First look: Detroit Lions at Arizona Cardinals odds and lines

The Detroit Lions (1-1) are on the road in Week 3 to take on the Arizona Cardinals (1-1). Kickoff from State Farm Stadium is at 4:25 p.m. ET (FOX). Below, we look at Lions vs. Cardinals odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Lions, after a 26-20 season-opening win at home over the LA Rams in overtime, lost 20-16 on Sunday to the Tampa Bay Buccaneers, despite being 7.5-point underdogs with the Under (51.5) cashing in. QB Jared Goff threw 2 picks and the team went 1-for-7 in the red zone.

The Cardinals bounced back from a season-opening 34-28 road loss to the Buffalo Bills to beat the Rams 41-10 at home as 1-point favorites. The Over (46.5) cashed in. QB Kyler Murray threw 3 TD passes and finished with a perfect 158.3 passer rating.

Play our free daily Pick’em Challenge and win! Play now!

Lions at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NFL odds. Lines last updated Monday at 2:34 p.m. ET.

• Moneyline (ML): Lions -165 (bet $165 to win $100) | Cardinals +140 (bet $100 to win $140)
• Against the spread (ATS): Lions -3 (-115) | Cardinals +3 (-105)
• Over/Under (O/U): 51.5 (O: -110 | U: -110)

WIN YOUR FANTASY FOOTBALL LEAGUE!

The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!

2024 betting stats

• ML: Lions 1-1 | Cardinals 1-1
• ATS: Lions 1-1 | Cardinals 2-0
• O/U: Lions 0-2 | Cardinals 2-0

FOOTBALL NEVER STOPS

Live games, analysis and more 7 days a week: Get ESPN+

Lions vs. Cardinals head-to-head

The Cardinals and Lions have faced each other 69 times. The Lions lead all-time 35-28-6. The last time they met, it was in 2021 and the Lions won 30-12.

Lions are 4-0-1 in their last 5 meetings, not having lost since 2015.

Murray is 0-2-1 in his career against the Lions. Goff, between playing for the Lions and the Rams, is 8-1 against Arizona with 14 TDs and 3 INTs.

For more sports betting picks and tips

SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire