daytime Cognitive Function appeared first on The Marijuana Herald.

Study: Nightly CBD Use for Insomnia Found Safe, Preserves Daytime Cognitive Function

The medical director of the Toronto Memory Program at the University of Toronto gave clinical perspective on the promise of mivelsiran, an investigational RNA interference therapeutic, and the idea behind using RNA therapies to treat Alzheimer disease. [WATCH TIME: 5 minutes]. WATCH TIME: 5 minutes. "Going upstream is very attractive...

Expanding the Potential to Treat Alzheimer Disease With RNA Therapeutics: Sharon Cohen, MD, FRCPC

In August 2023, Gut, a journal published by BMJ, released a study of over 24,000 patients with Parkinson’s disease, finding that certain gastrointestinal disorders — such as difficulty swallowing, constipation, and irritable bowel syndrome (IBS) — might specifically predict Parkinson’s disease. The study aimed to methodically test Braak’s hypothesis, first postulated in 2003, which states that an unknown virus or bacteria in the gut could be a cause of Parkinson’s disease.

A Systems Approach To Parkinson's Disease

BMC Infectious Diseases volume 24, Article number: 895 (2024) Cite this article. Patients on B cell immunosuppressive treatments have been shown to have persistent infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, a woman treated with ibrutinib for chronic lymphocytic leukemia experienced more than 40 days of coronavirus disease 2019 (COVID-19) infection. Unexpectedly, her peripheral blood experiments showed a normal SARS-CoV-2-specific antibody level and a relatively elevated percentage of CD19 + B cells, while an obvious decrease in the percentages of NK cells, CD4 + T cells and CD8 + T cells. Further SARS-CoV-2-specific T cell analysis in this patient indicated a significant decrease in the percentage of SARS-CoV-2-specific IFN-γ, TNF-α or IL-2 producing CD4 + T or CD8 + T cells. Most notably, ten days after the cease of ibrutinib, the PCR for SARS-CoV-2 turned negative and the reduced proportions of peripheral CD4 + T cells and CD8 + T cells recovered. Our research predicted that the depleted B-cell function therapies may play considerable role in the development of long COVID-19 and the abnormal T-cell subset distribution might be the underlying mechanism.

A case report of prolonged viral shedding of SARS-CoV-2 in a patient who receive ibrutinib for CLL therapy

Treatment with an ARPI extended overall survival (OS), with a median OS of 38.7 months in the ARPI arm vs 21.7 months in the taxane arm and 21.8 months in the physician’s choice of treatment arm. Treatment with androgen receptor pathway inhibitors (ARPIs) led to an improved treatment response...

ARPIs achieve improved treatment response in patients with mCRPC and detectable ctDNA

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Parkinson’s Foundation awards nearly $3 million in research grants

The Parkinson’s Foundation has announced 33 grants totaling nearly $3 million to accelerate cutting-edge Parkinson’s disease (PD) research. The funding will support scientists conducting innovative studies across various aspects of...

Parkinson’s Foundation awards nearly $3 million in research grants

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