Isaac Guerendo had a 76-yard run to clinch the win for the 49ers in Thursday Night Football

Former Louisville football player and San Francisco 49ers rookie running back Isaac Guerendo busted out a 76-yard carry yesterday during Thursday Night Football to clinch the victory for the 49ers over the Seattle Seahawks .

The 49ers picked Guerendo in the fourth round of the 2024 NFL Draft . He has been getting playing time mainly on special teams as a kick return and has had limited carries through six games.

49ers All-Pro running back Christian McCaffrey is injured and has yet to play a snap this year, so Jordan Mason has been the lead back to start the season, and he's done a pretty good job as he is leading the NFL in rushing yards (609) to start the season.

He was primed for another big night until he suffered a shoulder injury in the first half. Guerendo took the bulk of the carries in the second half.

After a Seahawks touchdown to cut the 49ers lead to five points, San Franciso had the ball on its 19-yard line with under two minutes remaining in the game.

On first and 10, Guerendo busted through the right side of the offensive line, running past the defenders and eventually sliding down at the Seahawks' five-yard line, forcing them to burn one timeout.

Watch Isaac Guerendo's 76-yard run in Thursday Night Football

Who won in 49ers vs Seahawks?

The 49ers scored a touchdown to cap off that drive and defeated the Seahawks, 36-24.

Guerendo finished the game with a career-high 10 carries and 99 rushing yards.

Reach sports reporter Prince James Story at pstory@gannett.com and follow him on X at @PrinceJStory.

This article originally appeared on Louisville Courier Journal: Isaac Guerendo had a 76-yard run to clinch the win for the 49ers in Thursday Night Football