First look: Kansas City Chiefs at San Francisco 49ers odds and lines

The Kansas City Chiefs (5-0) meet the San Francisco 49ers (3-3) at Levi's Stadium Sunday afternoon. Kickoff is set for 4:25 p.m. ET (FOX). Below, we look at Chiefs vs. 49ers odds from BetMGM Sportsbook's NFL odds before making our expert NFL picks and predictions later in the week.

The Chiefs are coming off their bye week and have not tasted defeat in 11 straight games. Their last loss came in Week 16 of last season. That's saying something considering RB Isiah Pacheco (leg) and WR Rashee Rice (knee) are on IR. RB Kareem Hunt rushed 27 times for 102 yards and a TD in Week 5, and TE Travis Kelce had a 9-70-0 line through the air.

The Niners enter this Super Bowl LVIII rematch fresh off a 36-24 victory over the Seattle Seahawks. RB Jordan Mason went down with a sprained AC joint in his shoulder, and RB Isaac Guerendo picked up the slack with 10 rushes for 99 yards. QB Brock Purdy had a standout game with 255 passing yards and 3 scores.

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Chiefs at 49ers odds

Provided by BetMGM Sportsbook ; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds . Lines last updated Monday at noon ET.

• Moneyline (ML): Chiefs +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
• Against the spread (ATS): Chiefs +1.5 (-110) | 49ers -1.5 (-110)
• Over/Under (O/U): 46.5 (O: -110 | U: -110)

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2024 betting stats

• ML : Chiefs 5-0 | 49ers 3-3
• ATS : Chiefs 4-1 | 49ers 3-3
• O/U : Chiefs 2-3 | 49ers 4-2

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Chiefs vs. 49ers head-to-head

The Chiefs lead the all-time series 9-7 in the regular season. They have met twice in the Super Bowl over the last 4 years with K.C. winning both Lombardi Trophies. They last faced off in the regular season in 2022 with the Chiefs stealing the Niners' gold in a 44-23 shellacking. QB Patrick Mahomes threw for 423 yards, 3 TDs and 1 INT.

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This article originally appeared on USA Today Sportsbookwire: First look: Kansas City Chiefs at San Francisco 49ers odds and lines