Iowa State at West Virginia odds, picks and predictions

The No. 13 Iowa State Cyclones (5-0, 2-0 Big 12) and West Virginia Mountaineers (3-2, 2-0) meet at Milan Puskar Stadium Saturday. Kickoff is scheduled for 8 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s college football odds around the Iowa State vs. West Virginia odds, and make our expert college football picks and predictions.

Iowa State dominated Baylor in a 43-21 win last week, scoring double digits in each of the final 3 quarters. The Cyclones covered the 12.5-point spread and surpassed the 44.5-point total. QB Rocco Becht threw for 277 yards with 2 TDs and 1 INT, while RB Jaylon Jackson rushed for 107 yards and 2 TDs on 15 carries.

West Virginia controlled the game from the opening whistle and dominated Oklahoma State, building a 31-7 halftime lead and coasting to a 38-14 victory. The Mountaineers won outright as 3-point road underdogs, with the game easily hitting the Under (64.5). QB Garrett Greene passed for 159 yards and rushed for a TD. RB Jahiem White had 158 yards and a TD on 19 carries.

– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Iowa State at West Virginia odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 12:56 a.m. ET.

• Moneyline (ML): Iowa State -150 (bet $150 to win $100) | West Virginia +125 (bet $100 to win $125)
• Against the spread (ATS): Iowa State -3 (-110) | West Virginia +3 (-110)
• Over/Under (O/U): 53.5 (O: -105 | U: -115)

Iowa State at West Virginia picks and predictions

Prediction

Iowa State 38, West Virginia 28

PASS.

Iowa State (-150) will take care of business in Morgantown on Saturday, but I’d rather wager with the better odds on the spread.

BET IOWA STATE -3 (-110).

While the Mountaineers have found their rhythm recently, and Morgantown is always a tough place to play, the Cyclones come in battle-tested with one of the best defenses in the country (10th in nation allowing 10 points per game) and a solid ground game (183.4 yards per game). This is a proven formula to win in tough road environments. Iowa State has covered the spread in 4 of 5 games this season and has won 9 of its last 10 against non-ranked teams.

West Virginia has struggled against ranked opponents, losing its last 7 games against AP-ranked teams. With Iowa State’s ability to exploit West Virginia’s weak pass defense (243.4 YPG) and their success covering spreads in road games, laying just a field goal on the Cyclones is a smart bet.

BET OVER 53.5 (-105).

Both teams have hit the Over in 3 of their last 4 games, showing a trend toward high-scoring matchups. West Virginia’s October games against AP-ranked teams have gone over the total in 7 of their last 8, and Iowa State has seen the Over in 4 of its last 5 October road games as a favorite against non-ranked teams.

With both offenses capable of putting points on the board (33.0 PPG for West Virginia; 31.2 for ISU) and recent history favoring the Over, expect this matchup to surpass 53.5 points.

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