To determine the rate of clinically significant red blood cell (RBC) antibody seroconversion in pregnancy and associated risk factors and neonatal outcomes. This is a retrospective cohort study of all deliveries within a large multi-hospital system from July 2016 to March 2023. Deliveries with a missing RBC antibody screen on admission for delivery were excluded, as were deliveries with a positive antibody screen on admission for delivery without a record of antecedent type and screen (T&S) in that pregnancy. Deliveries were categorized as 1) not possessing clinically significant antibodies (which includes those with a negative antibody screen, evidence of passive immunity solely due to Rh(D) immune globulin (RhIG), or possessing only non-clinically significant RBC antibodies); 2) previously alloimmunized (i.e. pregnancies that demonstrated clinically significant antibodies on the first T&S, regardless if they accrued additional antibodies throughout the pregnancy); or 3) seroconverted (i.e. no clinically significant antibodies on the first T&S with subsequent development of alloimmunization with clinically significant antibodies). For neonates born to seroconverted patients with clinically significant antibodies, neonatal outcomes such as initial hemoglobin, need for transfusion, and neonatal intensive care unit (NICU) admission were ascertained chart abstraction. All records were linked with an existing validated database, inclusive of maternal characteristics and pregnancy outcomes, and comparisons were made between three categories based on antibody status with a sub-analysis of two categories. Bivariate analysis was performed with Chi-square for categorical and Wilcoxon rank-sum or Kruskal-Wallis test for continuous variables.

Nurse Amino Ali discovered she had the rare Ro subtype, most common in people of black heritage.

IU sophomore Caroline Price, a blood cancer survivor, volunteers on campus for an organization called Gift of Life. “I had a rare blood disease,” Price said. “The best, and really the only way they were going to be able to treat me, and heal me completely, was through a bone marrow transplant.”

Learn why doctors use immunophenotyping, how it works, and how it helps in diagnosis and treatment.

BRISTOL, United Kingdom — Researchers have finally cracked a half-century-old mystery in the world of blood science. A team of scientists from NHS Blood and Transplant and the University of Bristol has discovered a new blood group called MAL, shedding light on a puzzling antigen that has baffled experts since the 1970s.

Congenital Dyserythropoietic Anemia (CDA) is a rare blood disorder affecting red blood cell production. This condition leads to anemia, causing fatigue, weakness, and pale skin. CDA is inherited, meaning it's passed down through families. There are three main types: CDA I, CDA II, and CDA III, each with unique characteristics and severity. Symptoms can vary widely, from mild to severe, and may include jaundice, enlarged spleen, and gallstones. Diagnosis often involves blood tests, bone marrow examination, and genetic testing. Treatment options depend on the type and severity but may include blood transfusions, medications, or even bone marrow transplants. Understanding CDA is crucial for managing symptoms and improving quality of life.

Blood typing is essential for determining if a patient can safely receive donated blood. However, accurately matching donor blood with recipients is complex, and errors can result in severe, life-threatening reactions. Advances in molecular biology have revolutionized blood classification, offering far greater precision and reliability than conventional testing. This whitepaper...

Pronto disponible en español Send us your comments (link sends e-mail) Blood vessels wind all throughout your body. They ensure that blood, and the oxygen it carries, reaches all your body’s cells and tissues. Arteries carry oxygen-rich blood from your heart to organs and tissues. Veins carry blood back to your heart to pick up more oxygen. And tiny vessels called capillaries connect the arteries to the veins.

Did you know that your blood type can reveal hidden insights about your health and even your personality? Blood, a precious and ubiquitous crimson liquid, flows through your body, carrying vital information about your ancestry and well-being. Yet, many of us take it for granted.

What is Vasopressin-Resistant Diabetes Insipidus? Imagine feeling thirsty all the time, no matter how much water you drink. That's what life can be like for someone with Vasopressin-Resistant Diabetes Insipidus. This condition is a rare disorder where the kidneys can't respond to vasopressin, a hormone that helps control water balance in the body. As a result, people with this condition produce large amounts of urine and feel constantly thirsty. Unlike diabetes mellitus, which involves blood sugar, this type of diabetes is all about water regulation. It's often caused by genetic mutations affecting the kidneys' ability to respond to vasopressin. Treatment usually involves medications that help the kidneys retain water and lifestyle changes to manage symptoms. Understanding this condition can help those affected lead healthier lives and raise awareness about this uncommon disorder.