Cleveland Guardians at Milwaukee Brewers odds, picks and predictions

The Cleveland Guardians (72-50) and Milwaukee Brewers (70-52) play the middle contest of a 3-game interleague series Saturday. First pitch from American Family Field is set for 7:15 p.m. ET (FOX). Let’s analyze FanDuel Sportsbook’s lines around the Guardians vs. Brewers odds and make our expert MLB picks and predictions for the best bets.

Season series: Brewers lead 1-0

The Brewers scored 3 runs in the bottom of the 1st inning in Friday’s series opener, backing former Guardians RHP Aaron Civale in a win against his former team. Milwaukee ended up leading wire-to-wire, building a 5-0 lead after 4 innings before Cleveland struck for 3 runs in the top of the 8th to make it interesting.

The late scoring by the Guardians against the bullpen for the Brewers killed Under (7.5) bettors, as the Over just came in.

The Guardians saw their 5-game win streak go up in smoke. The Under is still 5-3-1 in the past 9 outings despite the Over result on Friday.

The Brewers have split the past 14 games at home, going 7-7, while the Over has cashed at a 7-3-1 clip in the past 11 outings, while going 10-4-2 in the past 16 games at home.

With its win Friday, Milwaukee improved to 27-14 against the American League, by far the most interleague wins of any team in the majors. In fact, the 2nd-best mark is 22 wins by the Atlanta Braves, Chicago Cubs and Tampa Bay Rays.

Guardians at Brewers projected starters

RHP Tanner Bibee vs. RHP Freddy Peralta

Bibee (10-4, 3.39 ERA) makes his 24th start. He has a 1.09 WHIP, 2.2 BB/9 and 9.7 K/9 in 127 1/3 IP.

• Last start: Win, 5 2/3 IP, 1 ER, 6 H, 0 BB, 5 K in 5-3 road victory vs. Minnesota Twins last Sunday
• 2024 road splits: 6-2, 2.88 ERA (68 2/3 IP, 22 ER), 1.06 WHIP, .227 opponents’ batting average (OBA), 15 BB, 71 K in 12 starts
• Career vs. Brewers: Win, 6 IP, 2 R (1 ER), 3 H, 4 BB, 7 K in 4-2 win at Progressive Field June 24, 2023 in only start vs. MIL

Peralta (7-7, 4.11 ERA) makes his 25th start. He has a 1.22 WHIP, 3.4 BB/9 and 10.9 K/9 in 131 1/3 IP.

• Last start: Loss, 6 IP, 4 ER, 5 H (2 HR), 2 BB, 4 K in 5-2 home setback vs. Los Angeles Dodgers Monday
• 2024 home splits: 3-4, 4.54 ERA (67 1/3 IP, 34 ER), 1.17 WHIP, .236 OBA, 13 HR, 19 BB, 81 K in 12 starts
• Career vs. Guardians: 0-1, 4.05 ERA (6 2/3 IP, 3 ER), 1.50 WHIP, 12.2 K/9 in 1 start (2 appearances)

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Guardians at Brewers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:50 a.m. ET.

• Moneyline (ML): Guardians +110 (bet $100 to win $110) | Brewers -130 (bet $130 to win $100)
• Run line (RL)/Against the spread (ATS): Guardians +1.5 (-210) | Brewers -1.5 (-130)
• Over/Under (O/U): 7.5 (O: -105 | U: -115)

Guardians at Brewers picks and predictions

Prediction

Guardians 6, Brewers 3

The GUARDIANS (+110) are a nice play for the bounce-back game Saturday behind Bibee.

The Cleveland right-hander has picked up 10 victories this season, and he has even more impressive splits on the road.

On the flip side, the Brewers (-130) are a risky play behind Peralta, who has been a bit on the erratic side, while posting a losing record and a 4.54 ERA at home this season.

If you’re a bit more adventurous, and the moneyline isn’t good enough for you, take the GUARDIANS -1.5 (+176) for the chance to cash in.

There is risk here, as Cleveland has 5 wins in the past 6 outings, but 3 of those wins are by a single run. However, the Guardians have won Bibee’s past 4 starts, and 3 of those victories have come by multiple runs.

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OVER 7.5 (-105) is once again the play Saturday.

We had a close shave Friday night, as Under bettors were on the right side until a 3-run outburst by Cleveland in the top of the 8th inning flipped things to an Over.

The Over is 9-5-1 in the past 15 games for the Guardians, while going 3-0-1 in the past 4 games for the Brewers.

You may love betting on sports, but until college football and the NFL seasons officially start, the pickings can get slim. You can fill some of that time and scratch that itch at online casinos and enjoy slots, blackjack, video poker and more.

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