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Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and previously presented at the 2024 ASCO Gastrointestinal Cancers Symposium (Abstract 603). Background.

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

Servier has expanded its IDH drug armamentarium with the FDA approval for an IDH1/2 dual inhibitor. The approval represents the first major treatment advance in low-grade brain cancer in more than two decades. The new FDA approval is for Servier’s Voranigo, or vorasidenib, for adult and children ages 12 and...

Servier snags FDA approval for Voranigo, the first targeted therapy for a common type of brain tumor

Metastatic breast cancer describes a severe malignancy in which breast cancer spreads to distant parts of the body. Invasive ductal carcinoma, which accounts for the majority of breast cancer cases, can metastasize to the bones, liver, lungs, and brain. Five-year survival for metastatic breast cancer remains around 30%, signifying a significant unmet need for new and effective treatments.

Antibody Drug Conjugate Could Help in the Treatment of Brain Metastasis

A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models – all without showing signs of toxicity. Medulloblastoma is the most common malignant brain tumor in children. Survival rates vary according to which one of the four subtypes...

Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma

A new study of more than 10,000 non-smoking adults found that solid lung nodules were present in a considerable portion of study participants. Non-smokers are traditionally thought to be at low risk for lung nodules and lung cancer. The results of the study were published today in Radiology, a journal of the Radiological Society of North America (RSNA).

Solid Lung Nodules Found in 42% of Non-Smokers

Healthline

R-ICE is a treatment for non-Hodgkin's and Hodgkin's lymphoma. It combines four chemotherapy drugs that kill cancer cells and is often used prior to a stem cell transplant. Learn more.

What Is the R-ICE Chemotherapy Protocol?

For people who are at high risk of developing pancreatic cancer, regular imaging tests to monitor the pancreas may help detect the disease at an earlier stage than when pancreatic cancer is typically diagnosed in the general population, according to a new study. The study also suggests that detecting pancreatic...

Surveillance for People at High Risk of Pancreatic Cancer

Thyroid cancer stages range from 1 to 4 (sometimes referred to in Roman numerals as I, II, III, and IV). Stage 4 thyroid cancer is the most serious; stage 1 is the least severe. The stage of someone's cancer is determined by the size and spread of cancer cells from a tumor's primary site, in this case, the thyroid gland.

What Are the Stages of Thyroid Cancer?

In the last 6 months prior to PDAC diagnosis, visceral and subcutaneous adipose tissue decreased by 12.9% and 14.7%, respectively. LDL, total cholesterol and triglycerides also decreased before diagnosis. In the 36 months prior to diagnosis of pancreatic ductal adenocarcinoma, researchers observed “predominant changes” in patients’ body composition and biochemical...

Body fat, metabolic changes before pancreatic cancer diagnosis may aid in early detection

Acute kidney injury (AKI) is one of the most frequent complications of cardiac surgery and the cause is complex. Renal hypoperfusion from decreased glomerular filtration rate after cardiopulmonary bypass is a major contributor. 1 This in combination with exogenous toxins, endogenous metabolites, oxidative stress, bleeding and reperfusion injury can all...

The PROTECTION Trial – A Randomized Trial of Intravenous Amino Acids for Kidney Protection

A complete blood count, chemistry profile, immunoglobulin test, and light chain assay are among the important blood tests doctors use to help diagnose multiple myeloma. Multiple myeloma is a type of cancer that affects the white blood cells that your bone marrow produces. Doctors can help diagnose multiple myeloma using...

How Do Blood Tests Help in Multiple Myeloma Diagnosis?

In 1972, Janet Rowley sat at her dining room table and cut tiny chromosomes from photographs she had taken in her laboratory. One by one, she snipped out the small figures her children teasingly called paper dolls. She then carefully laid them out in 23 matching pairs—and warned her kids not to sneeze.

Path to precision: Targeted cancer drugs go from table to trials to bedside

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It’s crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties.

Light Can Control White Blood Cells’ Appetite for Cancer Cells

Surgery isn’t a typical treatment for multiple myeloma. But in some cases, surgery may be necessary to address complications from the disease. Multiple myeloma is a rare type of cancer that causes abnormal cells to develop in your bone marrow. As multiple myeloma spreads, it can lead to bone damage or loss.

The Role of Surgery in Treating Multiple Myeloma

Although colorectal cancer may not be entirely preventable, a person can take certain steps to reduce their risk of developing it. These include screenings, avoiding cigarettes and alcohol, and more. Colorectal cancer is a form of cancer that begins in a person’s colon or rectum. The colon is also...

Is it possible to prevent colorectal cancer?

Earlier this year, IDP-023 received fast track designation by the FDA for the treatment of patients with multiple myeloma and non-Hodgkin lymphoma. According to a new announcement, the FDA has cleared the investigational new drug (IND) application for Indapta Therapeutics’ g-natural killer (g-NK) cell therapy IDP-023 to be assessed in a phase 1 clinical trial for the treatment of patients living with progressive multiple sclerosis (MS).1.

FDA Clears Indapta Therapeutics’ IND for Cell Therapy IDP-023 in Progressive Multiple Sclerosis

In part 1 of our interview with Anna Sureda, MD, PhD, president of the European Group for Blood and Marrow Transplantation, she summarized the current treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) and follicular lymphoma (FL). For our recent coverage of the European Hematology Association 2024 Congress,...

Advancements in R/R Lymphoma: Bispecific Antibodies in Focus

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PPIs Linked to Fatigue Due to Vitamin B12 Deficiency. August 12, 2024 - Many Americans taking Proton Pump Inhibitors (PPIs) to manage acid reflux may be unaware of a significant side effect: chronic fatigue. Recent findings have highlighted the connection between PPI use and vitamin B12 deficiency, which can lead to persistent tiredness and other health issues.

Are Proton Pump Inhibitors Making Your Tired?

Matthew Galsky, MD, discusses the disease-free survival of nivolumab vs placebo in patients with high-risk muscle-invasive bladder cancer. Matthew Galsky, MD, professor of medicine (hematology and medical oncology), director of genitourinary medical oncology, codirector of the Center of Excellence for Bladder Cancer, and associate director for Translational Research at The Tisch Cancer Institute at Mount Sinai in New York, discusses the efficacy of adjuvant nivolumab (Opdivo) in the phase 3 CheckMate 274 trial (NCT02632409).

Nivolumab Shows Improved DFS in ITT and PD-L1–High Bladder Cancer

NewsNinja

One Walmart shopper is issuing a warning against buying meat at the massive retail chain—but the reason why isn’t strictly tied to Walmart. It seems that customers at stores such as Walmart believe it's acceptable to grab perishable items, such as meat or dairy, and then place them on any available shelf if they decide they no longer want them.

Walmart customer shares why they will never shop for meat at the store leaving viewers torn

NewsBreak

FDA Accepted PD-L1 Inhibitor Durvalumab for the Treatment of Endometrial Cancer

On June 14, 2024, the U.S. FDA approved AstraZeneca's Durvalumab (IMFINZI®) for primary advanced or recurrent endometrial cancer with mismatch repair deficiency. Endometrial cancer is the...

FDA Accepted PD-L1 Inhibitor Durvalumab for the Treatment of Endometrial Cancer

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