Clinical Trial: Chronic CBD Use “Reduced Excessive Daytime Sleepiness”

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According to the results of a new study , “Chronic CBD administration reduced excessive daytime sleepiness”.

Titled Chronic Cannabidiol Administration Mitigates Excessive Daytime Sleepiness and Fatigue in Patients with Primary Hypertension: Insights from a Randomized Crossover Trial, the study was published in the peer reviewed journal Cannabis and Cannabinoid Research: It was published online ahead of print by the National Institute of Health . The study was conducted by researchers at University Hospital of Split in Croatia.

“The chronic effects of cannabidiol (CBD) supplementation on factors that could impact the quality of life (anxiety, sleeping quality, memory, etc.) are poorly explored”, states the study. “Hence, the aim of this study was to establish whether chronic CBD supplementation will improve self-reported outcomes related to quality of life.”

In this randomized crossover trial, 64 patients with primary hypertension were assigned to receive CBD (225-450 mg) for 5 weeks followed by 5 weeks of placebo or vice versa, with a 2-week washout in-between the two. Self-reported outcomes were assessed using short form-36 (SF-36), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), memory complaint questionnaire (MAC-Q), and state-trait anxiety inventory (STAI).

“Five-week administration of CBD, but not of placebo, resulted in improvement of ESS score (F = 6.738, p = 0.011), as well as fatigue/vitality (Δ _CBD = 5.0, p < 0.001) and psychological well-being dimensions of SF-36 (Δ _CBD = 7.4, p = 0.039)”, found the study’s researchers.

The study concludes by stating:

Chronic CBD administration reduced excessive daytime sleepiness, despite the fact that no change was observed in self-reported quality of sleep. Furthermore, self-reported fatigue and psychological well-being dimensions of quality of life also improved following chronic CBD use.

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