Ohio State at Michigan State odds, picks and predictions

The 3rd-ranked Ohio State Buckeyes (3-0, 0-0 Big Ten) travel to meet the Michigan State Spartans (3-1, 1-0) Saturday in a conference game at Spartan Stadium. Kickoff is scheduled for 7 p.m. ET (Peacock). Let’s analyze BetMGM Sportsbook’s college football odds around the Ohio State vs. Michigan State odds, and make our expert college football picks and predictions.

The Buckeyes have rolled Akron, Western Michigan and Marshall to start the season, but that isn’t exactly a gauntlet. Ohio State has scored 49 or more points in each of the 3 wins, which have come by 35 or more points. The Over has cashed in all 3 outings for Ohio State.

The Spartans play their 2nd conference game of the season. Michigan State topped Maryland 27-24 on the road as an 8.5-point underdog as the Over (44.5) cashed. That was the only time the total has gone high in 4 games for Sparty.

Michigan State followed the win over Maryland with a 40-0 victory against Prairie View A&M, but it suffered a 23-19 loss at Boston College last week in the emotional Red Bandanna game for the Eagles. MSU did hang on for the cover as a 5-point underdog.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Ohio State at Michigan State odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at 1:15 a.m. ET.

• Moneyline (ML): Ohio State -3000 (bet $3,000 to win $100) | Michigan State +1300 (bet $100 to win $1,300)
• Against the spread: Ohio State -23.5 (-115) | Michigan State +23.5 (-105)
• Over/Under (O/U): 48.5 (O: -110 | U: -110)

Ohio State at Michigan State picks and predictions

Prediction

Ohio State 45, Michigan State 16

Ohio State (-3000) will cost you 30 times your potential return. In other words, if you risk $100, you make just $3.33 in profit. It should go without saying, but taking such heavy favorites is a foolish wager and a terrible long-term betting strategy.

AVOID.

This is a big number, but OHIO STATE -23.5 (-115) is worth a look at this price.

The Buckeyes have won the past 8 meetings in this series since Nov. 19, 2016, and each of the past 5 wins in the series have been by 24 or more points. The average winning margin is 34.6 PPG in the past 7 wins by Ohio State in this series, too.

OVER 48.5 (-110) might be the strongest play on the board in this Big Ten battle.

The Buckeyes have collected the Over in all 3 games to date, going for 49 or more points in each outing.

The Over has also cashed in each of the past 2 meetings in East Lansing, with the winning team collecting 49 or more points in 3 of the past 4 outings in the series. It’s very possible Ohio State could take on this total all on its own.

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