Tampa Bay Buccaneers at New Orleans Saints: Predictions, picks and odds for NFL Week 6 game

It's anyone's guess as to who is going to claim the NFC South, but two teams will try to get a leg-up on each other in Week 6 with the Tampa Bay Buccaneers (3-2) facing the New Orleans Saints (2-3).

A Thursday night thriller didn't fall in Tampa Bay's favor when the Atlanta Falcons came from behind to stun the Buccaneers behind Kirk Cousins ' sensational performance. The Buccaneers could've given themselves a sizable lead in the division, but now they have to try and hold serve on the road.

The fantastic start in New Orleans has quickly dissolved into a three-game losing skid. Not only has the magic worn off, but there's now questions at quarterback after Derek Carr was injured against the Kansas City Chiefs . He won't be playing , so the Saints need to regroup fast to avoid another loss.

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Saints vs. Buccaneers odds, moneyline, over/under

The Buccaneers are favorites to defeat the Saints, according to the BetMGM NFL odds . Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code .

• Spread: Buccaneers (-2.5)
• Moneyline: Buccaneers (-145); Saints (+120)
• Over/under: 42

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NFL Week 6 odds, predictions and picks

Seahawks vs. 49ers | Bears vs. Jaguars | Ravens vs. Commanders | Packers vs. Cardinals | Patriots vs. Texans | Saints vs. Buccaneers | Eagles vs. Browns | Titans vs. Colts | Broncos vs. Chargers | Raiders vs. Steelers | Panthers vs. Falcons | Cowboys vs. Lions | Giants vs. Bengals | Jets vs. Bills

Lorenzo Reyes: Buccaneers 21, Saints 16

This is a tricky game to pick; both squads are division rivals familiar with each other, they’re both mercurial. But New Orleans has dropped three games in a row and Derek Carr is expected to miss multiple games.

Tyler Dragon: Buccaneers 27, Saints 24

In advance of Hurricane Milton, the Bucs decided to leave for New Orleans on Tuesday. The Tampa Bay area has already seen damage from Hurricane Helene. Maybe the Bucs will use the forces of Mother Nature as a rallying cry. The Saints have lost three straight games after beginning the season 2-0.

Jordan Mendoza: Buccaneers 24, Saints 20

Derek Carr missing this week spells big trouble for a New Orleans team that needs to be jumped. Tampa Bay gets the bad taste out of its mouth win a win.

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This article originally appeared on USA TODAY: Tampa Bay Buccaneers at New Orleans Saints: Predictions, picks and odds for NFL Week 6 game