San Francisco Giants at Seattle Mariners odds, picks and predictions

The San Francisco Giants (65-64) and Seattle Mariners (64-64) open a 3-game interleague series Friday. First pitch from T-Mobile Park is set for 10:10 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Mariners odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Mariners won 2-1 last year

The big news out of Seattle Thursday was that Scott Servais was relieved of his managerial duties, as the Mariners blew a 10-game lead in the AL West, slipping to .500 since mid-June. The final straw was a 1-8 performance on the team’s recent road trip.

The last time the Mariners were at home they swept the New York Mets in an interleague series. They’ll look to interim manager Dan Wilson to try and snap them back on track.

The Over is 4-1-1 in the past 6 games for the Mariners, but the Under is 5-2 in the past 7 outings at home.

For the Giants, they suffered a 6-2 loss at home against the Chicago White Sox Wednesday, but San Francisco still won 2 of 3 games in the series. The Giants are 4-1 in the past 5 outings, with the Under 3-1-1 in the span.

On the road, San Francisco has won 3 in a row while going 5-1 in the past 6 outings. The Over is 5-2 in the past 7 road contests for the Giants, too.

Giants at Mariners projected starters

RHP Hayden Birdsong vs. RHP Luis Castillo

Birdsong (3-3, 5.01 ERA) makes his 10th start. He has a 1.38 WHIP, 4.8 BB/9 and 10.7 K/9 in 41 1/3 IP.

• Last start: Loss, 4 2/3 IP, 1 ER, 3 H, 3 BB, 5 K in 2-0 road setback vs. Oakland A’s Saturday
• 2024 road splits: 2-2, 5.64 ERA (22 1/3 IP, 14 ER), 1.39 WHIP, .235 opponents’ batting average (OBA), 12 BB, 28 K in 5 starts
• Has never faced Mariners

Castillo (10-12, 3.51 ERA) makes his 27th start. He has a 1.17 WHIP, 2.5 BB/9 and 9.0 K/9 in 153 2/3 IP.

• Last start: Loss, 5 1/3 IP, 4 ER, 5 H (2 HR), 3 BB, 6 K in 7-2 road setback vs. Pittsburgh Pirates Saturday
• 2024 home splits: 6-5, 2.85 ERA (85 1/3 IP, 27 ER), 1.07 WHIP, .232 OBA, 8 HR, 16 BB, 94 K in 14 starts
• Career vs. Giants: 2-1, 3.64 ERA (29 2/3 IP, 12 ER), 1.18 WHIP, 14.3 K/9 in 5 starts

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Giants at Mariners odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:30 a.m. ET.

• Moneyline (ML): Giants +128 (bet $100 to win $128) | Mariners -152 (bet $152 to win $100)
• Run line (RL)/Against the spread (ATS): Giants +1.5 (-164) | Mariners -1.5 (+136)
• Over/Under (O/U): 7.5 (O: -106 | U: -114)

Giants at Mariners picks and predictions

Prediction

Mariners 5, Giants 3

The MARINERS (-152) are a nice play as moderate favorites, as Seattle gets the bump with the managerial move.

Seattle is back home, too, and that should snap it back into form. The M’s have won 4 in a row in front of the home fans, while San Francisco has a losing record across the past 17 road contests, going 8-9.

If you’re really adventurous, and the moneyline doesn’t get it for you, take the MARINERS -1.5 (+136). Seattle has just 4 wins since Aug. 9, but each of the wins were by 4 or more runs.

The Giants +1.5 (-164) are an impressive 10-3 in the past 13 games as underdogs on the run line, but they’re facing a Mariners team which had a fire lit under it with the dismissal of its skipper.

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OVER 7.5 (-106) is the lean, but go with a small-unit play at best.

The Over is 7-3 in the past 10 meetings between these West Coast interleague foes.

And while the Giants have cashed the Under at a 3-1-1 pace in the past 5 outings, the Over has an 8-7-1 edge in the previous 16 contests. For the Mariners, the Over is 4-1-1 in the past 6 outings, too.

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