MEDALIST (Fenaux et al. NEJM 2020) (Santini et al. ASH 2023, Abstr. 915) Please describe the similarities/differences between the two trials regarding the data related to defining transfusion independence. Compare/contrast the data from IMerge and MEDALIST for patients based on whether they received (a) 2 to <4 units, (b) 4...

Efficacy and Safety of 2L therapies for RS+ patients

Incorporating information from common blood tests can enhance cancer risk assessment in patients with abdominal symptoms, according to a study publishing July 30th in the open-access journal PLOS Medicine by Meena Rafiq from University College London, UK, and colleagues. Early cancer detection is key to successful treatment. However, many undiagnosed...

Routine blood test results can improve cancer risk assessment in patients with abdominal symptoms

Findings from the phase 3 E1910 study showed that blinatumomab extended overall survival when added to chemotherapy vs chemotherapy alone in B-cell precursor acute lymphoblastic leukemia. An overall survival (OS) benefit was observed when the immunotherapy blinatumomab (Blincyto) was added to consolidation chemotherapy in patients with B-cell precursor acute lymphoblastic...

Blinatumomab Improves 3-Year Survival in B-ALL vs Chemotherapy

Review of: Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide. Hathaway J, Sha M, Hathaway D, et al. JAMA Ophthalmology, in press 2024. Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) prescribed to assist with weight management in patients with type 2 diabetes (T2D) or those who are overweight/obese, and there have been anecdotal reports of nonarteritic anterior ischemic optic neuropathy (NAION) in patients taking this medication. This single-center, observational study compared patients prescribed semaglutide to matched patients prescribed other medications for diabetes and found a greater risk of NAION in the semaglutide cohort, though additional studies are needed to verify this relationship and causality cannot be inferred.

Semaglutide May Be Associated With an Increased Risk of Developing NAION

Turnstone Biologics is narrowing the focus of phase 1 trials of its lead tumor-infiltrating lymphocyte (TIL) therapy, with cutaneous melanoma and breast cancer no longer in the mix. The program, dubbed TIDAL-01, has been undergoing two phase 1 trials, including the STARLING study evaluating the therapy for the treatment of...

Turnstone narrows cell therapy focus to 'high unmet need' tumor indications

Colorado State

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David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

WEDNESDAY, Aug. 7, 2024 (HealthDay News) — For patients with preoperative iron deficiency anemia (IDA), intravenous (IV) iron treatment is associated with a significant reduction in 30-day postoperative mortality and morbidity compared with red blood cell (RBC) transfusion, according to research published online July 22 in Anesthesia & Analgesia.

Preoperative IV Iron Treatment Better for Iron Deficiency Anemia

Reuters

(Reuters) - Incyte said on Thursday its drug met the main goal in a late-stage trial evaluating it in patients with a form of blood cancer. The company said its drug Monjuvi, combined with Bristol Myers Squibb's drug, Revlimid, and Biogen's Rituxan achieved progression free survival in patients with follicular lymphoma (FL), when compared to Rituxan and Revlimid alone.

Incyte's blood cancer drug succeeds late-stage trial

Interesting Engineering

Patients experienced a significant reduction in pain, improved their quality of life, and even showed signs of cartilage regrowth.

Stem cell shot reverses osteoarthritis, repairs knee cartilage, cuts pain by 58%

The Food and Drug Administration (FDA) on Aug. 6 approved VORANIGO, the first targeted therapy for Grade 2 Isocitrate dehydrogenase (IDH) mutant glioma, a type of brain tumor. Available to patients as a once-daily pill, VORANIGO is the first significant treatment breakthrough in nearly 25 years for Grade 2 IDH mutant glioma, the drug’s maker Servier explained.

FDA approves Servier’s VORANIGO for certain brain tumors

People may be at more risk of both AIDS and hepatitis B due to similar risk factors. Having HIV and hepatitis B may lead to serious complications. However, both are treatable and preventable. Stage 3 HIV is also known as AIDS. Stage 3 HIV is the most advanced stage of...

Stage 3 HIV (AIDS) and hepatitis B: What is the connection?

Denver, CO

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

Ever wondered what your A1C numbers really mean? Trust me, you’re not alone. Many people, whether they have diabetes or are managing someone else’s, ask this question. Let’s break down the A1C to blood glucose conversion in a way that’s easy to understand and use. Key...

A1C to Blood Glucose Conversion Guide

Las Vegas, NV

Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

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Cooking With Maryann

This recipe is sooo tasty! It truly is for garlic lovers! It involves sautéing onions and mushrooms in butter and oil until golden, then adding wine to reduce. Garlic, thyme, and parsley are stirred in for flavor, followed by seasoning with salt and pepper. The dish is garnished with additional parsley and served warm, making for a savory, aromatic side. Here's what you'll need to make it:

Garlic Mushrooms in Brown Butter Herb Sauce

Clinical trials for treatments to prevent recurring strokes typically only include participants who have little to no disability from a prior stroke. A new Yale study finds that leaving patients with such disability out of trials may limit what can be concluded from their results. Patients with stroke-induced disability —...

Study: Stroke prevention trials should include patients with disabilities

Kentucky State

Northern Kentucky Tribune

Major changes to how real estate transactions are conducted are set to take affect this month that will effect how both sellers, and buyers, compensate their agents. On March 15, the National Association of Realtors (NAR) settled a lawsuit brought by home sellers regarding how broker commissions were handled. As a result of that settlement, the NAR will remove agent compensation amounts from Multiple Listing Services, provide detailed compensation information to buyers and sellers and attain a written agreement outlining that compensation structure.

Broker commissions on real estate transactions will look a lot different starting August 17

Researchers have uncovered that T-lineage acute lymphoblastic leukemia (ALL) may be frequently driven by genetic changes in noncoding portions of the DNA, according to a recent study published by Pölönen et al in Nature. The investigators believe these findings may lead to a paradigm shift in understanding of the disease.

Novel Insights May Transform Diagnosis and Treatment of Pediatric Patients With T-Lineage ALL

South Carolina State

Colleton County, SC

Explore Beaufort SC

Some beachgoers were in for a surprise this week when a bizarre looking prehistoric fish washed ashore in Colleton County along Edisto Beach at Edisto Beach State Park. It turned out to be an atlantic sturgeon.

Rare Atlantic sturgeon washes ashore on South Carolina beach

In an interview, Marc Braunstein, MD, PhD, reviewed key updates in multiple myeloma for chimeric antigen receptor (CAR) T-cell and bispecific antibody therapy, and discussed planning for transition of care. Marc Braunstein, MD, PhD. Associate Professor, Department of Medicine. Fellowship Program Director, Hematology/Oncology. Codirector, Hematology-Oncology System. NYU Grossman Long Island...

Expert Insights on Important Updates in Multiple Myeloma With Marc Braunstein, MD, PhD

NewsBreak

Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

Video content above is prompted by the following question(s):. When making treatment decisions for lower-risk...

Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

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