EBT-101, a CRISPR-based gene-editing therapy, was safe and well tolerated in an early study, but it did not prevent viral rebound in the first four participants who interrupted antiretroviral treatment, according to a report at the International AIDS Conference (#AIDS2024) in Munich. One person, however, did see a decline in his HIV reservoir, and viral rebound was delayed for four months.

CRISPR Gene Therapy Does Not Prevent HIV Rebound

Three HIV scientists exploring potential HIV cures received grants totaling $1.2 million from amfAR, the Foundation for AIDS Research. All three will focus on ways to eliminate the so-called HIV reservoir, where latent virus hides out, even when people are on successful treatment and their viral load is undetectable. (If treatment is stopped, the virus rebounds and begins its damage.)

Can Cancer Meds Play a Role in an HIV Cure? These Researchers Aim to Find Out

Long-acting injectable cabotegravir (CAB-LA) was safe and well tolerated as HIV pre-exposure prophylaxis (PrEP) before and during pregnancy in the follow-up phase of a global study among cisgender women. The analysis of outcomes from more than 300 pregnancies and infants will be presented at the 2024 International AIDS Conference (AIDS 2024) in Munich, Germany.

Long-Acting Injectable Cabotegravir for HIV Prevention is Safe in Pregnancy

About 7 million adults 65 or older are living with Alzheimer's disease in the U.S. It’s the most common cause of dementia, a gradual decline in memory, thinking, behavior and social skills. By 2050, the number of adults in the U.S. with Alzheimer's disease is projected to reach nearly 13 million.

How to screen for, reduce risk of and treat Alzheimer’s disease

Antiretroviral therapy (ART) has been a game-changer for people with HIV. But HIV is skilled at “hiding” and can reappear in the blood stream shortly after ART is stopped. That’s why NIAID and partners are investigating strategies to completely clear HIV from a person’s body, effectively curing them, or to reduce it to levels that can be suppressed by their own immune systems.

Broadly Neutralizing Antibodies Evaluated in Many HIV Cure Strategies

Miami, FL

Lamar McMullen of Miami is positively evangelical about long-acting injectables for HIV treatment. Currently, only one such medication is approved for injection every other month; others in the pipeline are intended to last even longer. Since giving up his once-a-day pill for a long-acting injectable, McMullen has been pleased with the results.

Getting Comfortable With Long-Acting Injectables

Review of: Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide. Hathaway J, Sha M, Hathaway D, et al. JAMA Ophthalmology, in press 2024. Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) prescribed to assist with weight management in patients with type 2 diabetes (T2D) or those who are overweight/obese, and there have been anecdotal reports of nonarteritic anterior ischemic optic neuropathy (NAION) in patients taking this medication. This single-center, observational study compared patients prescribed semaglutide to matched patients prescribed other medications for diabetes and found a greater risk of NAION in the semaglutide cohort, though additional studies are needed to verify this relationship and causality cannot be inferred.

Semaglutide May Be Associated With an Increased Risk of Developing NAION

A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death. The study, led by researchers at the National Institutes of Health’s National Cancer Institute, was published June 26, 2024, in...

For Healthy Adults, Taking Multivitamins Daily Is Not Associated With a Lower Risk Of Death

You’ve been told you have high blood pressure. You may have tried to lower it by reducing the salt in your diet and exercising. This has helped, but your readings are still too high, and your doctor has prescribed a medication. Your blood pressure now looks good, but the medication is making you feel lightheaded.

High Blood Pressure Medication Side Effects: What You Should Know

Philadelphia, NY

Thanks to a $24 million institutional investment from Wistar, The Wistar Institute is building a new HIV Cure and Viral Disease Center dedicated to HIV research, according to a news release. Philadelphia-based Wistar is one of the top independent nonprofit institutions researching HIV, cancer, immunology and other infectious diseases. Wistar...

