SMU Mustangs at #22 Louisville Cardinals Prediction and Odds | College Football Week 6

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The 22nd-ranked Louisville Cardinals (3-1, 1-0 ACC) host the SMU Mustangs (4-1, 1-0) this Saturday afternoon in an ACC matchup. Louisville is coming off a 31-24 road loss to the Notre Dame Fighting Irish in Week 5. Quarterback Tyler Shough completed 24-of-41 passes for 264 yards and had three touchdowns and one interception. Running back Isaac Brown carried the ball 13 times for 72 yards.

The Mustangs are coming off a 42-16 home win over the Florida State Seminoles in Week 5. Running back Brashard Smith carried the ball 17 times for 129 yards and had one touchdown. Quarterback Kevin Jennings completed 16-of-23 passes for 254 yards and three touchdowns.

Will the Mustangs continue their excellent season, or will the Cardinals rebound from a crucial loss to Notre Dame?

SMU Mustangs vs. Louisville Cardinals Odds

Team Spread Total Money Line

SMU Mustangs +7 Over 57 +195

-112 -112

Louisville Cardinals -7 Under 57 -238

-108 -108

**Odds Subject to Change**

SMU Mustangs vs. Louisville Cardinals Match Details

• Fixture: SMU Mustangs vs. Louisville Cardinals
• Date and Time: Saturday, October 5th, 2024 at Noon ET
• Location: L&N Federal Credit Union Stadium, Louisville, Kentucky

Key Stats

SMU Mustangs

The SMU Mustangs enter 4-1, averaging 42.20 points per game this season. Running back Brashard Smith leads the team in rushing, averaging 101.80 yards per game, and has seven touchdowns. Quarterback Kevin Jennings averages 146.60 passing yards per game and has completed 63.40% of his passes. So far this season, he has thrown six touchdowns and one interception.

Tight End RJ Maryland is averaging 44.20 receiving yards per game and has scored three touchdowns. Jake Bailey is averaging 34.0 receiving yards per game. Defensively, SMU has nine interceptions and seven sacks. They are allowing 21.20 points per game.

Louisville Cardinals

The Cardinals enter the game 3-1, averaging 41.50 points per game this season. Isaac Brown leads the team in rushing, averaging 61.25 yards per game with one touchdown. Quarterback Tyler Shough is averaging 278.50 passing yards per game and is completing 65.0% of his passes. To start the year, he has thrown 11 touchdowns and one interception.

Wide receiver Ja’Corey Brooks averages 92.0 receiving yards per game, while Chris Bell averages 42.0 receiving yards per game. From a defensive standpoint, Louisville has two interceptions and 10 sacks. They are allowing 16.00 points per game.

Prediction

Louisville is a touchdown favorite in this game, but that looks to be too many points to give. SMU has been a pleasant surprise this season in the ACC, having shown that they can score points quickly. Their only loss was to an undefeated BYU team in Week 3, a loss by three points.

Louisville on the other hand, has also played well this season, but their offense has not been as consistent. The Cardinals also have been vulnerable on defense at times, something the Mustangs should be able to take advantage of. This is a game that Louisville should win with a bounce-back effort, however, backing the Mustangs to keep this game inside a touchdown will be our best bet because of the balance they have shown offensively and because of their ability to score points quickly.

Final Pick

SMU Mustangs +7 (-112)

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Article originally written by Matthew Lowrimore.