| Court | Start time (ET) | Tournament | Match | Results |
| Arthur Ashe Stadium | 12 p.m. | Men's | (13) Ben Shelton vs. Dominic Thiem | 6-4,6-2,6-2 |
| | Women's | Varvara Gracheva vs. (3) Coco Gauff | 2-6, 0-6 |
| 7 p.m. | Women's | Clara Burel vs. Sloane Stephens | |
| | Men's | Radu Albot vs. (2) Novak Djokovic | |
| Louis Armstrong Stadium | 11 a.m. | Women's | (7) Qinwen Zheng vs. Amanda Anisimova | 4-6, 6-4, 6-2 |
| | Men's | Camilo Ugo Carabelli vs. (12) Taylor Fritz | 5-7, 1-6, 2-6 |
| | Women's | (14) Madison Keys vs. Katerina Siniakova | |
| 7 p.m. | Men's | Aleksandar Kovacevic vs. (20) Frances Tiafoe | |
| | Women's | Priscilla Hon vs. (2) Aryna Sabalenka | |
| Grandstand | 11 a.m. | Men's | Maximillian Marterer vs. (4) Alexander Zverev | 2-6, 7-6 (7-5), 3-6, 2-6 |
| | Women's | Viktorija Golubic vs. (26) Paula Badosa | 0-6, 3-6 |
| | Men's | Gael Monfils vs. Diego Schwartzman | |
| Not before 6 p.m. | Women's | (20) Victoria Azarenka vs. Yuliia Starodubtseva | |
| Court 4 | 11 a.m. | Men's | Dominic Stricker vs. Francisco Comesana | 6-4, 3-6, 6-7 (4-7), 3-6 |
| | Women's | Tatjana Maria vs. Solana Sierra | 6-2, 6-3 |
| | Women's | Veronika Kudermetova vs. (33) Elise Mertens | |
| | Men's | (21) Sebastian Baez vs. Luciano Darderi | |
| Court 5 | 11 a.m. | Women's | (27) Elina Svitolina vs. Maria Lourdes Carle | 3-6, 6-3, 6-4 |
| | Men's | (6) Andrey Rublev vs. Thiago Seyboth Wild | 6-3, 7-6 (7-3), 7-5 |
| | Men's | Kyrian Jacquet vs. (9) Grigor Dimitrov | |
| | Women's | (8) Barbora Krejcikova vs. Marina Bassols Ribera | |
| Court 6 | 11 a.m. | Women's | Jule Niemeier vs. (32) Dayana Yastremska | 6-4, 6-7 (3-7), 6-4 |
| | Men's | Marton Fucsovics vs. (32) Jiri Lehecka | |
| | Men's | Rinky Hijikata vs. Alejandro Davidovich Fokina | |
| | Women's | (29) Ekaterina Alexandrova vs. Viktoriya Tomova | |
| Court 7 | 11 a.m. | Women's | Jacqueline Cristian vs. (12) Daria Kasatkina | 2-6, 4-6 |
| | Men's | Albert Ramos-Vinolas vs. Matteo Berrettini | 6-7 (2-7), 2-6, 3-6 |
| | Men's | Reilly Opelka vs. (18) Lorenzo Musetti | |
| Not before 4 p.m. | Women's | (13) Emma Navarro vs. Anna Blinkova | |
| Court 8 | 11 a.m. | Women's | Erika Andreeva vs. Yue Yuan | 6-3, 7-6 (9-7) |
| | Women's | Greet Minnen vs. Magdalena Frech | 7-5, 7-5 |
| | Men's | Yoshihito Nishioka vs. Miomir Kecmanovic | |
| | Men's | Arthur Cazaux vs. Pablo Carreno Busta | |
| Court 10 | 11 a.m. | Men's | (17) Ugo Humbert vs. Thiago Monteiro | 6-3, 6-4, 6-4 |
| | Women's | Oceane Dodin vs. Anhelina Kalinina | 1-6, 6-3, 1-6 |
| | Men's | Giovanni Mpetshi Perricard vs. Tomas Martin Etcheverry | |
| | Women's | Ana Bogdan vs. Arantxa Rus | |
| Court 11 | 11 a.m. | Men's | Juncheng Shang vs. (27) Alexander Bublik | 6-4, 3-6, 5-7, 6-3, 6-4 |
| | Women's | Peyton Stearns vs. Lesia Tsurenko | |
| | Men's | Christopher Eubanks vs. Arthur Rinderknech | |
| | Women's | Lulu Sun vs. Lucia Bronzetti | |
| Court 12 | 11 a.m. | Women's | (24) Donna Vekic vs. Kimberly Birrell | 6-4, 6-4 |
| | Men's | (28) Alexei Popyrin vs. Soonwoo Kwon | 7-5, 6-2, 6-3 |
| | Men's | (29) Francisco Cerundolo vs. Sebastian Ofner | |
| | Women's | McCartney Kessler vs. Marta Kostyuk | |
| Court 13 | 11 a.m. | Men's | Hugo Grenier vs. Mitchell Krueger | 6-4, 3-6, 4-6, 5-7 |
| | Women's | Tamara Korpatsch vs. Moyuka Uchijima | |
| | Women's | Ajla Tomljanovic vs. Ann Li | |
| | Men's | Laslo Djere vs. Jan-Lennard Struff | |
| Court 14 | 11 a.m. | Men's | Luca Nardi vs. Roberto Bautista Agut | 5-7, 6-7 (3-7), 6-5 (5-7) |
| | Women's | Maya Joint vs. Laura Siegemund | 6-4, 7-5 |
| | Men's | Alexander Shevchenko vs. Dominik Koepfer | |
| | Women's | Julia Grabher vs. Elena-Gabriela Ruse | |
| Court 15 | 11 a.m. | Women's | Diane Parry vs. Xiyu Wang | 7-6 (7-2), 7-6 (7-5) |
| | Men's | Pedro Martinez vs. Maks Kasnikowski | |
| | Women's | Magda Linette vs. Iva Jovic | |
| | Men's | Sumit Nagal vs. Tallon Griekspoor | |
| Court 16 | 11 a.m. | Men's | Jan Choinski vs. Roberto Carballes Baena | 2-6, 3-6, 7-5, 7-6 (7-5), 3-6 |
| | Men's | Alexandre Muller vs. Adam Walton | |
| | Women's | Chloe Paquet vs. Harriet Dark | |
| Stadium 17 | 11 a.m. | Women's | Yafan Wang vs. (9) Maria Sakkari | 6-2 |
| Not before 12:30 p.m. | Men's | (8) Casper Ruud vs. Yunchaokete Bu | 7-6 (7-2), 6-2, 6-2 |
| | Women's | Martina Trevisan vs. Taylor Townsend | |
| Not before 5 p.m. | Men's | (15) Holger Rune vs. Brandon Nakashima | |
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