Wistar Institute Launches Center Dedicated to HIV Cure Research

Strong bones help maintain mobility and enhance quality of life. People with HIV are more prone to bone loss and fractures, but you can take steps to improve bone health. Bone is living tissue largely made up of minerals and collagen. Cells called osteoblasts continually add new bone tissue, while osteoclasts dissolve old bone. As people age, bone resorption starts to outpace bone formation, and bone mass naturally declines. Osteopenia is an earlier stage of bone loss, which can progress to osteoporosis.

HIV and Your Bones

For decades, sodium restriction has been a cornerstone in the management of heart failure, driven by the belief that reducing salt intake helps control fluid retention and improve outcomes. Heart failure is marked by the activation of the renin-angiotensin and noradrenergic systems, leading to fluid retention. Consequently, limiting sodium intake has been seen as a way to mitigate these effects and reduce edema and other complications associated with heart failure.

Salt restriction in heart failure

Indiana State

Eighteen people living with HIV in Indiana were arrested between 2001 and 2019 for donating plasma, though, thanks to effective screening methods, none of them posed a risk of transmitting the virus, found a new report by the Williams Institute. The Williams Institute is a research center focusing on law...

People With HIV Have Been Arrested in Indiana for Donating Plasma

A policy brief written by health advocate experts urges Medicaid leadership to capitalize on the promise of long-acting medications to treat and prevent HIV. The brief spells out a series of recommendations to ensure that people eligible for Medicaid have access to these “game-changing” injectable HIV meds. The...

Medicaid Urged to Ensure Access to Long-Acting Meds That Treat and Prevent HIV

HIV stigma in health care is real and harmful. Fortunately, health care providers can now take the antiviral drug Stigmavir to treat their stigma. Unfortunately, the drug is fictitious, but you can watch a real ad for it on YouTube. Casey House, an AIDS service provider in Toronto, created the...

Stigmavir to Treat HIV Stigma?

Coffee County, GA

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Daily Coffee Press

Earlier this month, a grand jury indicted over fifteen people on felony charges in Coffee County. Seven individuals face drug offenses, while others were indicted for assault, stalking, theft, and more. Several were indicted for drug possession, including two defendants facing trafficking charges after arrests earlier this year: Kenchisa Teraki Carter and Zarionna Hollaway.

Coffee County Grand Jury Indicts Two on Drug Trafficking Charges and More

Acute kidney injury (AKI) is one of the most frequent complications of cardiac surgery and the cause is complex. Renal hypoperfusion from decreased glomerular filtration rate after cardiopulmonary bypass is a major contributor. 1 This in combination with exogenous toxins, endogenous metabolites, oxidative stress, bleeding and reperfusion injury can all...

The PROTECTION Trial – A Randomized Trial of Intravenous Amino Acids for Kidney Protection

Jacksonville, FL

Jacksonville Today

A former Jacksonville police officer pleaded guilty Tuesday to enticement of a minor to engage in unlawful sexual activity, according to the U.S. Attorney’s Office. Josue Garriga III, 34, faces a mandatory penalty of 10 years to life in federal prison and must register as a sex offender. A sentencing date has not been set.

Former cop pleads guilty to enticing 17-year-old girl

A Year of Hepatitis Advances to Mark World Hepatitis Day. Viral hepatitis affects the lives of about one in twenty people in the world, resulting in over a million deaths each year. NIAID is working on many ways to prevent and treat the different types of hepatitis, including the development of vaccines and improved therapeutics and diagnostics.

NIAID Research to Eliminate the Threat of Viral Hepatitis Across the Globe

Office-based BP measurements cannot sufficiently and accurately predict individuals with the lowest BP values identified using 24-hour BP recording, leading the study authors to argue for its use in patients at risk of glaucoma progression, particularly those who demonstrate optic disc hemorrhage. Photo: Michael Chaglasian, OD. Click image to enlarge.

Lower Blood Pressure Associated with Faster Glaucoma Progression Rate

NewsBreak

Exploratory Analysis Associates HIV Drug Abacavir With Elevated Cardiovascular Disease Risk

Current or previous use of the antiretroviral drug abacavir was associated with an elevated risk of major adverse cardiovascular events (MACE) in people with HIV, according...

Exploratory Analysis Associates HIV Drug Abacavir With Elevated Cardiovascular Disease Risk

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