First look: Virginia at Clemson odds and lines

The No. 9 Clemson Tigers (5-1, 4-0 ACC) welcome the Virginia Cavaliers (4-2, 2-1) to Memorial Stadium in Clemson, S.C. Kickoff is set for Saturday at noon ET (ACC Network). Below, we look at Virginia vs. Clemson odds from BetMGM Sportsbook’s college football odds before making our expert college football picks and predictions later in the week.

Clemson throttled the Wake Forest Demon Deacons 49-14 Saturday, covering as a 21-point road favorite. The Tigers have been a double-digit favorite in 5 straight games and are 4-1 against the spread (ATS) in those. Clemson has won 5 straight by 16 or more points following a season-opening prime-time 34-3 neutral-field loss to the then-No. 1, now-No. 4 Georgia Bulldogs. The Tigers were 10.5-point underdogs in that battle.

The Cavaliers lost at home to the Louisville Cardinals 24-20 Saturday, though they covered as 7-point underdogs with the Under (54) cashing. It was the 3rd consecutive cover for the Cavs. Like the Tigers, they have a win at Wake this season, claiming a 31-30 victory in their 2nd game of the season, pushing as 1-point favorites. Virginia, which is 2-0-1 ATS in ACC games, is led by a dynamic pass attack spearheaded by QB Anthony Colandrea, who has 1,490 passing yards with 9 touchdowns.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Virginia at Clemson odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Monday at 3:36 a.m. ET.

• Moneyline (ML): Off the board
• Against the spread (ATS): Virginia +21.5 (-110) | Clemson -21.5 (-110)
• Over/Under (O/U): 57.5 (O: -110 | U: -110)

FanDuel Sportsbook lists a ML of:

• Virginia +1100 (bet $100 to win $1,100)
• Clemson -2500 (bet $2,500 to win $100)

2024 betting stats

• ML: Virginia 4-2 | Clemson 5-1
• ATS: Virginia 4-1-1 | Clemson 4-2
• O/U: Virginia 2-4 | Clemson 2-4

Virginia vs. Clemson head-to-head

Clemson and Virginia have played a total of 49 times with the Tigers leading 40-8-1. The first meeting was in 1955, a 20-7 road win for the Tigers.

These teams have only met in the postseason once, but it was their second-to-last matchup. On Dec. 7, 2019, Clemson crushed Virginia 62-17 in the ACC Championship.

Clemson has won the last 5 vs. Virginia, including 41-23 at home Oct. 3, 2020, in the last meeting, However, Virginia covered as a 27.5-point underdog and 2-2 ATS in the last 4 contests

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