The Kansas City Chiefs (5-0) take on the San Francisco 49ers (3-3) Sunday afternoon. Kickoff from Levi's Stadium is set for 4:25 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Chiefs vs. 49ers odds , and make our expert NFL picks and predictions .
The defending champs have dealt with a slew of injuries, and QB Patrick Mahomes really has not been himself thus far. Yet, they sit at 5-0. Before their Week 6 bye, they dispatched the New Orleans Saints 26-13. Mahomes threw for 331 yards, 0 TDs and 1 INT. RB Kareem Hunt rushed 27 times for 102 yards and a score.
Niners coach Kyle Shanahan is 0-4 against Chiefs coach Andy Reid . That includes 2 regular-season matchups and 2 Super Bowls. You had better believe that Shanahan is aware of that. RB Jordan Mason (shoulder) left last week's game -- and killed a parlay for me -- with a sprained AC joint. He made it back to a full practice Friday and will be able to go. The Niners smoked the Seattle Seahawks 36-24 on Thursday Night Football last week.
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Chiefs at 49ers odds
Provided by BetMGM Sportsbook ; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds . Lines last updated Saturday at 10:41 p.m. ET.
- Moneyline (ML) : Chiefs +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
- Against the spread (ATS) : Chiefs +1.5 (-110) | 49ers -1.5 (-110)
- Over/Under (O/U) : 47 (O: -110 | U: -110)
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Chiefs at 49ers key injuries
Chiefs
- DE Michael Danna (pectoral) out
- RB Isiah Pacheco (leg) out
- WR Rashee Rice (knee) out
- WR JuJu Smith-Schuster (hamstring) questionable
49ers
- WR Jauan Jennings (hip) out
- RB Christian McCaffrey (Achilles) out
- WR Ricky Pearsall (chest) questionable
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Chiefs at 49ers picks and predictions
Prediction
49ers 24, Chiefs 20
The Niners haven't beaten the Chiefs since 2014, but that came at home, and I'm calling a similar finish to the 22-17 one then. Despite all of the injuries and lack of continuity, QB Brock Purdy has completed 65.4% of his passes for 1,629 yards, 9 TDs and 4 INTs. He was very good in last year's Super Bowl OT loss, and he'll get it done Sunday. You can go with the 49ers ( -120 ), but it makes more sense to ride with the spread.
If you like San Fran's side here, this is the way to go. Single-point victories are pretty unlikely, and there's more value on 49ERS -1.5 ( -110 ).
The Chiefs have a home run hitter in rookie WR Xavier Worthy , but other than that, they really rely on Hunt's ground-and-pound game. The Niners have more downfield threats, but they, too, rely on Mason's ball control. The Chiefs are 2-3 O/U thus far, and the Niners are 4-2. While there is no comparison of the circumstances, last year's Super Bowl needed OT to go Over 46.5. I look for a similar struggle.
Take the UNDER 47 ( -110 ).
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This article originally appeared on USA Today Sportsbookwire: Kansas City Chiefs at San Francisco 49ers odds, picks and predictions
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