Chicago White Sox at Houston Astros odds, picks and predictions

The Houston Astros (66-56) welcome the Chicago White Sox (30-94) to Minute Maid Park Sunday for the finale of their 3-game series. First pitch is set for 2:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the White Sox vs. Astros odds and make our expert MLB picks and predictions for the best bets.

Season series: Astros lead 3-2

The White Sox beat the Astros 5-4 to open the series Friday, but lost 6-1 Saturday, closing as a +225 or longer underdog in each.

They are just 2-6 over their last 8 games and are 12-50 on the road. Chicago has scored 2 runs or fewer in 3 of its last 4 games. It is 53-71 against the spread (ATS).

The Astros, who lead the AL West, have been on a tear, winning 9 of their last 10 games. They have won 3 of their last 4, but are just 1-3 ATS in those games. Houston has allowed 2 runs or fewer in 5 of its last 6 games. It is 33-27 at home and 63-59 ATS.

White Sox at Astros projected starters

LHP Ky Bush vs. LHP Framber Valdez

Bush (0-1, 5.19 ERA) makes his 3rd career start. He has a 2.31 WHIP, 12.5 BB/9 and 5.2 K/9 in 8 2/3 IP.

• Last start: Win, 4 2/3 IP, 2 ER, 6 H, 7 BB, 2 K in 12-2 home win over the New York Yankees Monday
• 2024 away stats: 0-1, 6.75 ERA (4 IP, 3 ER), 1.75 WHIP, 6.8 K/9 in 1 start
• Rookie’s 1st time facing the Astros

Valdez (12-5, 3.38 ERA) makes his 22nd start. He has a 1.17 WHIP, 2.9 BB/9 and 8.4 K/9 in 130 2/3 IP.

• Last start: Win, 5 2/3 IP, 1 ER, 3 H, 1 BB, 9 K in 6-1 road win over the Tampa Bay Rays Monday
• 2024 home stats: 6-2, 3.29 ERA (63 IP, 23 ER), 1.16 WHIP, 9.3 K/9 in 10 starts
• Career vs. White Sox: 3-2, 2.93 ERA (30 IP, 13 ER), 1.27 WHIP, 7.4 K/9 in 7 appearances (6 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Astros odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:51 a.m. ET.

• Moneyline (ML): White Sox +320 (bet $100 to win $320) | Astros -405 (bet $405 to win $100)
• Run line (RL)/Against the spread (ATS): White Sox +1.5 (+146) | Astros -1.5 (-178)
• Over/Under (O/U): 8.5 (O: +100 | U: -122)

White Sox at Astros picks and predictions

Prediction

Astros 6, White Sox 2

PASS.

The Astros are far too expensive to take here, and facing a strong starting option, the White Sox have little value as a sizable moneyline underdog.

BET ASTROS ALTERNATE RUN LINE -2.5 (-106).

The Astros are the 7th-best ATS team as a favorite at 41-48. In their last 10 games they have won 9 with 6 of those wins by 2 or more runs. They have covered a 2-run spread in Valdez’s last 2 starts as well, beating opponents a combined 10-3.

The White Sox are among the worst teams in the MLB and have struggled heavily on the offensive end. They have scored 9 runs total in their last 4 games. Considering those trends, expect a sizable Astros win and take ASTROS -2.5 (-106).

BET UNDER 8.5 (-122).

The White Sox are 4-6 O/U in their last 10 games and are 56-62-6 O/U this season. They have scored 2 runs or fewer in 6 of their last 10 games, and in 3 of their last 4.

Houston has allowed 2 runs or fewer in 5 of its last 6 and has scored fewer than 4 runs in 3 of its last 4 games. It has gone Under in 4 of its last 5 games and is 48-70-4 O/U. Couple it all and back UNDER 8.5 (-122).

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips

SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Fantasy baseball help from BaseballHQ.com:

Subscribe now to dominate the competition.