Chicago White Sox at San Francisco Giants odds, picks and predictions

The Chicago White Sox (30-95) and San Francisco Giants (63-63) open a 3-game series in San Francisco on Monday. First pitch for the opener is at 9:45 p.m. ET from Oracle Park. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting, Giants won 2-1 in 2023

The White Sox are coming off a 2-0 shutout loss to the Houston Astros on Sunday, losing 2 out of 3 games. They have lost 2 in a row and only have 3 wins in their last 31 games.

The Giants are coming off a 4-2 road win over the Oakland A’s on Sunday in 10 innings, splitting the 2-game series. They are 2-5 in their last 7 games.

White Sox at Giants projected starters

RHP Jonathan Cannon vs. LHP Kyle Harrison

Cannon (2-6, 4.02 ERA) makes his 14th start and 16th appearance. He has a 1.30 WHIP, 2.6 BB/9 and 6.1 K/9 in 80 2/3 IP.

• Last start: Loss, 4 2/3 IP, 3 ER, 5 H, 3 BB, 4 K in 4-1 home loss to New York Yankees on Tuesday
• Sox have lost 6 of his last 7 starts
• Facing Giants for 1st time

Harrison (6-5, 4.14 ERA) makes his 22nd start. He has a 1.31 WHIP, 2.9 BB/9 and 8.4 K/9 in 111 IP.

• Last start: No decision, 5 IP, 3 ER, 6 H, 2 BB, 6 K in 5-4 home loss to Atlanta Braves on Tuesday
• Has 7.43 ERA in 3 August starts
• Facing White Sox for 1st time

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:07 a.m. ET.

• Moneyline (ML): White Sox +200 (bet $100 to win $200) | Giants -250 (bet $250 to win $100)
• Run line (RL)/Against the spread (ATS): White Sox +1.5 (-105) | Giants -1.5 (-115)
• Over/Under (O/U): 8 (O: -105 | U: -115)

White Sox at Giants picks and predictions

Prediction

Giants 5, White Sox 2

At this point, why would anyone bet the White Sox to win? They lost 21 straight games and are 3-28 in their last 31 games. They have baseball’s worst road record at 12-51. They have lost 6 of Cannon’s last 7 starts.

The Giants are 36-27 at home.

But betting the Giants at -250 isn’t worth the action.

PASS.

Fourteen of Chicago’s last 17 losses have been by 2 or more runs. The Sox are 26-36 ATS as road dogs.

Eight of the Giants’ last 9 wins have been by multiple runs.

BET GIANTS -1.5 (-115).

The White Sox have scored 2 or fewer runs in 5 of their last 7 games while the Giants have allowed 2 or fewer runs in 3 straight games and in their last 4 wins.

BET UNDER 8 (-115).

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips

SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Fantasy baseball help from BaseballHQ.com:

Subscribe now to dominate the competition.