Oakland A's at San Francisco Giants odds, picks and predictions

The Oakland A’s (45-64) and San Francisco Giants (53-56) wrap up a 2-game set at Oracle Park Wednesday. First pitch is scheduled for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the A’s vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: A’s lead 1-0

The A’s won 5-2 as +167 underdogs in the Tuesday opener as the Under (8) hit, and we cashed on the run line and the total. LHP JP Sears pitched 7 shutout innings, yielding just 3 hits and a walk with 9 K’s while the A’s offense hit 4 HRs.

Giants C Patrick Bailey singled in a run in the 9th inning, a rare highlight for a San Francisco team that had just 5 hits on the night. The loss ended a 4-game Giants win streak.

A’s at Giants projected starters

RHP Ross Stripling vs. RHP Logan Webb

Stripling (2-9, 6.02 ERA) makes his 13th start. He has a 1.58 WHIP, 2.1 BB/9 and 5.6 K/9 through 61 1/3 innings.

• Last start: Win, 5 2/3 IP, 5 ER, 6 H, 2 BB, 3 K in 6-5 victory at Los Angeles Angels Thursday
• 2024 road stats: 1-4, 6.12 ERA (32 1/3 IP, 22 ER), 1.52 WHIP, 5.0 K/9 in 6 starts
• Career vs. Giants: 2-3, 3.20 ERA (45 IP, 16 ER), 1.00 WHIP, 6.8 K/9 in 15 appearances (5 starts) — last faced San Francisco in 2020

Webb (7-8, 3.72 ERA) makes his 23rd start. He has a 1.32 WHIP, 2.3 BB/9 and 7.6 K/9 through 135 1/3 innings.

• Last start: No-decision, 5 IP, 4 ER, 9 H, 3 BB, 4 K in 6-4 loss at Los Angeles Dodgers Thursday
• 2024 home stats: 4-3, 3.00 ERA (60 IP, 20 ER), 1.13 WHIP, 6.6 K/9 in 9 starts
• Career vs. A’s: 1-2, 5.68 ERA (25 1/3 IP, 16 ER), 1.46 WHIP, 7.1 K/9 in 5 starts — last start in 2022

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

A’s at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:45 p.m. ET.

• Moneyline (ML): A’s +170 (bet $100 to win $170) | Giants -210 (bet $210 to win $100)
• Run line (RL)/Against the spread (ATS): A’s +1.5 (-120) | Giants -1.5 (+100)
• Over/Under (O/U): 7.5 (O: -115 | U: -105)

A’s at Giants picks and predictions

Prediction

Giants 5, A’s 4

The Giants (-210) will likely bounce back after Tuesday’s loss, but they’re a little overvalued at this number.

PASS. Bet the run line and/or total instead.

Both starters have allowed 4 or more earned runs in their last 3 starts, but the A’s offense may be more reliable going forward. Oakland has scored 5 or more runs in 4 of its last 5 games, while the Giants put up just 2 runs in the Tuesday opener after trading 1 of their best hitters in DH Jorge Soler to the Atlanta Braves Monday.

The A’s are 10-4 straight up and on the run line over their last 14 games, and at the very least, they should be able to keep this one close.

BET A’S +1.5 (-120).

Webb has allowed 15 earned runs over his last 16 innings, while Stripling has given up 15 over his last 14 1/3. To make matters worse for Webb, Oakland is averaging 5 runs over its last 5 games, which should help the Over hit at such a low number. However, I’m bearish on San Francisco’s offense moving forward without Soler.

LEAN OVER 7.5 (-115).

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