First look: Notre Dame at Purdue odds and lines

The No. 19 Notre Dame Fighting Irish (1-1) take on the Purdue Boilermakers (1-0) Saturday at Ross-Ade Stadium. Kickoff is set for 3:30 p.m. (CBS). Below, we look at Notre Dame vs. Purdue odds from BetMGM Sportsbook before making our expert college football picks and predictions later in the week.

The Fighting Irish were laid to rest by the Northern Illinois Huskies 16-14 last weekend. Notre Dame was a 28-point favorite in the setback and fell more than 10 spots in the Coaches Poll. QB Riley Leonard had a dreadful game, going 20-for-32 for 163 yards, 0 TDs and 2 INTs.

Purdue put its feet up in a 49-0 shellacking of the Indiana State Sycamores Aug. 31. QB Hudson Card was immaculate, going 24-for-25 for 273 yards and 4 TDs. The Boilers had the week off before welcoming the Irish to town.

Notre Dame is No. 19 in the US LBM Coaches Poll.

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Notre Dame at Purdue odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:15 a.m. ET.

• Moneyline (ML): Notre Dame -500 (bet $500 to win $100) | Purdue +360 (bet $100 to win $360)
• Against the spread (ATS): Notre Dame -12.5 (-110) | Purdue +12.5 (-110)
• Over/Under (O/U): 45.5 (O: -110 | U: -110)

2024 betting stats

• ML: Notre Dame 1-1 | Purdue 1-0
• ATS: Notre Dame 1-1 | Purdue 1-0
• O/U: Notre Dame 0-2 | Purdue 0-1

Notre Dame vs. Purdue head-to-head

Notre Dame has won 8 straight meetings against Purdue, dating back to 2008. Their last clash came in 2021, when the Irish won 27-13, covering as 7.5-point favorites at home.

Purdue hasn’t beaten the Irish since Sept. 29, 2007, when Irish QB Jimmy Clausen split snaps with QB Evan Sharpley.

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